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1. Incidence And Therapeutic Trails Of Sub Clinical Ketosis In Cows In And Around Lahore

by Muhammad Ramzan | Dr. Jawaria Ali Khan | Prof. Dr.. Muhammad sarwar Khan.

Material type: book Book; Format: print Publisher: 2011Dissertation note: Subclinical ketosis is preclinical stage of ketosis. The peak incidence of subclinical ketosis occurs during the fourth week of lactation. There are indications that cows with the highest milk yield directly after calving are at greatest risk for developing ketosis. Subclinical ketosis causes delayed reproductive functions, increased intervals from calving to first and last service, and an increased frequency of ovarian cysts. The study was designed to diagnose the Subclinical ketosis on the basis of Ross Rothra's method. This method was easy to conduct and can be able to perform at the farm. The purple color indicated the presence of ketone bodies in the sample. After diagnosis the treatment trails was done on three different treatment methods comprises of Dextrose, Dexamethasone and by increasing the diet. Total 200 cow were studied for the diagnosis of subclinical Ketosis. Total positive samples of subclinical ketosis were 62 and the overall Incidence of Subclinical Ketosis in was 31 % and in sheikhupura and Raiwind areas it was 35% & 27 respectively. The results indicates that the use of dexamethasone was very effective and it cured 84%,dextrose cured 64% ,and by the diet it was 25%.Although, dexamethasone was very effective but it also reduced the milk production in very next day after the administration of drug while, the dextrose shows no any reduction in milk production. The animals who received only green fodder as ration showed very positive results for subclinical ketosis while, the animals who received a concentrated diet with green fodder they showed very little presence of subclinical ketosis. Prevention of subclinical ketosis can be done by providing extra ration to pregnant animals and during pregnancy give them pregnancy allowance and by effective managemental practices the effects of subclinical ketosis can be minimized. Availability: Items available for loan: UVAS Library [Call number: 1369,T] (1).

2. Prevalence And Chemotherapy Of Trichuriasis (Whi Worm) In Dogs.

by Muhammad Ramzan | Dr. Muhammad Hassan Saleem | Prof. DR. Muhammad Sarwar Khan.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2012Dissertation note: In developing countries like Pakistan the trend of establishment of kennel clubs are increasing day by day. While the population of dogs increase the strong practice of vaccination and deworming increase as well. Parasitism is a major problem in our country. It causes great economic losses. The genus Trichiuris is one of the important nematode which affect the dogs. Therefore a study of genus Trichiuris was conducted in month of March to May, 2012. For this purpose 300 hundreds dogs of different breeds of dogs were selected for investigation of Trichiuris vulpis. Samples were collected and brought to the Clinical laboratory of Department of Clinical Medicine and Surgery in University of Veterinary and Animal Sciences Lahore. In laboratory positive samples for Trichiuris vulpis were recorded. The overall prevalence of Trichiuris vulpis was found to be 20% .The dogs positive for Trichiuris vulpis were divided into three groups A, B and C having 10 dogs in each group. Group A and B were treated with pyrantal pamoate and fenbendazole respectively. While the group C was positive control. The efficacy of both the drugs were measured by the decrease in egg per gram of faeces after medication. The egg counts were made at day zero, 7th and 14th. The efficacy of pyrantal pamoat recorded on day 7th and 14th was 95.30 and 98.61% respectively while the efficacy of fenbendazole recorded on day 7th and 14th was 90.76 and 93.84% respectively. The obtained data was tabulated and analyzed by ANOVA. Statistical analysis showed that there was significant (p<0.05) difference between the efficacy of payrental pamoate and fenbendazole after treatment of infected dogs at day 7th and 14th. This analysis showed that payrantal pamoate is significantly superior in its efficacy than fenbedazole. The purpose of the study for prevalence and estimation of comparative efficacy of two drugs against Trichiuriasis in dogs was accomplished. Availability: Items available for loan: UVAS Library [Call number: 1490,T] (1).

3. Toxicity Problems Associated With Declofenac In Avaian Species And Its Substitute

by Muhammad Ramzan | Dr. Haji Ahmad Hashmi | Dr. Zafar Iqbal Chaudhry | Prof. Dr. Talat.

Material type: book Book; Format: print ; Literary form: drama Publisher: 2010Dissertation note: A catastrophic decline in vulture populations was first observed in 1996-97 in Keoladeo National Park, Bharatpur, Rajasthan, India. Later, similar situations were reported in many south Asian countries including Pakistan, Nepal and Bangladesh. Now, the International Union for the Conservation of Nature (IUCN) has listed three vulture species i.e. Gyps bengalensis, Gyps indicus and Gyps tenuirostris as 'critically endangered'. Vultures are natural scavengers and play a key role in keeping the environment clean by consuming carcasses of dead livestock and wildlife. The unconsumed animal carcasses pose a serious threat to both human and animal health because decaying animal carcasses may contaminate groundwater and become a potential source of diseases such as tuberculosis and anthrax for humans and other animals. Also, due to the declines in vulture populations, a rise in the numbers of other scavengers like dogs has been observed. Therefore, the risk of dog bite and transmission of dangerous diseases, including rabies, has also increased. Furthermore, vultures play a vital role in the disposal of human corpses of the followers of the Parsi religion because they place their dead bodies before vultures for disposal rather burial beneath the earth. In the South Asian region, different communities have different attitudes toward the use of meat and its products. For example, Muslims do not use meat of dead animals, whereas Hindus abstain from cow's meat altogether because of religious bindings. For many centuries, the disposal of such meat has been done by vultures. The vulture population decline issue was investigated by researchers with the support of various international organizations dedicated to bird conservation in collaboration with regional ornithological societies. Scientists looked into the problem from different angles and considered a variety of reasons of this decline. These included food shortages, losses of habitat, persecution, human disturbances, infectious agents, environmental contaminants, intentional poisoning, and accidental poisoning through food or water. Initially, the outbreak of some infectious disease and/or poisoning appeared to be the most plausible basis of this crisis. Recent studies have ruled out presence of a widespread infection and have focused on some form of poisoning. Now, it is believed that diclofenac, a veterinary drug, was responsible for the huge fatalities in vultures, in part because the onset of the crisis was coincident with the introduction of this drug in veterinary practice. Diclofenac belongs to a class of drugs called, non-steroidal anti-inflammatory drugs (NSAIDs). Diclofenac served as an effective analgesic (pain killer), antipyretic (reduces fever), and anti-inflammatory (reduces swelling) drug. Initially, this drug was used in human beings for various indications such as arthritis. The use of diclofenac was started in domestic animals in the region a decade ago. It was reported that the presence of diclofenac in the bodies of dead animals that had been treated with this drug shortly before death was harming the vultures feeding on contaminated carcasses (Oaks et al., 2004; Shultz et al., 2004; Swan et al., 2005). The Department of Pharmacology and Toxicology, at the University of Veterinary and Animal Sciences, Lahore, has been given the task to investigate this problem. A series of experiments was conducted to study the likely causes of this problem and, if possible, find its solution by developing safer and efficacious alternatives to diclofenac for the treatment of animals. For this purpose, a chicken experimental model was developed to study the toxicity of diclofenac and other NSAIDs. These studies have shown that diclofenac produced similar toxic effects and mortalities in broiler chickens as had been reported from studies of diclofenac-poisoned vultures. Later on, therapeutic efficacy studies of safer alternative NSAIDs of diclofenac were conducted in horses, buffaloes. On the basis of these current studies, it was concluded that diclofenac was toxic to chickens and no significant difference was present in the death rates in bird groups treated with toxic doses of diclofenac via oral and intramuscular routes. Sodium and potassium salts of diclofenac caused comparable casualties in broiler chickens (unpublished study). A number of other NSAIDs were screened for their toxicity profile using the chicken model. This study showed that phenylbutazone, dipyrone, meloxicam, piroxicam and ketoprofen were comparatively safer than diclofenac. However, phenylbutazone and dipyrone may not be appropriate alternatives for diclofenac in food-producing animals because they are known to cause a condition called agranulocytosis in human and animals. Agranulocytosis involves marked reductions in numbers of white blood cells that are responsible for maintaining the body's immunity against various diseases. To evaluate the efficacy of safer drugs, fever was induced in buffalo calves with Escherichia coli endotoxin (lipopolysaccharide), and the animals were then treated them with ketoprofen, meloxicam orpiroxicam. Although, all three drugs were effective in lowering body temperature, ketoprofen was the most efficient. In another experiment, these drugs were used in the treatment of lameness in horses, and it was concluded that meloxicam was more effective followed by piroxicam and ketoprofen for the treatment of this particular problem. Based on these observations, it is concluded that ketoprofen, meloxicam and piroxicam may prove quite safe drugs for the scavenging birds and may be used as safe alternatives to diclofenac in veterinary practice. It has been observed during this study that ketoprofen, piroxicam, and meloxicam are less toxic for broiler chickens and may prove better alternates to be used in place of diclofenac in animals. The use of these NSAIDs may be less toxic for scavenger birds. The commercial preparations of ketoprofen and meloxicam for veterinary use are available at least in two south-east Asian countries i.e. Pakistan and India. The prices of these NSAIDs are comparable with those of the veterinary preparations of diclofenac which were previously available in the region. On the basis of results of this study it is concluded that ketoprofen, piroxicam, and meloxicam are effective NSAIDs in domestic animals, hence may replace diclofenac in veterinary practice. Availability: Items available for loan: UVAS Library [Call number: 1784,T] (1).

4. Molecular Characterization Of Brucella Abortus Strains In Bovines

by Muhammad Ramzan | Dr. Raheela Akhtar | Prof. Dr. Aneela | Prof. Dr. Asim Aslam.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2169,T] (1).

5. Filah e Milat

by Muhammad Ramzan Sahid.

Edition: 1stMaterial type: book Book; Format: print ; Literary form: not fiction Publisher: Lahore: Al-Madina ndAvailability: Items available for loan: UVAS Library [Call number: 297.1 Ramzan 22197 1st nd Islam] (1).

6. Epidemiology And Control Of Gastro-Intestinal Nematodes Of Large Ruminants In Balochistan

by Muhammad Ramzan (2009-VA-653) | Dr. Nisar Ahmad | Prof. Dr. Muhammad Azam Kakar | Prof. Dr. Kamran Ashraf | Prof. Dr. Aneela Khurram.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: The main area of research in this study was to assess the prevalence, hematological aspects of Bovine nematodiasis. Three main experiments were conducted to highlight the objectives of the present research study. The first experiment was conducted to find out the prevalence of large ruminants major nematodes for one year. For this purpose buffalo and cattle of either sexes and between < 1 year to > 2 years of age were selected from two sites i.e., Quetta and Qilla Abdullah. Fecal analysis of these cattle and buffalo showed overall higher (33.99%) nematodes prevalence recorded in buffalo in Quetta, (27.99%) in cattle at Qilla Abdullah followed by in cattle at Quetta (26.66%). Five nematode infection was recorded in all two experimental sites with higher prevalence of Haemonchus contortus in buffalo at Quetta and Ostertgia ostertagi in cattle at Quetta and Qilla Abdullah. The buffalo and cattle of < 1 year presented higher nematodes prevalence than 1-2 years and > 2 years. The female buffalo and cattle were infected with nematodes prevalence higher than male animals. These five nematodes were prevalent almost throughout the year, however a peak infection was recorded during August and September in cattle and October in buffalo. The high temperature, rainfall and humidity during these months may be predisposing factor of higher prevalence. Mostly the level of nematodes infection was low(< 800 EPG) and did not seriously impaired the buffalo and cattle productivity. Second experiment on assessing the comparative efficacy of anthelmintics (Levamisole, Oxafendazole and Ivermectin) against cattle and buffalo nematodes were conducted at Govt and private farms. The results showed that Ivermectin than Oxfendazole were found effective against cattle and buffalo nematodes. The higher (89-100%) reduction of EPG were recorded in cattle and 87 buffalo calves treated with Ivermectin followed by Oxfendazole (86-100%), Levmisole (88- 100%). Third experiment was conducted to determine the hematological values in healthy and nematodes infected animals. Different hematological parameters i.e., TEC, TLC, Hb estimation, were determined. The results showed that overall low Hemoglobin estimation and RBC were recorded in nematodes infected animals than healthy, while higher WBC were recorded in nematodes infected animals than healthy. The Lymphocytes and Neutrophil and Monocytes were higher in some nematodes and lower in other, while higher mean Eosinophil counts was recorded in all nematodes infected animals than healthy animals. Availability: Items available for loan: UVAS Library [Call number: 2730-T] (1).



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