UVAS Library

Your cart is empty.

Your search returned 2 results. Subscribe to this search

Not what you expected? Check for suggestions
Unhighlight Highlight
|
1.
No cover image available
Anthelmintic Activity Of Withania Coagulans Against Gastrointestinal Nematode Of Sheep In District Killa Saifullah, Baluchistan

by Yousaf Gul (2009-VA-145) | Dr. Muhammad Lateef | Dr. Saadullah Jan | Dr. Muhammad Imran Rashid | Dr. Wasim Shehzad.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: Evaluation of anthelmintic activity of Withania coagulans was studied against GIT nematodes of sheep in district Killa Saifullah Baluchistan. Sheep of the district were screen out for the presence of GIT nematodes. Animal positive for GIT nematodes and having 150+ Egg per Gram (EPG) of feces was included in the drug trial. Animals were treated with extract(s) of locally available herbal plant (withania coagulans) and levamisole. Two types of plant formulations that is crude powder and crude methanole extract were prepared each with various dosages. The effect of both medicinal plant and levamisole was observed on different groups of animals and the results were analyzed with appropriate statistical tool. Eighty animals were randomly divided in to eight groups (10 animals in each group) i.e. A, B1, B2, B3, C1, C2, C3 and D. Animals in group A served as control untreated group. Animals in groups B1, B2 and B3 were treated with crude powder of Withania coagulans at the dose rate of 1, 2 and 3 g/kg body weight respectively. And Animals in groups C1, C2 and C3 were treated with crude methanol extract of Withania coagulans at 33.3, 66.6 and 100mg/kg equivalent dose rate of 1, 2 and 3 g/kg body weight respectively. Animals in group D were given Levamisole at the standard dose rate of 7.5 mg/ kg body weight. Data was analyzed by using SPSS version 20.0; comparative analysis was done by applying ANOVA. P value <0.05 was taken as significant. The analyzed data and the results revealed that Levamisole is still a better anthelmintic against ovine nematodes in district Killa Saifullah Balochistan. Efficacy of levamisole tested for 15 days in-vivo sheep was up to 92%. This efficacy was much higher than the various forms and dosages of medicinal plant. The efficacy of Levamisole was significantly higher (P<0.05) than all forms and dosages of medicinal plant. Group C3 treated with crude methanol extract of Withania coagulans at the dose rate of 10mg/kg equivalent to 3mg/kg showed highest efficacy of the plant that is up to 48%. The efficacy showed by the form of the medicinal plant used in group C3 against ovine GIT nematodes was significantly higher (P<0.05) than all other forms of the plant. Animals in group B1, B2, B3, C1 and C2 showed anthelmintic efficacy of 19.47%, 23.58%, 31.66%, 31.76% and 33.33% from day 0 to day 15th post-treatment. Gastrointenstinal nematodes of sheep have produced anthelmintic resistance against Levamisole at the dose rate of 7.5mg/kg. In previous studies Levamisole had showed efficacy of 99.99%, 99% and 98%. It is therefore recommended that further investigation on huge scale should be passed out concerning a great number of animals, quantities higher than those used in the present study, documentation of active principles, and calibration of dose and toxicity studies for drug development from the herbal plant. Availability: Items available for loan: UVAS Library [Call number: 2688-T] (1).

Place hold Add to cart
2.
No cover image available
Anthelmintic Activity Of Euphorbia Plant Against Gastrointestinal (Git) Nematodes In Goats In District Killa Saifullah, Balochistan

by Wseem Khan (2008-VA-214) | Dr. Muhammad Lateef | Dr. Saadullah Jan | Dr. Haroon Akbar | Dr. Muhammad Avais.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: With the passage of each day, the parasites are becoming more and more drug resistant thus reducing the options for their treatment. There is a need to explore herbal products having anthelmintic activity. The aim of this study was be to evaluate therapeutic efficacy of Euphorbia plant against gastrointestinal nematodes of goats. It is documented that Euphorbia plant extracts have efficacy against GIT nematodes in goats. (CP) and (CME) of the plants were used to evaluate the effect of the plant on GIT nematode in goats. Eighty goats positive for GIT nematodes were selected for GIT nematodes in vivo study of the plant and Albendazole. Goats were divided into 8 groups and each group containing 10 goats. Animals in group A were positive Control Untreated Group, in group B that is B1, B2 and B3 were treated with 1g/kg b.wt. CP of Euphorbia 2g/kg b.wt. CP of Euphorbia and 3g/kg b.wt. CP of Euphorbia respectively. Animals in group C that is C1, C2 and C3 were treated with CME of Euphorbia. At the equivalent dose rate of 1g/kg b.wt CP, CME of Euphorbia at the equivalent dose rate of 2g/kg b.wt CP and CME of Euphorbia at the equivalent dose rate of 3g/kg b.wt CP. Group D were treated with Albendazole at recommended dose rate of 3.8mg/kg body weight. Animals were treated on day zero with crude methyl extract of Euphorbia plant, crude powder of Euphorbia plant, and Albendazole. Sampling was done on day 0 pre-treatment 7, 14 and 21 post-treatment to determine eggs per gram (EPG) of faeces. Data was tabulated and subjected to SPSS and one way ANOVA was performed to find out treatment differences. Potential anthelmintic efficacy of Euphorbia plant against GIT nematodes of goats was a good herbal alternate for treatment of GIT nematode worm infections. Albendazole gave the best results in the in-vivo drug trial. The efficacy of the drug was 99.26%. This efficacy of 99.26% showed by animals in group D was highest in all treated groups. The effect of Albendazole at 21st day post treatment was significantly higher (P<0.05) than other groups treated with Euphorbia plant preparations. Crude powder of Euphorbia was highly effective as (P < 0.05) compared to the untreated control group of animals. The crude powder showed dose and time dependent decline in EPG of the nematodes infested animals. Highest efficacy was shown by the dose rate of 3g/kg body weight monitored for 21 days post treatment. The efficacy of crude powder 1g/kg body weight, 2g/kg body weight and 3g/kg body weight was 17.86%, 20.34% and 36.24% respectively. Highest efficacy was shown by crude methyl extract of the plant given orally at the dose rate equivalent to 3g/kg body weight of the animal. The efficacy of the CME of plant was 53.96% at 21st day post treatment. The old-fashioned remedy used for the cure of helminthes Euphrbia an herbal medicinal plant exhibit the anthelmintic activity against gastrointestinal nematodes. It may be suggested that the herbal plants used traditionally as curative agent should be tested out extensively for their efficacy against GIT nematodes. Further studies are required to be carried out for the Euphorbia plant and identification of active principles of the plant and toxicity studies. Availability: Items available for loan: UVAS Library [Call number: 2769-T] (1).

Place hold Add to cart

Implemented and Maintained by UVAS Library.
For any Suggestions/Query Contact to library or Email:rehana.kousar@uvas.edu.pk Phone:+91 99239068
Website/OPAC best viewed in Mozilla Browser in 1366X768 Resolution.