TY - BOOK AU - Amir Bakhsh AU - Dr. Muhammad Ovais Omer AU - Prof. Dr. ED - ED - Faculty of Biosciences TI - Bioavailability Of Amoxicilin Trihydrate In Broiler Chickens Administered Through Drinking Water U1 - 0894,T PY - 2004/// KW - Department of Physiology N1 - Bioavailability of two oral commercial formulations of amoxicillin trihydrate i.e. oracin-50 (Mediexcel, Pharmaceuticals (Pvt.) Limited Pakistan) and Bioxil-20 (Bioceutica, µµchickens. The birds were divided into two groups A and B and than six replicates of each group were made. The birds were reared upto 30 days. Group A was medicated by Oracin-50 and group B was medicated by Bioxil-20. The medication was continued for three consecutive days and blood samples were collected before and after medication as per schedule. The plasma level of amoxicillin were determined by microbiological assays. The concentrations versus time data were plotted on logrithmic paper and various bio-availability parameters were determined. Peak concentrations of both oral preparations appeared with in two hours. However Oracin-50 peak concentration revealed 5.26±1.605µg/ml which was not significantly higher than 4.71±0.142ig/ml as depicted by Bioxil-20. Mean ±SEM of the area under curve (AUC) for Oracin-50 was 296.783±6.331µg. hr/ml and 259.26±4.866 µg.hr/ml for Bioxil-20 statistical analyses revealed no significant different minimum concentration of Oracin-50 revealed 2.550±O.0763µg/ml while 2.450±O.07637µg/ml as depicted by the bioxil-20. Both the preparations took the same time (2 hour) to attain the peak level of the plasma concentration. The present study also revealed that amoxicillin is not much stable in water. Oracin-50 decreased 34% and Bioxil-20 decreased 35% in 72 hours There was no significant difference (P