Normal view MARC view ISBD view

Principles of Animal Extrapolation

By: Calabrese, Edward J.
Material type: materialTypeLabelBookSeries: Publisher: USA : John Wiley & Sons Inc, 1983Edition: 1st.Description: 624 p.ISBN: 0471087629 (hardcover); 9780471087625 (hardcover).Subject(s): Toxicology--Animal models | Toxicity testing--Statistical methods | Toxicity testing | Toxicology, Experimental | ZoologyDDC classification: 615.90011 Calabrese 12445 1st 1983 Zoology Summary: Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.
List(s) this item appears in: Wildlife
Tags from this library: No tags from this library for this title. Add tag(s)
Log in to add tags.
    average rating: 0.0 (0 votes)
Item type Current location Collection Call number Status Date due Barcode Item holds
Books Books Pattoki Library
Wild Life & Ecology
Veterinary Science 615.90011 Calabrese 12445 1st 1983 Zoology (Browse shelf) Available 12445
Books Books UVAS Library
Zoology
Veterinary Science 615.90011 Calabrese 12447 1st 1983 Zoology (Browse shelf) Available 12447
Total holds: 0
Browsing Pattoki Library Shelves , Shelving location: Wild Life & Ecology , Collection code: Veterinary Science Close shelf browser
599 Beer 32720 Vol.5 2008 Wildlife Exploring the world of mammals 599 Beer 32721 Vol.6 2008 Wildlife Exploring the world of mammals 599.74428 Hes 14817 1st 1992 Wildlife Leopards of Londolozi : The Complete Book Of Tiger 615.90011 Calabrese 12445 1st 1983 Zoology Principles of Animal Extrapolation 615.902 Newman 33350 1st 2008 Wildlife Ecotoxicology: A Comprehensive Treatment 616.9363 Hide 15543 1st 1997 Zoology Trypanosomiasis and Leishmaniasis 631.52 Sirohi 31733 1st 2015 Botany Plant Breeding: Scientific Methodologies and Technologies

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

There are no comments for this item.

Log in to your account to post a comment.


Implemented and Maintained by UVAS Library.
For any Suggestions/Query Contact to library or Email:rehana.kousar@uvas.edu.pk Phone:+91 99239068
Website/OPAC best viewed in Mozilla Browser in 1366X768 Resolution.