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1. A Study Of Risk Factors And Chemotherapy Of Patent Stongyloides Westeri Infection In Foals In Lahore

by Saima Batool (2015-VA-837) | Dr. Jawaria Ali khan | Dr. Muhammad Avais | Dr. Arfan Ahmed.

Material type: book Book; Literary form: not fiction Publisher: 2017Dissertation note: Data is available on prevalenc of strongyloideswesteri in foals which cause diarrhea and its allopathic treatment is also available but there is no data available on herbal treatment of s. westeri and best protocol of allopathic drugs. So the purpose of the study is to study the incidence of S. westeri in foals. The risk factors associated with S. westeri and to develop the best treatment protocol for S. Westeri. The hypothesis of this study is; Identification of risk factors that was associated with S. westeri and efficacy of Allopathic verse herbal drugs was determined against S. westeri. Fecal samples were collected from foals. Gloves were lubricated with lubricating material before the sampling. Sample will be collected directly from rectum of the foals. The fecal material was collected in the properly labeled plastic jar. The samples were processed and examined in the Medicine Laboratory, University of Veterinary and Animal Sciences Lahore. Direct smear examination was carried out for the of S. westerieggs under microscope. For quantitative analysis, Mac Master Technique was used. The positive foals were divided into three groups A, B and C to check the efficacy of drugs on S. westeri. These groups were going through to chemotherapeutic trials with different groups of medicines including herbal and allopathic. Herbal medicine was Ginger (zingiberofficinale) and allopathic were oxibendazoleand ivermectin. Milk samples were also collected from newly parturated mares then evaluation and biometery of larvae was also done just to study the risk factors that transfer larvae from dam to foal through colostrum. Comparison and Identification of eggs and larvae in milk along with treatment effect were analyzed by Chi Square method using the SPSS software 22 version. The data obtained from this study revealed that:  The main source of S. westeri infection was milk of dams. The larva of S. westeri passed through the dam’s milk to foals.  The prevalence of S. westeri was strongly associated with the risk factor such age, colostrum intake, species, breed, dite, environment, water supply and deworming treatments.  Vaccination had no effect on prevalence of S. westeri.  Allopathic drugs are more efficient against S. westeri infection in foals as compared the herbal drugs.  The efficacy of Ivermectin was more as compared to Oxibendazole. Availability: Items available for loan: UVAS Library [Call number: 2817-T] (1).

2. A Study Of Risk Factors And Chemotherapy Of Patent Stongyloides Westeri Infection In Foals In Lahore

by Saima Batool (2015-VA-837) | Dr. Jawaria Ali khan | Dr. Muhammad Avais | Dr. Arfan Ahmed.

Material type: book Book Publisher: 2017Dissertation note: Data is available on prevalenc of strongyloideswesteri in foals which cause diarrhea and its allopathic treatment is also available but there is no data available on herbal treatment of s. westeri and best protocol of allopathic drugs. So the purpose of the study is to study the incidence of S. westeri in foals. The risk factors associated with S. westeri and to develop the best treatment protocol for S. Westeri. The hypothesis of this study is; Identification of risk factors that was associated with S. westeri and efficacy of Allopathic verse herbal drugs was determined against S. westeri. Fecal samples were collected from foals. Gloves were lubricated with lubricating material before the sampling. Sample will be collected directly from rectum of the foals. The fecal material was collected in the properly labeled plastic jar. The samples were processed and examined in the Medicine Laboratory, University of Veterinary and Animal Sciences Lahore. Direct smear examination was carried out for the of S. westerieggs under microscope. For quantitative analysis, Mac Master Technique was used. The positive foals were divided into three groups A, B and C to check the efficacy of drugs on S. westeri. These groups were going through to chemotherapeutic trials with different groups of medicines including herbal and allopathic. Herbal medicine was Ginger (zingiberofficinale) and allopathic were oxibendazoleand ivermectin. Milk samples were also collected from newly parturated mares then evaluation and biometery of larvae was also done just to study the risk factors that transfer larvae from dam to foal through colostrum. Comparison and Identification of eggs and larvae in milk along with treatment effect were analyzed by Chi Square method using the SPSS software 22 version. The data obtained from this study revealed that:  The main source of S. westeri infection was milk of dams. The larva of S. westeri passed through the dam’s milk to foals.  The prevalence of S. westeri was strongly associated with the risk factor such age, colostrum intake, species, breed, dite, environment, water supply and deworming treatments.  Vaccination had no effect on prevalence of S. westeri.  Allopathic drugs are more efficient against S. westeri infection in foals as compared the herbal drugs.  The efficacy of Ivermectin was more as compared to Oxibendazole Availability: No items available

3. Genetic Variation In The Promoter Region Of Pro Inflammatory Cytokine Tnf-Α Among Hiv Infected People In Lahore

by Shahid Nawaz (2015-VA-437) | Prof. Dr. Tahir Yaqub | Dr. Arfan Ahmed | Dr. Asif Nadeem.

Material type: book Book Publisher: 2017Dissertation note: Despite of the fact that HIV is one of the most studied virus of the present time, so far there is no legitimate cure for the treatment of HIV AIDS, and in most cases AIDS is often fatal. Immune response has always been vital to cope with any disease. In context of immune response TNF-α is mainly released by the macrophages as a pro inflammatory cytokine. Studies have shown that HIV infected persons have higher concentration of TNF-α released. A particular single nucleotide polymorphism (SNP) is observed at -308 position of the promoter region of TNF- α gene due to which TNF is categorized into TNF1 and TNF2 allele. TNF2 allele is associated with higher concentration of TNF- α which in turn is associated with HIV infection. In order to know the particular association in the population of Lahore we designed this study. The hypothesis was that SNP at -308 position of the TNF- α may be associated with HIV infection. Methodology was designed as follows: 15 HIV positive samples and 15 HIV negative samples were taken and categorized into group A and B respectively. Whole Blood samples were taken from the patients and subjected to DNA extraction using commercially available kit (Favorgen blood DNA mini extraction kit). Specific primers were used to amplify the particular region (-308) of TNF- α through PCR. A small amount of PCR products were subjected to restriction enzyme Ncol. Sequencing was done and the results were analyzed using specific bioinformatics tools such as NCBI. -308 region of the TNF-alpha was analyzed for the SNPs (TNF1 and TNF2). Collected data was analyzed through SPSS for association studies. Outcome could be as follows: The study is designed to identify SNPs at -308 position of the promoter region of TNF-α gene. It will enable us to understand the possible association between TNF- α and HIV AIDS. It will be the first ever study regarding TNF- α and AIDS in Pakistan. Availability: Items available for loan: UVAS Library [Call number: 2833-T] (1).



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