2.
Comparative Ealuation Of Melia Azadarch Linn (Neem) For Control Of Coccidiosis In Poultry (Broiler)
by Fouzia Iqbal | Dr. Muhammad Sabir | Dr. Mubasher | Dr. Muhammad Arshad Qureshi.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 1993Dissertation note: A study was conducted to evaluate the anti-coccidial activity of Melia azadarch Linn (Neem) , an indigenous plant drug in comparison to synthetic coccicliostats (Esb3) in broilers.
The Meli azadarch Linn (Neem) seed was tried in powder, aquous extract and methanolic extract for anti-coccidial activity in broilers. The birds were artificial infected with coccidial oocyst at the age of 30 days. After 5 days of infection the oocyst counting was carried out in the droppings of the birds. When evidence of coccidiosis outbreak in the infected birds was established than the drug was administered to different groups of the broilers. The group A was kept as control, group B, C & D were administered Powder Melia azadarch Linn (Neem) 10, 20 & 30 mg/Kg body weight respectively and group F was given Esb3, to compare the effect of this plant drug. Similarly aquous extract and Methanolic extract was administered equivalent to 10, 20 & 30 mg/Kg B.W. of Melia azadaich Linn (Neem) to respective group. The OPG (oocyst per gram) was examined after 3, 10 & 15 days after the drug administration. It was observed that OPG (oocyst per gram) was decreased to 0.59%, 0.78% and 0.58% at the dose rate of 10, 20 and 30 mg/Kg 13.W. respectively after 3 clays of treatment with Melia azadarch Linn Powder. Whereas it was reduced to 82.79% in group E treated with Esb3. After 10 days of treatment OPG was decreased to 50.17% and 96.55% in groups B, C, D & E respectively at the dose rate oF 10, 20 & 30 mg/Kg [3.W. in case of Melia azadarch Linn (Powder) and lsb1. After 15 days OPG was decreased to 97.94%, 97.08%, 97.87 and 98.60% in group B, C, D & E respectively in case of Melia azadarch Linn (Powder) at the dose rate of 10, 20 and 30 mg/Kg 13.W. and Esb3. at dose rate of 1g/liter.
In case of Melia azadarch Linn (Neern) (Water extract) OPG reduction after 3 days of treatment was 4.46%, 3,93% and
3.67% in groups B, C and 1). While OPG reduction in case of group E was 83.82%.
After 10 days of post treatment OPG counting was 5 1.33%, 51.18%, 51,10% and 96.76 in groups 13, C, 1) and E respectively. In case of OPG counting after 15 days reduction was 90.62%, 86.61%, 79.77% and 98.30% in groups 13, C, I) and l respectively. Dose rate of group B, C, & 1) is equivalent to 10, 20 & 30 mglKg B.W. and group E ig/liter i.e. Esb3:,.
In case of group treated with Melia azaclarch Linn (Neem) (methanolic extract, OPG reduction after 3 days of treatment was 0.59%, 0.78%, 0.58% and 82.79% in groups B, C, D & E respectively. In case OPG counting after 10 days of treatment was 50.17%, 50.23%, 50.17% and 96.55% in groups B, C, D & E respectively. While OPG counting after 15 clays of treatment was 97.94%, 97.08%, 97.87% and 98.60% in groups B, C, D & E. Dose rate of group B, C, D was equivalent to dose rate of 10, 20 and 30mg/kg .B.W. & group E was t ieated with I1sb at dose rate of ig/liter.
It is concluded that. Melia azadarch Linn (Neem ) is equally effective against coccidiosis in powder, aquous and methanolic extract. Although it took longer to produce similar effect as Esb3 but it is quite comparable with the results shown by 1sb. In addition the Melia azadarch linn (Neem). in either from did not show any adverse effect on the growth rate of the broilers. Any how this plant material can be used as prophylactic measures or to treat the outbreak of coccidiosis. Certainly there is a need for investigation to make this drug more efficacious.
Availability: Items available for loan: UVAS Library [Call number: 0384,T] (1).
3.
Adverse Effects Of Kanamycin In Dwarf Goats (Teddy Goats)
by Atta Ullah, M | Dr. Muhammad Sabir | Dr. Haji Ahmad | Dr. M. Arshad Qureshi.
Material type: ; Format:
print
Publisher: 1995Dissertation note: Kanamycin, an aminoglycoside antibiotic is commonly employed as a therapeutic agent for the treatment of many infectious diseases.
Goat farming is considered to be more profitable than other farm animals. Especially the
Teddy goats are abundently kept in plains and mountaneous and barani, areas of Pakistan on account of their rapid growth, early maturity and higher rate of twins, triplets in this species.
An experiment was conducted to observe the influence of kanamycin sulphate on the haematologic and enzymatic activity in teddy goats.
In this experiment kanamycin sulphate was injected to the goats at the dose rate of 10 mg/kg body weight twice daily for five successive days. The blood sample were taken after one week and then once a week for four weeks of injection The sera thus collected were subjected to analytical examination.
The study indicated the significant increase in the total number of erythrocytes and leukocytes. The packed cell volume and the haemoglobin concentration did not change
significantly. The activity of alkaline phosphatase, alanine aminotransferase (OPT), aspartate aminotransferase (GOT) was also estimated'. The alkaline phosphatase activity was enhanced during the experimental period which returned to normal at the end of the experiment. The value of OPT activity increased after the first week of injection and persisted through out the experiment, althou9h it decreased in the later stages of study.
On the basis of the observations made during this study, it is suggested that kanamycin do have damaging effect on the liver which has resulted in an increased activity of ALP, OPT and GOT.
The increase in the number of erythrocytes and leukocytes during this study might be due to the increase in haemopiosis, resulting in the production of immature blood cells.
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4.
Antibacterial Activities Of An Antibiotic On Complexation With Metals
by Abid Riaz Ahmed | Dr. Muhammad Sabir | Dr. Khushi Muhammad | Mr. Razzaq Ali.
Material type: ; Format:
print
Publisher: 1997Dissertation note: The work presented in this thesis concerns the role of metal ions through chelation in drug design. The area received much attention since the claim that the complexes of drug substances with metal ions are more active and less toxic than the parent drug.
In this work complexes of cephalexin with copper and zinc ions were prepared and characterized by microanalysis, IR and UV-vis spectrophotometry, magnetic measurement techniques, differential scanning calorimetry, and atomic absorption spectrometry. The complexes were found to be of ML2 type where M is the metal ion and L stands for the ligand. Both the complexes were monohydrate. On the basis of the analytical and spectroscopic data, the copper complex is suggested to possess an elongatedtetragonal copper (II) ions environment with d22 ground state, the complex was found to be mononuclear with respect to copper atom. The zinc complex possessed square-pyramidal geometry having coordination number 5.
The complexes were found to be much more active (copper complex possessed about four times enhanced activity, zinc complex about three times higher activity) against S. aureus. Similarly copper complex possessed 14 times higher activity and zinc complex about 10 times higher activity against E. coli.
This work presents a major advance to the pharmaceutical sciences. The complexes reported in this study may replace cephalexin in daily use due to their higher activities against the micro-organisms sensitive to cephalexin.
Availability: Items available for loan: UVAS Library [Call number: 0544,T] (1).
5.
Protective Effect Of Indomethacin On Alloxan Induced Diabetes In Rabbits
by Razaq Waria, M | Dr. Muhammad Sabir | Dr. Haji Ahmad | Dr. Muhammad Razzaq Ali.
Material type: ; Format:
print
Publisher: 1998Dissertation note: An investigation was undertaken to study the protective effect of indomethacin and powdered Cuminum nigrum Linn. Seeds (Kala zeera) on alloxan induced diabetes in rabbits.
Thirty healthy rabbits were kept in animal house of College of Veterinary Sciences, Lahore. These rabbits were randomly divided into six groups A, B, C, D, E and F comprising of 5 rabbits in each and were provided food and water aci-libitum.
Group A was kept as control which was given alloxan (150mg/Kg body weight) without prior administration of indomethacin or Kala zeera. Group B rabbits were given 10 mg/Kg body weight indornethacin intraperitoneally, 15 minute prior to alloxan administraiton intravenously of 150mg/Kg body weight. Group C was given 20mg/Kg body weight of indomethacin intraperitoneally 15 minute prior to alloxan administration intravenously of 150mg/Kg body weight. Group D rabbits were given powdered Cuminum nigrurn 2gm/Kg body weight orally 2 hours prior to alloxan administraiton intravenously of 150mg/Kg body weight. Group E was given only 10mg/Kg body weight of indomethacin intrperitoneally and its effect was noted. Group F was given only 25mg i.e. 0.5m1 NaHCO3 5% intraperitoneally to see its effect.
The animals were sampled for glucose and protein estimation after zero 24, 48 and 72 hours. Before taking the samples animals were fasted overnight. Their blood glucose levels were estimated by glucorneter and total serum protein was estimated by Biuret method. Group A showed marked increase of blood glucose level and had not effect on total protein. Group B did not show protective effect on blood glucose level and no change in total serum protein level, while group C showed significantly protective effect on the blood glucose level and no change in total serum protein level. Group D showed marked increase of blood glucose level and did not show any protective effect and also no change in total serum protein level. Group E and F showed significant increase of blood glucose level but increased level remained in the normal limit and no change in total serum protein.
It is clear that indomethacin showed dose dependently protective effect on alloxan induced diabetes in rabbits but herbal medicine Cuminum nigrum has no protective effect. It is also clear that there in no change in total serum protein level even in severe diabetic condition.
Availability: Items available for loan: UVAS Library [Call number: 0578,T] (1).
