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Immunomodulatory Effects Of Chloramphenicol In Broiler Chicks

by Zubair Ulass | Dr. M. Akram Munir | Dr. M. Naeem | Dr. M. Sarwar Khan | Faculty of Veterinary Sciences.

Material type: book Book; Format: print ; Nature of contents: biography; Literary form: Publisher: 1998Dissertation note: The purpose of the present study was to evaluate effects of chioramphenicol on the inimune response of broiler chickens. The immuno-modulatory effects of chioramphenicol in chicks was evaluated using the following parameters: a) Morphometric effects of chioramphenicol on immune organs such as Li ursa of Fabricius, Tliymus and Spleen. b) Effects of cliloramphenicol on the development of antibody titres against Newcastle virus vaccine. c) Potential of chioramphenicol treated and NDV vaccinated birds to resist virulent NDV challenge. d) Comparison of body weight gains of chioramphenicol a iid treated and untreated birds. The untreated control birds had higher mean body weight than chioramphenicol and cyclophosphamide treated birds. Chioramphenicol treatment adversely affect the weight of bursa of Fabricius , spleen and thymus of birds. The normal dose of chioramphenicol slightly depressed the weight of immune organ than double dosage of chioramphenicol. Cycloposphamide treatment of birds in early life resulted in bursal atrophy and slight depression of splenic weight. The sera of untreated control vaccinated birds had higher antibody titres than chioramphenicol and cyclophospliatnide treated birds. The sera of chioramphenicol treated NDV vaccinated birds had lower antibdoy titres as compared to untreated control birds. The NDV vaccinated choramphenicol treated and NDV vaccinated cyelophosphamide treated birds had high post Nl)V challenge mortality than untreated control NDV vaccinated birds. Availability: Items available for loan: UVAS Library [Call number: 0556,T] (1).

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Immunomodulatory Effect Of Brucella Abortus Vaccine Strain Rb51 In Cross Bred Cows At Private Farms In Lahore

by Shafique, M | Dr. Imtiaz Hussain Khan | Dr. M. Akram Munir | Dr. M. Aleem | Faculty of Veterinary Sciences.

Material type: book Book; Format: print Publisher: 1999Dissertation note: This project was designed to eradicate dangerous problem (Brucellosis) facing by livestock sector. Various trials of vaccine SRB51 were conducted and serum samples were taken to see the immune status of the animals by using serum tube agglutination test (STAT). For this purpose 100 animals of different age groups were examined and lactating or non lactating animals were randomly selected from different private dairy farms in and around Lahore. The serum samples were collected and subjected to serological tests to detect the presence of antibodies against brucella abortus. The incidence of brucellosis by RBPT was 16% and 14% by Standard tube agglutination test (STAT) in cattle. After screening the animals, we got 30 animals which were brucella abortus free, among these some animals were pregnant. We vaccinated the animal at neck region subcut with Brucella abortus strain RB51 vaccine. After vaccination we found that antibody titer was higher at four weeks and begins to lower at eight weeks and later on, by using STAT. We also observed in this study that no animal was aborted and no premature or weak calf was delievered at parturition. So it can be said that the Brucella abortus strain RB51 vaccine is a safe vaccine and it has been used in a lot number of states of America. The results of this study have revealed an alarming prevalence of brucellosis in cattle at private farms which calls for an emergent response of experts for reappraisal and reassessment of the present brucellosis control situation, especially when the disease is an important zoonosis and potential threat to the human health. It is anticipated that the trials would open new vistas and expose livestock (Dairy) scientists to new horizons of technical know how regarding brucellosis and associated problems. It is further hoped that the results obtained would make tangible contribution towards livestock and dairy industry. Availability: Items available for loan: UVAS Library [Call number: 0589,T] (1).

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Preparation And Evaluation Of A Cell Culture Contagious Pustular Dermatitis Virus Vaccine

by Shahida Afzaal | Dr. M. Ajmal | Dr. M. Akram Munir | Dr. T.M. Khan | Faculty of Veterinary Sciences.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1990Dissertation note: The present study was conducted to prepare a cell culture vaccine against CPD to repice the older vaccine so as to induce an effective level of immunity and thus to reduce the economic losses caused by this malady. A local CPD virus strain, isolated from a direased goat during an outbreak occurred at 11.E.S. Bahadurnagar, was adapted on primary lamb kidney cells by giving several successive passages. The isolated virus was confirmed in vivo by known goat pox as well as CI']) viruses and Was used for vaccine production. Confluent primary monolayer of lamb kidney cells was achieved after 5 day of incubation. Viral material after its adaptation on kidney cells at sixth passage was inoculated on monolayer for production of vaccine. When 80% of the cells showed CPE after 6-8 days of post inoculation, the culture bottles were removed and stared at -20°C. After complete freezing, the culture bottles were thawed rapidly with vigorous shaking to disrupt the cells. The titre of the pooled virus ws found to be 10-4 in kidney cells. 5 percent suspension of the titrated virus was made in Alum Gel to prepare the vaccine. The CPD local virulent virus strain was used for challange purpose. Its titre was calculated and found to be io4.16 in susceptible goats. Sterility of the vaccine waS done on different culture media and safety was carried out in guinea pigs by inoculating the vaccine intramuscularly. The potency of the vaccine W&S done in susceptible goats( Tlilk teeth). The goats which were vaccinated in 10 ml and I ml dosage subcutaneously, and challanged after 14 days of vaccination with I ml of challange dose of 100 RD50 and 1000 RD50, proved to be immune by withstanding the above challange dose. This cell culture CPD vaccine is being used in the field with encouraging results. Availability: Items available for loan: UVAS Library [Call number: 1129,T] (1).

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