2.
Effects Of Clopidol And Lasalocid (Avatec) (Coccidiostats) On The Immunity Of Broiler Chicks Vaccinated
by Umer Farooq, M | Dr. Syed Ata-ur-Rehman Rizvi | Dr. Khalid | Dr. Muhammad Akram Munir | Faculty of Veterinary Sciences.
Material type: ; Format:
print
Publisher: 1994Dissertation note: The birds that received Avatec at recommended dosage levels had higher body weight than the Clopidol medicated, Cyclophosphamide treated or untreated control birds.
Both Avatec and Clopidol treatments did not adversely affect the weights of bursa of Fabricius, spleen, thymus and liver of birds. Cyclophosphamide treatment of birds in early life resulted in.bursal atrophy and slight depression of splenic weight gain.
Avatec and Clopidol were immuno-stimulants and birds eating medicated rations had higher antibody titres as compared to control birds. The NDV vaccinated birds on Avatec and Clopidol medicated rations and those on non-medicated rations resisted challenge with a virulent ND virus, while the non-vaccinated birds of any treatment group and vaccine free control could not withstand this challenge.
Conclusions
This study indicated that Clopidol and Avatec, when used at recommended dosage levels (25 gm of Premix/50 kg of feed and 6.25 gm of pure drugl5O kg of feed respectively) did not interfere with the development of birds; did not have any adverse effects on weights of lymphoid organs such as bursa of Fabricius, spleen, thymus, liver; did not interfere with the development of humoral immunity in vaccinated birds. Their medication in feed rather produced beneficial effects on serum, weight gain and antibody production. The injection of Cyclophosphamide resulted in lower body weights, destruction of the bursa of Fabricius, poor antibody response of birds to vaccination against NDV, and very high post-challenge mortality.
The weight gain studies indicated that vaccinated and non- vaccinated birds on Clopidol and Avatec medicated feeds had non- significantly higher body weights that those on non-medicated ration at 56 days of age. Avatec at recommended dosage level, had more beneficial effects on the body weights than the Clopidol. These studies further indicated that vaccinated birds kept on Avatec medicated feed had significantly higher serum antibody titres on day 56 than the vaccinated non-medicated control birds.
From the results of this study it is concluded that Avatec and Clopidol are not immuno-suppressive drugs when used at recommended dosage levels. They rather have beneficial effects on growth performance and immune response of birds. However, there is a need for further investigations.
Availability: Items available for loan: UVAS Library [Call number: 0459,T] (1).
3.
Characterization And Antibiotic Sensitivity Of Pasteurella Multocida Isolates From The Field Cases Of Haemorrhagic Septicaemia In Buffloes Of Punjab
by Puran Das | Dr. Muhammed Amin Sheikh | Dr. Syed Ata-Ur-Rehman Rizvi | Faculty of Veterinary Sciences.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 1996Dissertation note: The research project accomplished was primarily concerned with the isolation and characterization of P. multocida strains involved in field outbreaks of HS in buffaloes of Punjab Province of Pakistan. In addition, isolates were also examined for their sensitivity to various antibiotics and suipha drugs. Isolation attempts, made both on blood samples of live diseased animals and long bones of the dead/slaughtered animals, yielded 10 strains of the organism, solely from the long bones.
All the strains of P. inultocida isolated were uniform in their sugar fermentation and other biochemical reactions, giving a positive reaction for glucose, fructose, mannose, mannitol, sucrose, sorbitol and xylose, producing acid only and no gas. Like wise a positive reaction was also recorded for catalase, oxidase, indole production, nitrate reduction and H2S production tests. All the strains were however, unable to ferment arabinose, inositol, lactose, maltose, salicin, dulcitol and raffinose sugars and were negative for methyl red, voges proskauer, urease activity and gelatin liquefaction tests.
All the isolates of P. multocida were serologically identified as Roberts type I. All the isolates proved highly pathogenic both to rabbits and mice alike.
The antibiotic sensitivity results against 10 field strains and one reference strain of P. inultocida showed amoxicillin to be the most effective antibiotic. The rest of the antibiotics, placed in accordance with their effectivity, in descending order are ampicillin, chloramphenicol, norfloxicin, kanamycin, gentamycin, oxytetracycline and sulphamethaxazole + trimethoprim.
None of the antibiotics except amoxicillin, was able to display equal effectivity against all the 11 strains of P. multocida examined.
Availability: Items available for loan: UVAS Library [Call number: 0486,T] (1).
