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Antinematodal Efficacy Of Ivermectin (Oral) And Extracts Of Coriandrum Sativum In Sheep

By: Memrez Khushal Gigyani (2013-VA-564) | Dr. Muhammad Ovais Omer.
Contributor(s): Dr. Muhammad Mushtaq | Mr. Qamar Niaz | Dr. Nisar Ahmad.
Material type: materialTypeLabelBookPublisher: 2015Description: 65p.Subject(s): Department of Pharmacology and ToxicologyDDC classification: 2280-T Dissertation note: This project was designed to evaluate the anthelmintic efficacy of Coriandrum sativum plant extracts against sheep nematodes. Anthelmentic resistance (AR) is one of the major problems all over the world. This project was designed to evaluate the anthelmintic efficacy of Chloroformic and methanolic extracts of Coriandrum sativum against sheep nematodes. For this purpose sixty sheep positive for nematodal infection in BLPRI Kherimurat (Punjab) were selected after fecal examination. Experimental animals were divided into 6 groups (Group A, Group B, Group C, Group D, Group E and Group F) having 10 animals in each group. Group A was Un-treated control. Group B was given Ivermectin (orally), Group C and D was treated with Chloroformic extract of Coriandrum sativum at 50 and 100 mg/kg body weight respectively by oral route. Group E and F was treated with methalonic extract of Coriandrum sativum at 50 and 100 mg/kg body weight respectively by oral route. Percent efficacy of Group A on day 7, 14 and day 28 post treatment was 0%. The percent efficacy of the Group B was calculated on day 7 was 81.4 %, on day 14 was 87.17 % and on day 28 was 92.60 %. The efficacy of Group C on day 7, 14 and 28 was 0. Similarly the efficacy of Group D on day 7, day 14 and day 28 was also 0. Percent efficacy of Group E i.e 50 mg/kg body weight Methanolic extract of Coriandrum sativum was 20.81 % on day 7, 27.14 % on day 14, and 33.48 % on day 28. Percent efficacy of Group F i.e 100 mg/kg body weight Methanolic extract of Coriandrum sativum was 49.76 % on day 7, 56.27 % on day 14 and 60.69 % on day 28. CONCLUSION It is concluded that the methanolic extract of the Coriandrum sativum has good anthelmintic effect against nematodes in sheep.
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This project was designed to evaluate the anthelmintic efficacy of Coriandrum sativum plant extracts against sheep nematodes. Anthelmentic resistance (AR) is one of the major problems all over the world. This project was designed to evaluate the anthelmintic efficacy of Chloroformic and methanolic extracts of Coriandrum sativum against sheep nematodes.
For this purpose sixty sheep positive for nematodal infection in BLPRI Kherimurat (Punjab) were selected after fecal examination. Experimental animals were divided into 6 groups (Group A, Group B, Group C, Group D, Group E and Group F) having 10 animals in each group. Group A was Un-treated control. Group B was given Ivermectin (orally), Group C and D was treated with Chloroformic extract of Coriandrum sativum at 50 and 100 mg/kg body weight respectively by oral route. Group E and F was treated with methalonic extract of Coriandrum sativum at 50 and 100 mg/kg body weight respectively by oral route. Percent efficacy of Group A on day 7, 14 and day 28 post treatment was 0%. The percent efficacy of the Group B was calculated on day 7 was 81.4 %, on day 14 was 87.17 % and on day 28 was 92.60 %. The efficacy of Group C on day 7, 14 and 28 was 0. Similarly the efficacy of Group D on day 7, day 14 and day 28 was also 0. Percent efficacy of Group E i.e 50 mg/kg body weight Methanolic extract of Coriandrum sativum was 20.81 % on day 7, 27.14 % on day 14, and 33.48 % on day 28. Percent efficacy of Group F i.e 100 mg/kg body weight Methanolic extract of Coriandrum sativum was 49.76 % on day 7, 56.27 % on day 14 and 60.69 % on day 28.
CONCLUSION
It is concluded that the methanolic extract of the Coriandrum sativum has good anthelmintic effect against nematodes in sheep.

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