1.
Comparative Efficacy Of Polypropylene And Polyester Mesh For The Repair Of Abdominal Wall Defect In Pigeons
by Muhammad Naveed Ali (2007-VA-114) | Dr. Hamad Bin Rashid | Prof. Dr. Muhammad Arif Khan | Dr. Asim Khalid Mahmood.
Material type: ; Literary form:
not fiction
Publisher: 2016Dissertation note: Polypropylene is a widely used biomaterial for the treatment of ventral abdominal wall hernias. It exhibit pain, prominent inflammatory response and foreign body reaction. Polyester (Polyethylene terephthalate) is hydrophilic material works with body’s natural systems to improve tissue integration while reducing negative foreign material response. Polyester offers extremely lower pain intensity and less foreign body reaction.
The purpose of designated research was to compare the efficacy of polypropylene and polyester meshes for the treatment of abdominal defect. Both are non-absorbable meshes. Polypropylene mesh is available in Pakistan with the trade name of Prolene® (Ethicon,Johnson & Johnson, USA). Polyester mesh is not available inPakistan and was acquired from Al Zahrawi Medical, a local healthcare company in Dubai, United Arab Emirates. Polyester mesh is available with brandname of (Parietex®, Covidien, France).
The experimental study was conducted on 16 (sixteen) healthy pigeons presented for massive abdominal defect repair. All birds were thoroughly examined to rule out any other anomaly before study. The birds were allocated into two different groups, viz. Group A and Group B with 8 birds in each group respectively. All treatments were administered intramuscularly using 1 ml insulin syringe. The Polypropylene mesh (Prolene®, Ethicon) was used for the treatment of abdominal repair for group A. The birds of group B was treated with Polyester mesh (Parietex®, Covidien). Ventral abdominal wall repair was performed in both groups using Polypropylene and Polyester mesh respectively. The surgery was performed at Surgery Section, Department of CMS, UVAS, Lahore for 3 months duration (including adaptation and postoperative period). Both meshes were compared on the basis of postoperative complications (wound healing, pain evaluation, hematoma, seroma and abscess formation), inflammatory responses and adhesion formation after application of mesh fixation.
During experiment, it was observed that polypropylene mesh resulted in a prominent pain sensation, persistent inflammatory reaction, proliferating fibroblast, more granulating tissue, macrophages appearance, increased connective tissue thickness and proliferating collagen fibre. It was observed that Polyester mesh resulted in less pain sensation, no foreign body reaction, no neutrophil appearance and rare granulating tissue. Polyester mesh showed remarkable advantages over polypropylene mesh in terms lower pain level, reduced size seroma and extremely less scar tissue formation.
Based upon all the findings it was concluded that polyester mesh is safer and more effective in terms of post-operative complications and outcomes.
Availability: Items available for loan: UVAS Library [Call number: 2495-T] (1).
2.
Comparative Efficacy Of Prazequantel, Niclosamide And Pumpkin Seeds Against Dipylidium Caninum In Dogs
by Ayesha Arif (2015-VA-22) | Dr. Asim Khalid Mahmood | Dr. Uzma Farid Durrani.
Material type: Publisher: 2017Dissertation note: Dypilidium caninum is a hermaphrodite Cestode (flatworm) consisting of a scolex, neck region and repeating segments and lacking mouth, intestine and body cavity. It has an indirect life cycle. The adult form of the tapeworm is acquired by definitive host through the ingestion of intermediate host which contains the larval metacestode stage. The major aftermath of such infections is the shedding of eggs and proglottids. It is a serious economic and zoonotic health threat. Life-threatening disease in humans, dogs and cats can be resulted by the presence of the of tapeworms immature (metacestode) stages occurring in various tissues.
The dogs clinically suspected for Dipylidium caninum and dogs having flea infestation were subjected to fecal analysis/EPG for D. caninum. Thirty dogs positive for D. caninum were divided randomly into 3 groups of 10 i.e. A, B and C. The dogs in group A were treated with praziquantel at the dose rate of 5 mg/kg orally while the animal in group B were given niclosmiode at the dose rate of 100 mg/kg per oral. The members in the group C were given pumpkin seeds powder at the dose rate of 5 gram orally.
The fecal samples from dogs in each group were collected at day 0 (pretreatment) and then at day 7, 14 and 21 (post treatment). Standard fecal flotation technique was performed for identification of Dipylidium caninum eggs using saturated salt solution. McMaster counting chamber was used for the counting of eggs.
The study results were analyzed using one way ANOVA on SPSS version 17.0. The results showed that in a post-treatment sampling of group A, the EPG count was significantly
Summary
37
reduced. Group B smplings also showed a good reduction in EPG but with the second dose whereas group C results were unsatisfactory.
On the basis of the results of this study it was concluded that Praziquantel is much more effective against Dypilidium caninum as compared to Niclosamide and pumpkin seeds, but high cost and no availability in Pakistan makes it difficult to be effectively used against Dypilidium caninum while niclosaamide is easily available and low in price. Niclosamide is effective against Dypilidium caninum but not up to the extent of praziquantel. Pumpkin seeds have poor effect on Dypilidium caninum Availability: Items available for loan: UVAS Library [Call number: 2856-T] (1).
3.
Comparative Efficacy Of Prazequantel, Niclosamide And Pumpkin Seeds Against Dipylidium Caninum In Dogs
by Ayesha Arif (2015-VA-22) | Dr. Asim Khalid Mahmood | Dr. Uzma Farid Durrani | Prof. Dr. Waseem Shehzad.
Material type: Publisher: 2017Dissertation note: Dypilidium caninum is a hermaphrodite Cestode (flatworm) consisting of a scolex, neck region and repeating segments and lacking mouth, intestine and body cavity. It has an indirect life cycle. The adult form of the tapeworm is acquired by definitive host through the ingestion of intermediate host which contains the larval metacestode stage. The major aftermath of such infections is the shedding of eggs and proglottids. It is a serious economic and zoonotic health threat. Life-threatening disease in humans, dogs and cats can be resulted by the presence of the of tapeworms immature (metacestode) stages occurring in various tissues.
The dogs clinically suspected for Dipylidium caninum and dogs having flea infestation were subjected to fecal analysis/EPG for D. caninum. Thirty dogs positive for D. caninum were divided randomly into 3 groups of 10 i.e. A, B and C. The dogs in group A were treated with praziquantel at the dose rate of 5 mg/kg orally while the animal in group B were given niclosmiode at the dose rate of 100 mg/kg per oral. The members in the group C were given pumpkin seeds powder at the dose rate of 5 gram orally.
The fecal samples from dogs in each group were collected at day 0 (pretreatment) and then at day 7, 14 and 21 (post treatment). Standard fecal flotation technique was performed for identification of Dipylidium caninum eggs using saturated salt solution. McMaster counting chamber was used for the counting of eggs.
The study results were analyzed using one way ANOVA on SPSS version 17.0. The results showed that in a post-treatment sampling of group A, the EPG count was significantly
Summary
37
reduced. Group B smplings also showed a good reduction in EPG but with the second dose whereas group C results were unsatisfactory.
On the basis of the results of this study it was concluded that Praziquantel is much more effective against Dypilidium caninum as compared to Niclosamide and pumpkin seeds, but high cost and no availability in Pakistan makes it difficult to be effectively used against Dypilidium caninum while niclosaamide is easily available and low in price. Niclosamide is effective against Dypilidium caninum but not up to the extent of praziquantel. Pumpkin seeds have poor effect on Dypilidium caninum Availability: No items available
