1.
Formulation And Stability Evaluation Of An Optimum Opical Preparation Using Hippophae Rhamnoidesl. Oil For The Treatment of Psoriasis
by Hina Hussain | Muhammad Irfan Masood | Dr. Farzana Chowdhary | Dr. Muhammad.
Material type: ; Format:
print
Publisher: 2012Dissertation note: Multiple emulsion is a triphasic system in which the two miscible phases are separated from each other by an inner immiscible phase. In w/o/w multiple emulsion the two queous phases are separated by oily layer. Formulation and stabilization of multiple emulsions from natural oil is the difficult task due to the complex nature of the oil and poor interaction with emulsifiers. Hippophae rhamnoide L. oil, a natural oil, obtained from barries of plant belong to family Elaeagniaceae naturally found in northern areas of Pakistan is effective for healing of skin wounds, Eczema and Psoriasis. In the present study two multiple emulsions were prepared multiple emulsion base 'B' (containing Magnesium sulfate as marker substance) and multiple emulsion formulation 'F' Containing zinc sulfate as (active ingredient). Both preparations contained Hipophae rhamnoides L. oil. Both multiple emulsions were prepared using Two-step method and its stability was evaluated by observing changes in organoleptic parameters, pH, globule size, electrical conductivity and viscosity in samples kept at 4Co ,25Co, 40Co ,40Co+75% RH at various time intervals (Ohr.24hrs,48hrs,72hrs,lstweek, 2ndweek,3rd week, 4th week) for period of 28 days. Data was analyzed using ANOV A-Two ways and LSD design to see variations in parameters at time and temperature levels in each formulation kept at different storage conditions and unpaired student T-test to compare results of stability parameters of Formulation B with Formulation F . Both the multiple emulsions B' and 'F' showed phase inversion at 4°C after 24hrs of storage were excluded from further evaluation. Change in color was observed in all the samples except sample at 2SoC. Sample of multiple emulsion base 'B' kept at 40Co + 7S% RH showed liquefaction after 72 hours. Multiple emulsion formulation 'F' at 40Co and 40Co + 7S% RH showed a significant change in liquefaction and phase separation. The average globule size of multiple emulsion base 'B' (TZurn) is larger than the multiple emulsion formulation 'F' which decreased more significantly in the samples of multiple emulsion base 'B' than samples of'F'. Similarly the pH of the multiple emulsion 'B' (S.l) is more than 'F' (4.2) but in both multiple emulsions kept at different temperatures increased significantly. The increase in electrical conductivity and decrease in viscosity of both multiple emulsions 'B' and 'F' was rather more at 40°C and 40°C+ 7S%RH temperatures while this change was comparatively more in multiple emulsion 'F'. So multiple emulsion 'B' and 'F' at 25°C were stable with respect to organoleptic parameters (except liquefaction), centrifugation, globule size, pH, electrical conductivity and viscosity change than at other temperatures (40°C and 40°C + 7S% RH). Multiple emulsion 'F' is rather more stable at 25°C than 'B' as no liquefaction occurred during the whole stability period in 'F'. For multiple emulsions from Hippophae rhamnoide L. oil refrigeration and high temperature storage condition is fatal for the stability and for relatively high shelf life formulation must be stored at room temperature. Multiple emulsion has advantages over simple emulsion as the droplets may act as reservoir for entrapping the drug molecules to release them slowly to the outer continuous phase so the advantages of multiple emulsion are i) the protection of material entrapped in the internal phase ii) more than one incompatible components can be formulated in a single preparation. None of the multiple emulsions for dermal applications has yet been available in Pakistani market so keeping in view the advantages of multiple emulsion and the Hippophae rhamnoides L. oil prospective researchers hereby suggested to manufacture such a stable formulation which can effectively be marketed in this region.
Availability: Items available for loan: UVAS Library [Call number: 1403,T] (1).
2.
Pharmacokinetics Of Carvedilol In Dogs After Oral Administration
by Khurram Wajih Mahmood | Ms. Huma Rasheed | Dr. Mateen | Dr. Sualeha Riffat.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2011Dissertation note: Carvedilol, is a class-II, non-biowaivered drug, with low solubility. It is a candidate for several in-vivo studies including bioavailability and bioequivalence of generic versus standard, and also for testing performance of modified release products. Single dose pharmacokinetic study was performed on 12 healthy dogs using 25mg Carvedilol tablets. The objective of this study was to perform pharmacokinetic and biopharmaceutic study in the dog model for Carvedilol. The animals were selected after screening by veterinary practitioner. Blood samples were collected after 15min, 30min, 1 hr, 1.5 hr, 2 hrs, 4 hrs, 6 hrs, 8 hrs, 12 hrs and 24 hrs via an in-dwelling catheter from the cephalic vein of the animals along with one base line sample taken before drug administration. The plasma samples obtained by centrifugation were analyzed by HPLC quantitative method after checking the reproducibility and linearity of the standard curve using the standards prepared in dog plasma. Pharmacokinetic parameters were calculated by using APO software, and using appropriate compartmental pharmacokinetic model. The data derived from this study was analyzed using descriptive statistics and the observed results were compared with the published literature. The pharmacokinetic parameters investigated show that peak plasma concentration was 72.33±32.84 ng/ml, elimination half life of 1.84±2.42 hrs, Mean Residence Time was 2.98±0.96hrs, Volume of distribution of 0.57±0.6 l/kg and time to peak plasma concentration of 1.77±0.31hrs. The study defends the older proposition by pharmacokineticists that the Carvedilol shows unpredictable absorption kinetics in dogs and a few of the parameters also relate with the published finding on the Carvedilol pharmacokinetics in human. The delay in absorption and significant lag time of 1.23hrs was consistent in all subjects. The study elaborated the prospects of the possibility of using animal studies to achieve predictable pharmacokinetics of the drugs without involving human subjects.
Availability: Items available for loan: UVAS Library [Call number: 1423,T] (1).
3.
Identification Of Potential Drug-Drug Interactions In Prescriptions Dispensed By Community Pharmacies In The Urban
by Muhammad Mubasher | Ms. Huma Rasheed | Muhammad Irfan Masood | Prof. Dr.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2011Dissertation note: Pakistan is a developing country of South Asia and health care status of the people is considerably low compared to the developed countries of World. The concept of rational prescribing is still not fully understood by health care professionals of this region of the world. This study was designed to identify the most frequently encountered potential DDIs in prescriptions dispensed in community pharmacies in Lahore. A total of 1554 DIs were identified in 655 prescriptions out of 1000 analyzed prescriptions. The identified drug interactions were classified on the basis of their type, mechanism and outcome, severity, onset, and documentation status. It was observed that alcohol-drug interactions 582 (37.45%) and DDIs 524 (33.72%) are the most frequently occurring drug interactions in our society. Although most of the identified DDIs were moderate 233 (44.38%) in severity having delayed onset 230 (43.89%) and possible documentation 214 (40.84%), incidence of rapid onset 171 (32.63%), major DDIs 88 (16.76%) was also alarming in prescriptions dispensed at community pharmacies of urban Lahore. Aspirin was the most frequently interacting drug 138 times (26.34%) and acetaminophen-orphenadrine combination with 53 (10.91%) encounters was the top interacting combination followed by aspirin-clopidogrel combination. The incidence of DDIs increased significantly with increase in the number of medicines (r value = 0.87) in a prescription. On the basis of findings, recommendations that how potential DDIs can be avoided were made.
Availability: Items available for loan: UVAS Library [Call number: 1431,T] (1).
4.
Evaluation Of Good Pharmacy Practice In Community Drug Sale Outlets With "A" Category License In The Urban Lahore,
by Muhammad Shahwar | Ms. Huma Rasheed | Muhammad Usman | Prof. Dr.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2011Dissertation note: Pakistan is a developing country, facing many challenges regarding provision of quality health to its people. Community drug sale outlet is the premises where people buy their prescription and Over the Counter (OTC) medicines. Internationally, the concept of community pharmacy is now far beyond the supply of medicines. It also includes drug information services and provision of pharmaceutical care. The international guidelines established for Good Pharmacy Practices (GPP) by WHO and International Pharmaceutical Federation (FIP) provide stepwise GPP implementation plans for developing countries. This project was designed for the evaluation of the current pharmacy practices at community pharmacies of Lahore on basis of WHO/FIP guidelines. This assessment was based on 50 indicators in form of survey which fulfills almost all areas of community pharmacy practice. Questionnaire was filled through the verbal communication with drug sale outlet personnel. Total of 200 drug sale outlets were selected on simple random sampling basis from the different areas of urban Lahore. The collected data was used to categorize the drug sale outlets on basis of score in four grades. The drug sale outlets were graded in four categories (A, B, C, and D) according to results obtained. Drug sale outlet having percentage up to 25 were graded D category; drug sale outlet having percentage 26-50 will lie in B category, drug sale outlet having percentage 51-75 and above 75 were graded in A category. 88% of drug sale outlets secured below 50% of the total score .The data was analyzed using descriptive statistics. This was a base line study regarding GPP in Pakistan. GPP guidelines for pharmacy practices need to be established in Pakistan. Ministry of health and current legislation should play a major role in developing these guidelines. Qualified pharmacist should personally supervise the drug sale outlet all the time, to enhance the rational use of drugs, and to take part in provision of health care at community level. The compounding and dispensing section in current community drug sale outlets has a lots of improvement to be done regarding formulation personally by pharmacist and supervision also the compounding and dispensing section premises have to be separate from major area as per law other major areas identified by this study that require improvement include training, premises, storage
system, and service.
Availability: Items available for loan: UVAS Library [Call number: 1432,T] (1).
5.
Comparison Of Dsingle-Dose Pharmacokinetics Of Candesartan Cilexetil In Healthy Male & Female
by Hafiz Awais Nawaz | Muhammad Irfan Masood | Dr. Mateen | Dr. Sualeha Riffat.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2012Dissertation note: This study was designed to compare the pharmacokinetic parameters of Candesartan in 8 healthy male and female volunteers. The study was conducted in eight healthy male volunteers and eight healthy female volunteers. Only those male volunteers were selected who aged between 18-30 years, not suffering from any disease. Female volunteers were also between age of 18-30 years, who were not pregnant and not suffering from any disease. Written consent was taken from them and they were informed about objectives of the study, frequency of blood sampling, and possible side effects of drug which they might face during the study. The male volunteers were considered as group A and healthy female volunteers were considered as group B. Both groups were administered Candesartan 16mg tablet orally to each individual. 5ml Blood samples were collected at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 12, 24, 48 & 72 hr after the oral drug administration from vein through 5ml B.D syringe of 22guage needle. Plasma was separated by centrifugation at 5000 RPM and stored at -80ºC till analysis. Candesartan concentrations in plasma were measured by HPLC method. All pharmacokinetic parameters were calculated by entering plasma concentration-time data in software APO pharmacological analysis MW/PHARM version 3.02 by assuming bio-availability of Candesartan after oral administration as 1. Pharmacokinetic parameters of Candesartan in healthy male and female volunteers were compared. Data was analyzed by unpaired t-test and it was observed that there is significant difference in AUC of Candesartan in healthy male and female volunteers after oral administration without any effect in Cmax, Tmax, volume of distribution, absorption rate constant or elimination half life. In general, candesartan produced comparable results in healthy male and female volunteers so there is no need of any dose adjustment during therapy in both genders.
Availability: Items available for loan: UVAS Library [Call number: 1442,T] (1).
6.
Evaluation Of Prescribing Practices And Management Outcomes Of Pre-Eclampasia/Eclampsia In Lahore
by Shumaila Sarwar | Milk Allah Bukhsh Awan | Syed Muhammad Anjum.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2013Dissertation note: Pre-eclampsia is a disorder that involves many systems of the body and occurs after 20th week of pregnancy. It is usually associated with high blood pressure (>140/90 mmHg) and proteinurea. Pre-eclampsia if untreated, can lead to eclampsia which is associated with convulsion and can prove fatal for both mother and fetus. Magnesium sulphate is considered now the drug of choice for the prophylaxis and treatment of convulsions in eclampsia. WHO has declared magnesium sulphate as most effective and low cost anticonvulsant drug for pre-eclampsia and eclampsia. This study was designed to evaluate the current prescribing practices and management outcomes of pre-eclampsia/eclampsia in tertiary care hospitals in Lahore. Data collection form was used to collect data related to patient demographics, history, lab findings, prescribing indicators, drug administration record, side effects, toxicity, measures to combat toxicity and outcome. Collected data was analyzed using descriptive statistics with the help of statistical software SPSS 17. The findings of our study clearly show that magnesium sulphate is being successfully used for management of eclampsia and to some extent for pre-eclampsia at tertiary care hospitals in Lahore. However there is lack of specific institutional guidelines on dose, timing, and indications, particularly in case of severe pre-eclampsia before 38th weeks of gestation, in which delivery was not imminent. Most of the health care professionals lack training and experience of the drug use. National as well as institutional guidelines need to be developed, implemented, monitored and evaluated for management of pre-eclampsia/eclampsia. Health professionals at all levels of care need to be provided in-service training for management of the disease.
Availability: Items available for loan: UVAS Library [Call number: 1655,T] (1).
7.
Preaparation And In Vitro Evaluation Of Nystatin Microemulsion Based Gel
by Iram Maqsood | Muhammad Irfan Masood | Hafiz Muhammad Awais Nawaz.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1661,T] (1).
8.
Formulation And In Vitro Evaluation Of Sustained Release Matrix Tablets Using Crossed Linked Natural Gums
by Qurratulain Jamil | Muhammad Irfan Masood | Dr. Aonia Khiljee | Dr. Aqeel.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1689,T] (1).
9.
A Cross Sectional Dtudy To Evaluate The Quality Of Community Pharmacy Services
by Irum Iftikhar | Dr. Sonia Khiljee | Malik Allah Bukhsh Awan | Prof. Dr.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2011-13Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1709,T] (1).
10.
Formulation And In Vitro Envaluation Of Microemulsion Based Transdermal Gel For Miconazole
by Iram Shahzadi | Muhammad Irfan Masood | Hafiz Muhammad Awais Nawaz.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1713,T] (1).
11.
Formulation And In Vitro Evaluation Of Natural Gum Based Glipizide Sustained Release Matrix Tablets
by Saleha Khalid | Muhammad Irfan Masood | Dr. Aqeel | Muhammad Naeem.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1724,T] (1).
12.
Formulation Of Honey And Propolis Based Microemulsion Gel And Its Effects On Burns
by Shazia Ishaque | Dr. Sonia Khiljee | Dr. Muhammad | Malik Allah Bukhsh Awan.
Material type: ; Format:
print
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1726,T] (1).
13.
Formulation Of Microemulsion Containing Nigella Sativa Honey And Propolis, And Evaluation Its Burns
by Faizah Sulaiman | Dr. Sonia Khiljee | Dr. Muhammad | Muhammad Irfan Masood.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1738,T] (1).
14.
Availability Of Antidotes And Key Emergency Drugs In Tertiary Care Hospitals Of Punjab And Role Of Health
by Naheed Arslan | Dr. Sonia Khiljee | Malik Allah Bakhsh Awan | Prof. Dr.
Material type: ; Format:
print
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1772,T] (1).
15.
Invitro Evaluation Of Microemulsion Containing Extract Of Lawsonia Inermis
by Aysha Aslam | Dr. Sonia Khiljee | Allah Buksh Awan | Dr. Muhammad.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: The objective of the present study is to develop an optimum microemulsion formulation of Lawsone, for transdermal delivery. This study also investigated the effects of surfactants and cosurfactants and oils on the percutaneous delivery of Lawsone microemulsion. Oleic acid was selected as the oil phase, Tween 80 as surfactant and Ethanol as cosurfactant of the microemulsion due to its good solubilizing capacity for the drug. The microemulsion area was identified by constructing Pseudoternary phase diagrams with different surfactant-cosurfactant mixtures (Smix) and oil. 5% Lawsone microemulsion was prepared. Transdermal permeation of Lawsone microemulsion was determined in vitro using Franz diffusion cell. In vitro permeation profiles showed that incorporation of Lawsone in microemulsion increased the permeation rate as compared to the saturated aqueous solution. The formulation passed thermodynamic stability tests were characterized for viscosity, pH and conductivity. In vitro skin permeation of these formulations was also determined. The optimum microemulsion formulation comprised of 5% Lawsone, 5% Oleic acid, 95% Tween 80 and ethanol (1:1). The formulation was found to be non-irritant to the skin. These results indicate that the type of surfactant and cosurfactant affect both the phase behaviour and transdermal drug delivery ability of microemulsion; and the studied microemulsions are potential vehicles for improved transdermal delivery of Lawsone.
Keywords: Transdermal microemulsion, Lawsone, Surfactants, Cosurfactants.
Availability: Items available for loan: UVAS Library [Call number: 1773,T] (1).
16.
Formulation Of Microemulsion Based Gel Of Hippophae Rhamnoides And Its In Vivo Evaluation On Burn Healing
by Hira ayub | DR. Sonia khiljee | Muhammad irfan masood | Prof. Dr.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2031,T] (1).
17.
Assessment Of Bioerodible Polymers As Rate Conteolling Matrix For Sustained Release Of Quetiapine Fumarate
by Sadia urooj | Hafiz awais nawaz | Dr. Aqeel | Muhammad irfan masood.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2032,T] (1).
18.
Evaluation And Monitoring Of Therapeutic Outcomes In Chronic Hepatitis C Patients With Interferon And Ribavirin
by Ghazala rafique | Malik allah bukhsh | Dr. Sonia khilji | Prof. Dr. Muhammad.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2043,T] (1).
19.
Formulation And Evaluation Of Floating Matrix Tablet Of Mefenamic Acid
by Khanzada atta-ur-rehman khan | Muhammad Naeem | Malik allah bukhsh awan | Prof. Dr.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2066,T] (1).
20.
Remington the science and practice of pharmacy / 21st ed.
by Remington.
Edition: 21st ed.Material type: ; Format:
print
; Literary form:
not fiction
Availability: No items available In transit (1).
21.
Essential Of Biochemistory
by Mushtaq Ahmad.v.
Material type: ; Literary form:
not fiction
Availability: No items available Checked out (1).
22.
Medical and aromatic crops harvesting drying and processing / 1st ed.
by Oztekin-Serdar.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New York: Harwoth food & Agriculture product press; 2007Availability: No items available Checked out (1).
23.
Textbook of Pharmaceutical Dispensing
by Goyal, Amit K.
Material type: ; Format:
print
; Literary form:
not fiction
Availability: No items available In transit (1).
24.
Practical Microbiology / 1st ed.
by Dubey, R.C.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: S Chand & Company; 2002Availability: Items available for loan: IPS Library [Call number: 615.1 Dubey 19253 1st ed. 2002 IPS] (1), UVAS Library [Call number: 615.1 Dubey 19252 1st ed. 2002 Microbiology] (1).
25.
Encyclopaedia of World medicinal plants / 1st ed.
by Pullaiah-T.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: Regency Publishers; 2006Availability: Items available for loan: IPS Library [Call number: 615.1 Pullaiah V.1 20443 1st ed 2006 IPS] (1), UVAS Library [Call number: 615.1 Pullaiah V.1 20448 1st.ed 2006 Pharmaceutics] (1).
26.
Encyclopaedia of World medicinal plants / 1st ed.
by Pullaiah-T.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: Regency Publishers; 2006Availability: Items available for loan: IPS Library [Call number: 615.1 Pullaiah V.5 20447 1st ed 2006 IPS] (1), UVAS Library [Call number: 615.1 Pullaiah V.5 20452 1st ed 2006 Pharmaceutics] (1).
27.
Encyclopaedia of World medicinal plants / 1st ed.
by Pullaiah-T.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: Regency Publishers; 2006Availability: Items available for loan: IPS Library [Call number: 615.1 Pullaiah V.4 20446 1st ed 2006 IPS] (1), UVAS Library [Call number: 615.1 Pullaiah V.4 20451 1st ed 2006 Pharmaceutics] (1).
28.
Encyclopaedia of World medicinal plants / 1st ed.
by Pullaiah-T.
Edition: 1st ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: Regency Publishers; 2006Availability: Items available for loan: IPS Library [Call number: 615.1 Pullaiah V.2 20444 1st ed 2006 IPS] (1), UVAS Library [Call number: 615.1 Pullaiah V.2 20449 1st ed 2006 Pharmaceutics] (1).
29.
Lippincott's Illustrated reviews Pharmacology With Online Access / 5th ed.
by Harvey, Richard.
Edition: 5th ed.Material type: ; Format:
print
; Literary form:
not fiction
Availability: Items available for loan: IPS Library [Call number: 615.1 Harvey 29905 5th ed. IPS] (19). In transit (1).
30.
Remington, the sciences & practic of pharmacy / 21th ed.
by Beringer, Paul.
Edition: 21th ed.Material type: ; Literary form:
not fiction
Publisher: New Delhi: Lippincott William &Wilikins. 2009Availability: Items available for loan: IPS Library [Call number: 615.1 Paul Vol 2 23464 21th ed 2009 IPS] (4). In transit (1).
31.
Hospital Pharmacy / 1st ed.
by Nadeem Irfan Bukhari.
Edition: !st ed.Material type: ; Literary form:
not fiction
Publisher: Lahore: Aziz Book Depot; 2000Availability: Items available for loan: IPS Library [Call number: 615.1 Nadeem Irfan Bukhari 23955 1st ed 2000 IPS] (9). In transit (1).
32.
Basic and clinical pharmacology / 10th ed.
by Katzung, Bertram G.
Edition: 10th ed.Material type: ; Literary form:
not fiction
Publisher: Boston: MeGraw Hill; 2007Availability: Items available for loan: IPS Library [Call number: 615.1 Katzung 19868 10th ed. 2007 IPS] (8). In transit (1).
33.
Bentley's Textbook of Pharmaceutics / 8th ed.
by Rawlins-E.A.
Edition: 8th ed.Material type: ; Literary form:
not fiction
Publisher: 2005. New Dehli: Bailliere TindalAvailability: Items available for loan: IPS Library [Call number: 615.1 Rawlins 20366 8th ed 2005 IPS] (11). In transit (2).
