Prevalence And Chemotherapy Of Coccidiosis In Sheep And Goats And Its Effect On Certain Blood Parameters
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Publisher: 1995 Dissertation note: This project was designed to find out the prevalance and chemotherapy of coccidiosis in sheep and goats and its effect on certain blood parameters like Haemoglobin, TLC, DLC, Glucose,and Total Serum Protein.
Two drugs namely suiphadimidine and suiphaqunoxaline were used in this research project. For this purpose 60 animals(i.e sheep and goats) were taken and divided into 3 groups(A,B and C) containing 20 animals each(i.e 10 sheep and 10 goats). Group A was again subdivided into two subgroups Ag & As containing 10 animals each(i.e 10 goats and 10 sheeps) were treated with sulphadimidine.Group B was again subdivided into two subgroups Bg & Bs containing 10 animals each(i.e 10 goats and 10 sheeps) were treated with suiphaquinoxaline. Group C was again subdivided into two subgroups Cg & Cs containing 10 animals each (i.e 10 goats and 10 sheeps) were kept as infected non.medicated control.
The efficacy of drugs were determined on the reduction of OPG in faeces.
From the results it is find out that the average OPG on zero day of medication in groups i.e Ag,As & Bg,Bs were 75100, 72200, 60800 & 67200 respectively.The average reduction of OPG on 10th day of medication in groups i.e Ag,As & Bg,Bs were 300,340,120 & 280 respectively.The OPG of control groups were increased on the subsequent days.
The average Haemoglobin on zero day of medication in groups Ag,As,& Bg,Bs were 6.53,8.02,6. 89 & 7.93 respectively The average Haemoglobin on lOtti day of medication in groups Ag,As,Bg,Ss were 8.628.80, 9.44 & 8.78 respectively.The Haemglobin of the control groups were decreased on subsequent days. Average TLC on zero day of medication in groups Ag,As,Bg,Bs were 16.50 ,16.50 & 15.50,19.50.Average TLC on 10th day of medication in groups Ag,As & Bg,Bs were 14.50,12.90 & 13.60,13.50 respectively.The TLC of control groups were increased on the subsequent days.Average DLC on zero day of medication in groups Ag was 49.40,68.00,7.00 11.10 & 17.50 in group Bg was 51.20 ,70.30,6.90, 12.20 & 19.40 in group As was 50.20,70.20,8.00,12.00 & 18.50 in group Bs was 22.214.171.124,6.10,17.20 & 18.40 .Average DLC on 10th day of medication in groups Ag was 48.40,67.00,7.00 11.10 & 17.50 in group Bg was 50.20 ,69.30,7.10,12.20 & 19.40.ln Group As was 49.40,69.10,8.00,12.00 & 18.50 in group Bs was 49.40,70.60,6.10,17.20,18.40.DLC of the control groups were incresed on the subsequent days. Average Blood Glucose on zero day of medication in groups Ag,As,Bg,Bs were 24.30, 31.30 & 29.30, 35.50 respectively.Average Blood Glucose on 10th day of medication in groups Ag,As,Bg,Bs were 37.00, 42.40, 42.80, 45.00. Blood glucose in control were decreased on the subsequent days. Average Total Serum protein on zero day of medication in groups Ag,As & Bg,Bs were 3.52,4.25,3.93,4.18. Average Total Serum protein on 10 th day of medication in groups Ag,As,Bg,Bs were 4.89,5.56 & 5.43,5.57 respectively.The total serum protein in control groups were decreased on the susequent days.
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Comparative Efficacy On Newly Introduced Antibacterial Drugs Against Experimentally Induced Escherichia Coli
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; Literary form:
Publisher: 1996 Dissertation note: Pakistan faces an acute shortage of animal protein which is acknowledged as a serious problem at national level. Since broilers are the fastest converters of crude protein into digestible high quality protein for human consumption. There is much need in the production of broilers for the said reason in Pakistan. The upgrading of poultry industry is suffered from huge losses caused by certain diseases of bacterial origin. Amongst bacterial diseases, Escherichia coli is the worst threat to poultry industry. Therefore, concrete and consistent effort was done in this project to control the Eschericia coli infection.
The present project was done to study the efficacy of different drugs on prevalent strains of E. coli isolated from broilers that were collected from Diagnostic Laboratory, office of the Project Director, Poultry Production, 16-Cooper Road, Lahore and various Farms in the vicinity of Lahore.
Six different antibacterial drugs which comprised of avitryl, advocin, plasmacolin, flumequine gentamicin and inoxyl were used to check the sensitivity of the isolates. In-vitro the sensitivity results was in this order avitryl, advocin, plasmacolin, gentamicin, flumeuine and inoxyl respectively. Avitryl emerged as best drug.
The pathogenicity of the isolated strains was tested in albino mice taken from V.R.I., Lahore. The confirmed pathogenic isolates of . coli were diluted upto 3x108 bacteria per 0.25 ml, this dilution ws made after doing total viable count and the dose was injected intra-peritoneally to five albino mice while 5 albino mice were kept as controls.
These six drugs were further tested for their efficiency in broilers against . coli infection. A total of two hundred and forty birds reared upto four weeks of age and then they were divided into eight groups, A, B, C, D, E, F, G and H, each having 30 birds. Group H was kept as non-infected and non- treated. While Group G was infected but not treated. The remaining groups A, B, C, D, E and F, 16 hours after infection were treated with avitryl, advocin, plasmacolin, flumequine, gentamicin and inoxyl for five days respectively. All the groups were kept under close observation and their mortality and feed efficiency was noted.
In group G maximum mortality was noted i.e. 57.14 while in the group A, B, C, D, E and F, the mortality recorded was 22.72, 30, 33.33, 40.90, 47.82 and 52.17 respectively.
Avitryl was proved to be the highest protection against coli infection and best in relation to F.C.R. by this experiment.
Availability: Items available for loan: UVAS Library [ Call number: 0492,T] (1).