TY - BOOK AU - Muhammad Azhar AU - Dr. Muhammad Hassan Saleem AU - Prof. Dr. Azhar ED - TI - Prevalence And Chemotherapy Of Theileriosis In Equines In And Around Lahore U1 - 1487,T PY - 2012/// KW - Department of Clinical Medicine & Surgery N1 - Theileriosis is an infectious malady of equidae characterized by intermittent fever, loss of appetite, anemia, loss of weight, dyspnea, pale mucous membranes, jaundice and recumbency. Considering the significance and utilization of equines in our country and the substantial losses rendered by theileriosis, the present study was designed to study prevalence and chemotherapy of theileriosis in equines in and around Lahore. For this purpose 300 equines (Horses=100; mules=100; donkeys=100) were examined for theileria infection.The blood was collected by ear tip puncture and from Jugular venipuncture. Then thin blood smear slide was prepared and dried up in air and stained with Geimsa's staining method and examined under microscope. Theileriaequiwere identified by their morphological characteristics as described by Rashid et al. (2009) and Guimaraeset al. (1997).Over all prevalence of Theileriaequiin equines was estimated as 58%. There was also a mixed infection of Theileriaequi and Babesiacaballiin some cases. Individually there was 54%, 64% and 56% prevalence of Theileriaequi found in horses, mules and donkeys respectively. The effect of theileriosis on various blood parameters (Hb, ESR, TEC, TLC, DLC and PCV) was determined in 30 equines (Horses= 10; mules= 10; donkeys= 10). The remarkable decrease in hemoglobin, TEC, PCV and lymphocytes was observed. The value of ESR increased while there were no remarkable changes in TLC, monocytes, basophils, neutrophils and eosinophil. For chemotherapy, 36 equines (Horses=12; mules=12; donkeys=12) positive for theileriosiswere divided into three groups (A, B, and C). Each group was further subdivided into three subgroups comprising of 4 animals in each subgroup. The animals of group A (Horses=4; mules=4; donkeys=4) were treated with Imidocarbdipropionate (Imizol®, ICI, Pakistan) @ 2 mg/kg BW I/M, and the efficacy of drug was found 91.7% in equines against theileriosis.The group B (Horses=4; mules=4; donkeys=4) was treated with Buparvaquone (Butalex®, ICI, Pakistan) @ 2 mg/kg BW I/M alone and was observed 66.7% effective. While the group C (Horses=4; mules=4; donkeys=4) was treated with Auk(Calotropisprocera)@ 0.3mg/kg BW, 8 doses at alternate days (local treatment), which was found 58.3% effective. The efficacy of drugs was measured on the basis of disappearance of clinical signs and blood smear examination at day 2, 4, 6 and 10 of post-medication. The efficacy of each drug was measured through recovery rate of the animals. Finally, the data on prevalence of theileriosis was estimated by Pearson's chi-square test for significance whereas data on hematology was analyzed by Student's T-test using statistical software package STATA 9.1 (College Station T×77845, USA), P < 0.05 was considered significant. Considering the significance and utilization of equine in our country and the substantial losses rendered by theileriosis, the present project was designed to check prevalence and chemotherapy of theileriosis in equines in and around Lahore. The results of this study will help farmers and veterinary practitioners in field ER -