Comparative Anthelmintic Efficacy Of Calotropis Procera Leaves And Moxidectin With Particular Reference To Biochemical Changes in Sheep
By: Qamar Niaz
| Prof. Dr. Muhammad Ashraf.
Contributor(s): Dr. Aneela | Mr. Muhammad Adil Rasheed.
Material type: 
BookPublisher: 2014Subject(s): Department of Pharmaoclogy & ToxicologyDDC classification: 1804,T Dissertation note: Background:
This project was designed to evaluate the anthelmintic efficacy of Chloroformic extract of Calotropis procera leaves against sheep nematodes. For this purpose hundred sheep positive for nematodal infection in BLPRI Kherimurat were selected after fecal examination.
Methodology:
The hundred animals were divided into 5 groups (Group A, Group B, Group C, Group D and Group E) having 20 animals in each group. Fecal eggs counts (EPG) and biochemical tests like the Alanine aminotransferase (ALT), Aspapartate aminotransferase (AST), Alkaline phosphatase (ALP), Albumin, Bilirubin, Creatinine and Urea were done on the day zero of the treatment. For further study, Group A served as an un-treated control. Group B, Group C and Group D were given the Chloroformic extract of Calotropis procera leaves at the dose rate of 3, 6 and 12mg/kg body weight by oral route respectively. Group E was given the Moxidectin at the dose rate of 0.2mg/kg body weight by subcut route. The biochemical tests on the day 3 showed no change in the normal level of the ALT, AST, ALP, Albumin, Bilirubin, Creatinine and Urea. The fecal EPG of all the groups were done on the day 7th and day 14th post treatment. The efficacy of the Group A and Group B was 0% both on day 7th and day 14th post treatment. The efficacy for the Group C was 19.40% and 42.53 % on the day 7th and day 14th post treatment respectively. The Group D showed the efficacy of 80.215% on day 7th and 91.36% on the day 14th of the treatment. The efficacy for the Group E was 85.97% and 93.29% on the day 7th and 14th respectively.
Statistics:
The data from the fecal eggs count and biochemical tests were analyzed by using the ANOVA and LSD.
Conclusion:
The Chloroformic extract of the Calotropis procera leaves have maximum anthelmintic effect at the dose rate of 12mg/kg body weight having no biochemical changes in the blood.
| Item type | Current location | Collection | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|
Thesis
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UVAS Library Thesis Section | Veterinary Science | 1804,T (Browse shelf) | Available | 1804,T |
Background:
This project was designed to evaluate the anthelmintic efficacy of Chloroformic extract of Calotropis procera leaves against sheep nematodes. For this purpose hundred sheep positive for nematodal infection in BLPRI Kherimurat were selected after fecal examination.
Methodology:
The hundred animals were divided into 5 groups (Group A, Group B, Group C, Group D and Group E) having 20 animals in each group. Fecal eggs counts (EPG) and biochemical tests like the Alanine aminotransferase (ALT), Aspapartate aminotransferase (AST), Alkaline phosphatase (ALP), Albumin, Bilirubin, Creatinine and Urea were done on the day zero of the treatment. For further study, Group A served as an un-treated control. Group B, Group C and Group D were given the Chloroformic extract of Calotropis procera leaves at the dose rate of 3, 6 and 12mg/kg body weight by oral route respectively. Group E was given the Moxidectin at the dose rate of 0.2mg/kg body weight by subcut route. The biochemical tests on the day 3 showed no change in the normal level of the ALT, AST, ALP, Albumin, Bilirubin, Creatinine and Urea. The fecal EPG of all the groups were done on the day 7th and day 14th post treatment. The efficacy of the Group A and Group B was 0% both on day 7th and day 14th post treatment. The efficacy for the Group C was 19.40% and 42.53 % on the day 7th and day 14th post treatment respectively. The Group D showed the efficacy of 80.215% on day 7th and 91.36% on the day 14th of the treatment. The efficacy for the Group E was 85.97% and 93.29% on the day 7th and 14th respectively.
Statistics:
The data from the fecal eggs count and biochemical tests were analyzed by using the ANOVA and LSD.
Conclusion:
The Chloroformic extract of the Calotropis procera leaves have maximum anthelmintic effect at the dose rate of 12mg/kg body weight having no biochemical changes in the blood.
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