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Antibacterial Activity Of Piroxicam And Ketorolac Alone And In Combination With Antibiotics Against Bacterial Isolates

By: Saba Shahbaz (2013-VA-852) | Dr. Muhammad Ovais Omer.
Contributor(s): Dr. Muhammad Adil Rasheed | Dr. Imran Altaf.
Material type: materialTypeLabelBookPublisher: 2015Description: 76p.Subject(s): Department of Pharmacology and ToxicologyDDC classification: 2448-T Dissertation note: Antibiotic resistance has become a global public health problem due to the excessive and indiscriminate use of antibiotics, which has resulted in many emerging multidrug-resistant microorganisms. This study is designed for the evaluation of different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline by using broth dilution method.Different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline were checked for antibacterial activity against Staphylococcusaureus and Escherichia coli.The isolates were obtained from Quality Operations Laboratory. The pathogens were tested for their sensitivity to amoxicillin and tigecycline. The sensitivity was checked by broth/tube dilution method. Dilutions were prepared by two fold dilution method.Collected data was analyzed by using statistic package for social sciences (SPSS, windows version, Chicago, IL, USA). Analysis of Variance (ANOVA) and descriptive statistics was applied.This work is designed to observe the effects of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline against bacterial pathogens to improve the quality of life of patients and will minimize the chances of infections.Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was determined by broth dilution method. The results suggested that NSAIDs enhanced the antibacterial effect when combined with these antibiotics. Combination of amoxicillin with piroxicam (9.76µg/ml+80µg/ml), and tigecycline in combination with ketorolac (0.156µg/ml+20µg/ml) was effective against Staphylococcusaureus. The combination of amoxicillin with piroxicam (9.76µg/ml+20µg/ml), amoxicillin with ketorolac (4.88µg/ml+20µg/ml), tigecycline with piroxicam (0.3125µg/ml +10µg/ml), tigecycline with ketorolac (0.312µg/ml+20µg/ml) showed efficacy against Escherichia coli.
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Antibiotic resistance has become a global public health problem due to the excessive and indiscriminate use of antibiotics, which has resulted in many emerging multidrug-resistant microorganisms. This study is designed for the evaluation of different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline by using broth dilution method.Different dilutions of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline were checked for antibacterial activity against Staphylococcusaureus and Escherichia coli.The isolates were obtained from Quality Operations Laboratory. The pathogens were tested for their sensitivity to amoxicillin and tigecycline. The sensitivity was checked by broth/tube dilution method. Dilutions were prepared by two fold dilution method.Collected data was analyzed by using statistic package for social sciences (SPSS, windows version, Chicago, IL, USA). Analysis of Variance (ANOVA) and descriptive statistics was applied.This work is designed to observe the effects of piroxicam and ketorolac alone and in combination with amoxicillin and tigecycline against bacterial pathogens to improve the quality of life of patients and will minimize the chances of infections.Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was determined by broth dilution method. The results suggested that NSAIDs enhanced the antibacterial effect when combined with these antibiotics. Combination of amoxicillin with piroxicam (9.76µg/ml+80µg/ml), and tigecycline in combination with ketorolac (0.156µg/ml+20µg/ml) was effective against Staphylococcusaureus. The combination of amoxicillin with piroxicam (9.76µg/ml+20µg/ml), amoxicillin with ketorolac (4.88µg/ml+20µg/ml), tigecycline with piroxicam (0.3125µg/ml +10µg/ml), tigecycline with ketorolac (0.312µg/ml+20µg/ml) showed efficacy against Escherichia coli.

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