02915nam a2200205Ia 4500
20150921152556.0
150525s2005 xx 000 0 und d
eng
0888,T
Aman Ullah
7208
Prof.Dr.Muhammad Ashraf
4840
Effect Of Vitamine (Alpha-Tocopherol) Supplementation On Total Lipid Profile In Rabbits
2005
An experimental trial of forty five days duration was conducted in July and August, 2004 at Physiology Department, Faculty of Bio-Sciences, University of Veterinary & Animal Sciences, Lahore. The study was conducted to see the effect of vitamin E (alpha tocopherol) on total lipid profile in rabbits. Thirty two, 2 months old white rabbits were purchased, weighed and randomly divided into four groups, comprising of eight rabbits each i.e. group A, B, C and D. The rabbits of group A were fed on normal diet and acted as control animasl. The rabbits of group B were also fed on normal diet along with replacement of 2% cholesterol. The objective to add cholesterol is to induced hypercholesterolemia artificially from the beginning of the experiment. They were orally administered cholesterol powder through disposable syringes from start to end of experiment. During the experiment these rabbits were not treated with vitamin E (alpha tocopherol). The rabbits of group C were also fed on normal diet alongwith replacement of 2% cholesterol for first fifteen days of experiment to induced hypercholesterolemia. After the induction of hypercholesterolemia these rabbits were treated with vitamin E at a dose rate of 50 mg/kg body weight. The rabbits of group D were also fed on normal diet alongwith replacement of 2% cholesterol for first fifteen days of experiment to induced hypercholesterolemia. After the induction of hypercholesterolemia these rabbits were treated with vitamin E at a dose rate of 75 mg/kg body weight. The feed for rabbits were prepared and were given with green fodder twice a day. The rabbits were reared in room carpeted with dry forage and dry soil, from the start to the end of the experiment. Standard conditions of feeding, water and temperature were maintained. The rabbits were kept in light for 24 hours throughout the experimental period. Biochemical analysis i.e. serum cholesterol, serum low density lipoprotein (LDL), serum triglycerides (TG) and serum high density lipoprotein (HDL) carried out. It was concluded that vitamin E has significant effect on total lipid profile of hypercholesterolemic rabbits. Vitamin E as an antioxidant can reduce the incidents of atherosclerosis in hypercholeterolemic rabbits and ultimately reducing the risk of heart disease in rabbits as a human model.
Department of Physiology
4504
Dr. Muhammad
4698
Mr. Shahid Abbas
5552
Faculty of Biosciences
6267
TH
2615
2615
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0
0
0888T
0
VS
3731
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2015-05-28
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