1.
Estimation Of Heavy Metals In The Drinking Water Of Residential/Industrial Areas Of Lahore By Atomic Absorption
by Waheed Ahmad | Dr. Abu Saeed Hashmi | Dr. Sualeha | Miss Shagufta Saeed.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2010Dissertation note: Heavy metals are chemical elements with a specific gravity that is at least 5 times the specific gravity of water. The elements studied were mercury, lead, arsenic, cadmium and chromium. Heavy metals have no useful biological function in the body but might be highly toxic as they cause precipitation of proteins especially the enzymes. This investigation was therefore carried out to estimate concentration of these metals and their influence on biological system. For this purpose drinking water samples were collected in one litre polyethylene bottles adding 5 mL of concentrated HNO3 as preservative to adjust the PH<2.00 to maintain heavy metal concentrations during analysis. Samples were marked with unique numbers with dates for the study of Acid Extractable metals. Similarly samples were prepared and preserved for micro biological testing.
The metallic ions were estimated by Atomic absorption spectrophotometer of Perking Elmer Model A. Analyst; 2003 at recommended wavelengths for metal ion. Acetylene gas was used as fuel (at 8 psi) and air as an oxidizer.
Statistical analysis was done. The calibration curves were prepared separately for all the metals by running suitable concentrations of the standard solutions. It was evident that concentration of chromium, lead, mercury, arsenic and cadmium were high in several drinking water sources in Lahore. This problem is particularly alarming for ground water sources. Almost all water sources are contaminated with lead. According to WHO maximum acceptable limit 10 ppb ,8 water sources had mean chromium concentration in water samples above maximum acceptable limit of WHO (50 ppb), 94 water samples were contaminated with cadmium according to WHO maximum acceptable limit (10 ppb), 13 water sources had arsenic concentration above maximum acceptable limit according to WHO (50 ppb) where as 7 water samples were having concentration of arsenic less than minimum acceptable limit according to WHO (10 ppb) and only 5 water sources meet the criteria of WHO for concentration of mercury, the acceptable limit of 2 ppb.
Multitube Fermentation Technique/MPN Method as described by Mackie & McCartney was used for microbiological analysis i.e. Colifcrm bacteria. The results of this study revealed that both samples i.e. tap and ground water do not show conformity with the standards for safe portable water recommended by WHO. The most frequently encountered pathogen in this study was Escherichia Coli which was isolated more in ground water than tap water.
It is therefore concluded that by using Atomic Absorption Spectrophotometer concentration of heavy metals in water can be determined and thus on the bases of this work precautionary measures can be taken to prevent the health hazards of these toxic metals. Similarly microbiological analysis of drinking water has provided the evidence that most of the water sources are contaminated with microbes.
Availability: Items available for loan: UVAS Library [Call number: 1170,T] (1).
2.
Comparative Pharmacokinetics Of Carvediolol In Healty Male And Female Volunteers
by Alishba syed | Dr. Sualeha Riuffat | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2010Dissertation note: This study was designed to compare the pharmacokinetic parameters of Carvedilol in 6 healthy male and female volunteers. The study was conducted in six healthy male volunteers and six healthy female volunteers. Only those male volunteers were selected who were of age between 18-30 years, not suffering from any disease. Female volunteers were also between age of 18-30 years, who were not pregnant and not suffering from any disease. Written consent was taken from them and they were be informed about objectives of the study, frequency of blood sampling, and possible side effects of drug which they might face during the study. The male volunteers were considered as group A and healthy female volunteers were considered as group B. Both groups were treated with Carvedilol 12.5mg tablet per orally to each individual. 5m1 Blood samples were collected at 0, 0.25, 0.5, 1, 1.5. 2, 3, 4, 6, 8, 12 & 24 hr from vein through 5ml B.D syringe of 22guage needle after oral administration of Carvedilol. Plasma was separated by centrifugation at 5000 RPM and stored at -40°C till analysis. Carvedilol concentrations in plasma were measured by HPLC method. All pharmacokinetic parameters were calculated by entering plasma concentration-time data in software APO pharmacological analysis MW/PHARM version 3.02. Pharmacokinetic parameters of Carvedilol in healthy male volunteers and in healthy female volunteers were compared. Data was analyzed byapproprite statistical methods and no significant difference was found between AUC and Cmax. Absorption rate was highr in females as compared to males. AUC of Carvedilol was 0.076±0.021 µg.h/ml in healty male voluneteers and 0.197±0.105 µg.h/ml in healty female volunteers. The half life was 5.205±1.824 hours in healty male volunteers and 6.6768±1.328 hours in female volunteers. The Cmax was observed as 0.024±0.004 µg.h/ml in healty volunteers and 0.048±0.018 µg.h/ml in healty female volunteers.
Availability: Items available for loan: UVAS Library [Call number: 1180,T] (1).
3.
Bioequivalence Study Of Montelukast Tablets In Healthy Volunteets
by Sadia Amin | Dr. Sualeha Riffat | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Nature of contents: ; Literary form: Publisher: 2011Dissertation note: Objective of this bioequivalence study was to compare pharmacokinetic parameters
and to evaluate bioequivalence of two generic drug products. A multinational
company brand was compared with locally manufacture brand. It was a randomized,
single dose, two-period crossover study in which 12 volunteers were participated with
the age limit of 18-30yrs. These volunteers were selected according to different
inclusion and exclusion criteria and the study was conducted with one week washout
period. Each volunteer was one tablet of montelukast (reference or test) lOmg. 14
blood samples of 4-Sml collected at predefined time intervals i.e, 0, O.S, 1.0, 1.S, 2.0,
2.5, 3.0, 3.S, 4.0, 6.0, 8.0, 10, 12 and 24 hours .. Heparinized vacuette were used for
collection of blood samples. After sampling, blood samples were centrifuged
immediately to separate plasma and stored at -80°C till analyzed. Plasma montelukast
concentration was evaluated by using reverse phase - high performance liquid
chromatography (RP-HPLC) method. Potassium dihydrogen phosphate O.OSM at pH
3.5 with orthophosphoric acid in combination to acetonitrile (20:80) was used as
mobile phase. The wavelength of detector was set at 34Snm and flow rate was set to
2.0ml per min. Drug from plasma was extracted by de-proteinizing the plasma with
acetonitrile. 70 III injection volume was given to HPLC for analysis. For comparing
the pharmacokinetic parameters two compartment analysis was used and pair t-test was applied. Non compartmental analysis was used for evaluating pharmacokinetic
parameters to evaluate the both drugs were bioequivalent or not. 3 major parameters
of bioequivalence Cmax, AVC O-inf and AVC O-t were evaluated and they did not
show significant difference in between two formulations. Also the 90% confidence
interval values were within the limit. So, it was concluded that both the test and
reference drug were bioequivalent and test drug could be used interchangeably with
the reference drug.
Availability: Items available for loan: UVAS Library [Call number: 1311,T] (1).
4.
Bioequivalence Study Of Deferiprone In Healthy Volunteers
by Naila Waheed | Dr. Sualeha Riffat | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2011Dissertation note: The study was conducted with the aim of evaluating bioequivalence, relative
silability and efficacy of deferiprone manufactured locally (Ferinil, Global
aceutical, Pakistan) with a reference drug (Ferriprox, ApoPharma, Canada) in healthy
volunteers. It was a randomized crossover study enrolling 12 volunteers within age limit
g·55yrs and meeting the inclusion and exclusion criteria of the study, Each volunteer was
administered two tablets of deferiprone 500mg of both reference and test drug with a two-
washout period. Blood samples of about 5ml was collected at 0, 0.25, 0.5, 0.75, 1, 1.5, 5,4, 6, 8, 12 hour at predetermined time intervals and one sample was taken as control
giving first dose to volunteers. Heparinized vacuette was used for collection of blood
les. After sampling, blood samples was centrifuged at approximately 3000 rpm for 10
les and then stored at -80°C till analyzed. Plasma deferiprone levels were analyzed using
led High pressure liquid chromatography (HPLC) method. Pharmacokinetic parameters
calculated from plasma concentration time curve non-compartmentally and two-
artmental. After logarithmic transformation of data statistical comparisons of Cmax,
(0-1), AUC(o.oo) was calculated and appropriate statistical method was used for calculation. mean relative bioavailability was 104% and was proved to be bioavailable. The Cmax
(mean ±SD) for reference and test drug was 12.68 ± 4.91 and 14.41 ± 5.04 ug/ml,
ctively while average ± SD of AUCO-t and AUCO-inf of test and reference drug was 40.49
6,05 and 42.84 ± 18.47 ugh/ml and 38.63 ± 13.65 and 40.75 ± 14.17 ugh/ml. Average
(test/reference) of Cmax 90% CI was 0.9876-1.3125. Average ratio (test/reference) of
Co.190% CI was 0.9737-1.1150, and of AUCo-inf 90% CI was 0.9542-1.1343. Therefore both test and reference drug was fairly tolerated by volunteers and no adverse event was
detected. Hence, the average ratio of 90% confidence interval of AUCo-t and AUCO-inf was
0.9737-1.1150 and 0.9542-1.1343 that lie within the acceptable limit of (0.80 - 1.25) for
bioequivalence acceptance. Effectiveness of deferiprone depends on AUC instead of Cmax therefore the average ratio of 90% confidence interval of Cmax was 0.9876-1.3125 that lie
with the acceptable limit of WHO bioequivalence acceptance (0.75 - 1.33). ANOVA show
no significant variations among drug, period and sequence effect. Therefore, it was concluded
that Ferriprox was proved to be bioequivalent in healthy male Pakistani volunleers.
Availability: Items available for loan: UVAS Library [Call number: 1327,T] (1).
5.
Comparative Pharmacokinetics Of Silymarin In Healthy Male And Female Volunteers
by Farah Abid | Prof.Dr.Muhammad Ashraf | Dr. Mateen | Dr. Sualeha Riffat.
Material type: ; Format:
print
; Nature of contents: ; Literary form: Publisher: 2011Dissertation note: The study was designed to compare the pharmacokinetic parameters of Silymarin in 8
healthy male and 8 healthy female volunteers. Only those healthy volunteers were
selected who were of age between 18-45 years, not having any disease. Female's
volunteers were also of age of 18-45 years and also who were not pregnant and also not
suffering from any disease.
Written consent form were taken from the volunteer and they were thoroughly
inform about the study and objectives of study ,frequency of blood sampling, and any
other side effects linked to the drug which they might having during the study.
Volunteers were divided into two groups A and B respectively. Both groups
were given silymarin 200mg dose per oral to each individua1.5ml of blood samples were
drawn after different time interval .5 ,1,2,3,5,8 and 12 hr from the vein through 5ml BD
syringes of 22 gauge needle after oral administration of silymarin.
Plasma were separated by centrifugation at 5000 RPM and stored at -40 C till
analysis. Silymarin concentration in plasma was determined by using HPLC method. All
pharmacokinetics parameter were determined by entering the plasma concentration time
data in software APO pharmacological analysis .Then pharmacological parameters in
healthy male and healthy females were compared. Result showed that pharmacokinetic
parameters are significant & those parameters were AVC, Tmax, t1l2 & CI. This result
showed that there is a significant relationship between healthy male & female.
Availability: Items available for loan: UVAS Library [Call number: 1329,T] (1).
6.
Isolation And Characterization Of Collagen Type Ii From Poultry Trachea
by Sidra Ashraf | Dr. Abu Saeed Hashmi | Dr. Sualeha Riffat | Zahid Mushtaq.
Material type: ; Format:
print
Publisher: 2011Dissertation note: This project was designed to use poultry waste to isolate and characterize collagen type II
from its trachea. Collagen type II is being used along with condroitin sulfate and
glucosamine for the treatment of osteoarthritis and is also available as a neutraceutical
product in the market. For project purpose, trachea of slaughtered broiler birds were
collected from the market and after removing adhering tissue and debris, it was then
washed thoroughly first with distilled water and then with deionized water. Tracheal
cartilage was then cut into small pieces and defattened with chloroform: methanol (2: 1
v/v) solution. After this, the cut pieces were properly cleaned with deionized water. 0.5%
Pepsin solution in 0.5 M acetic acid was prepared. Cartilage was then hydrolyzed by the
already prepared 0.5 % pepsin (in 0.5 M acetic acid) at 4 ° C for 48 hours. The extract
was then separated from the tracheal pieces and the viscous solution obtained was
centrifuged at 12000 rpm for 1 hr at 4 "c. Now the collagen was expected to be in the
supernatant which was salted out by adding NaCI to a final concentration of 2.5M and
kept for almost 12-16 hrs. This collagen was again centrifuged at 12000 rpm for 1 hr at
4 C. The obtained collagen pallet was redissolved in 0.5 M acetic acid and then it was
dialyzed against 0.1 M acetic acid followed by dialysis with distilled water. The sample
after dialysis was put in petri dishes and kept in freezer for overnight to let it be prepared for
lyophilization. The frozen collagen sample was then lyophilized. After lyophilization, the sample
gave an appearance of a white mesh. This sample was reconstituted in PBS with pH 8 to run it on
SDS-PAGE. The procedure of SDS-PAGE in non reducing conditions was adopted for the
characterization of collagen type II in the sample. The description of results of SDS-PAGE is given
below:
Lane M contains protein markers of different molecular weight. Lane 1, 2 and 3 contains
samples at different steps of the whole procedure showing clear bands of collagen type II.
Lane 4 contains lyophilized sample of collagen type II showing the thickest band (alpha
chain of collagen type II). In this research, poultry waste has been used for making health improving
product. As in our country poultry is used in bulk quantity so if its waste might be used in any
medicinal product then it might not only be useful but also economical for such a developing country
as ours. Another thing is that as this collagen Type II has been extracted from poultry trachea, it
shows that tracheal cartilage is a rich source of such collagen type. Collagen Type II is used in the
cure of arthritis especially rheumatoid arthritis so through this research, it has been made clear that
poultry waste can be utilized in a positive way in medicinal industry and also that collagen Type II
acts as an effective neutraceutical.
Availability: Items available for loan: UVAS Library [Call number: 1330,T] (1).
7.
Pharmacokinetics Of Carvedilol In Dogs After Oral Administration
by Khurram Wajih Mahmood | Ms. Huma Rasheed | Dr. Mateen | Dr. Sualeha Riffat.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2011Dissertation note: Carvedilol, is a class-II, non-biowaivered drug, with low solubility. It is a candidate for several in-vivo studies including bioavailability and bioequivalence of generic versus standard, and also for testing performance of modified release products. Single dose pharmacokinetic study was performed on 12 healthy dogs using 25mg Carvedilol tablets. The objective of this study was to perform pharmacokinetic and biopharmaceutic study in the dog model for Carvedilol. The animals were selected after screening by veterinary practitioner. Blood samples were collected after 15min, 30min, 1 hr, 1.5 hr, 2 hrs, 4 hrs, 6 hrs, 8 hrs, 12 hrs and 24 hrs via an in-dwelling catheter from the cephalic vein of the animals along with one base line sample taken before drug administration. The plasma samples obtained by centrifugation were analyzed by HPLC quantitative method after checking the reproducibility and linearity of the standard curve using the standards prepared in dog plasma. Pharmacokinetic parameters were calculated by using APO software, and using appropriate compartmental pharmacokinetic model. The data derived from this study was analyzed using descriptive statistics and the observed results were compared with the published literature. The pharmacokinetic parameters investigated show that peak plasma concentration was 72.33±32.84 ng/ml, elimination half life of 1.84±2.42 hrs, Mean Residence Time was 2.98±0.96hrs, Volume of distribution of 0.57±0.6 l/kg and time to peak plasma concentration of 1.77±0.31hrs. The study defends the older proposition by pharmacokineticists that the Carvedilol shows unpredictable absorption kinetics in dogs and a few of the parameters also relate with the published finding on the Carvedilol pharmacokinetics in human. The delay in absorption and significant lag time of 1.23hrs was consistent in all subjects. The study elaborated the prospects of the possibility of using animal studies to achieve predictable pharmacokinetics of the drugs without involving human subjects.
Availability: Items available for loan: UVAS Library [Call number: 1423,T] (1).
8.
Comparison Of Dsingle-Dose Pharmacokinetics Of Candesartan Cilexetil In Healthy Male & Female
by Hafiz Awais Nawaz | Muhammad Irfan Masood | Dr. Mateen | Dr. Sualeha Riffat.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2012Dissertation note: This study was designed to compare the pharmacokinetic parameters of Candesartan in 8 healthy male and female volunteers. The study was conducted in eight healthy male volunteers and eight healthy female volunteers. Only those male volunteers were selected who aged between 18-30 years, not suffering from any disease. Female volunteers were also between age of 18-30 years, who were not pregnant and not suffering from any disease. Written consent was taken from them and they were informed about objectives of the study, frequency of blood sampling, and possible side effects of drug which they might face during the study. The male volunteers were considered as group A and healthy female volunteers were considered as group B. Both groups were administered Candesartan 16mg tablet orally to each individual. 5ml Blood samples were collected at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 12, 24, 48 & 72 hr after the oral drug administration from vein through 5ml B.D syringe of 22guage needle. Plasma was separated by centrifugation at 5000 RPM and stored at -80ºC till analysis. Candesartan concentrations in plasma were measured by HPLC method. All pharmacokinetic parameters were calculated by entering plasma concentration-time data in software APO pharmacological analysis MW/PHARM version 3.02 by assuming bio-availability of Candesartan after oral administration as 1. Pharmacokinetic parameters of Candesartan in healthy male and female volunteers were compared. Data was analyzed by unpaired t-test and it was observed that there is significant difference in AUC of Candesartan in healthy male and female volunteers after oral administration without any effect in Cmax, Tmax, volume of distribution, absorption rate constant or elimination half life. In general, candesartan produced comparable results in healthy male and female volunteers so there is no need of any dose adjustment during therapy in both genders.
Availability: Items available for loan: UVAS Library [Call number: 1442,T] (1).
9.
Bioequivalence Study Of Atorvastatin Tablets In Human Volunteers
by Asif Ali Bokhari | Dr. Sualeha Riffat | Prpf. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2012Dissertation note: Main purpose of this clinical trail was to evaluate bioequivalence parameters of two generic drug products. It was a randomized, single dose, two-period crossover trial. Study was done on 12 volunteers with the age limit of 18-45yrs. Inclusion and exclusion criteria was used for volunteers selection and the study conducted with two week washout period. Each volunteer received one tablet of atorvastatin (reference or test) 10mg. Almost 13 blood samples of 5ml were collected at predefined time intervals. Blood samples were collected in heparinized vacuette. Blood was centrifuged after sampling and stored at -80°C till analysis. Serum atorvastatin levels were examined by using high performance liquid chromatography (HPLC) method mobile phase was a mixture of Sodium di-hydrogen phosphate buffer and acetonitrile 65:35 v/v pumped at flow rate of 1ml/min at a wavelength of 260nm. Two compartmental analysis was used for evaluating bioequivalence parameters to evaluate the both drugs were bioequivalent or not .2 major parameters of bioequivalencepeak plasma concentration Cmax and area under the curve AUC 0-t were evaluated. By statistical analysis, 90% confidence interval for area under the curve AUC 0-t was found to be 0.5972 - 1.7093, it was not within the range (0.80 - 1.25) proving an in equivalence between the two products so it shows that area under the curve AUC 0-t for both drugs is not equivalent. By statistical analysis, 90% confidence interval for peak plasma concentration Cmax found to be 0.3840 - 3.6638., it was not within the range (0.80 - 1.25). So it is evident that peak plasma concentration Cmax for both drugs is not equivalent. So, it was concluded that both of the drugs were not bioequivalent. From the given data, it is concluded that both the drugs produced uncomparable results. So it can be concluded that Lipiget cannot be used in replacement of Lipitor.
Availability: Items available for loan: UVAS Library [Call number: 1480,T] (1).
10.
Preparation Of Low-Glycemic India Vetch-Wheat Composite Flours And Evaluation Of Their Chapatti Making
by Amara Khan | Dr. Muhammad Nasir | Dr. Sanaullah Iqbal | Dr. Sualeha.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2012Dissertation note: Wheat is one of the popular cereals that supply the basic nutritional and energy requirements of the population. More so, wheat flour is commonly consumed across the world. Complementation of wheat flour with Indian vetch will not only upgrade its protein quality but also will helpful in decreasing glycemic index because studies have shown effects of Indian vetch on glycemic index. Objectives of the present study are to develop low glycemic, nutritious composite flours and to assess the glycemic efficacy of selected composite flour based chapattisin normal adult human subjects.
The present study was conducted in two phases. During first phase composite flours were prepared and their chemical, functional and rheological properties were analyzed. In second phase the effect of sample chapattis on post- prandial glycemic response in healthy subjects was evaluated.
The composite flours were prepared by mixing various ratios of wheat flour and Indian vetch flour. The ratio of Indian vetch flour was 10, 20, and 30 g respectively with 90, 80, and 70g wheat flour. Chemical properties revealed that The results for the proximate composition of composite flour and wheat flour show that the moisture content of composite flours is lower than the wheat flour , which progressively decreased as the level of Indian vetch supplementation increased. The supplementation at different levels of Indian vetch flour (seed coat removed during milling) has a significant lowering effect on the crude fiber, ash and crude fat but a significant increase was observed in the protein content, which was due to high protein content of Indian vetch flour.
Mean square for bulk density of composite flour blends shows that bulk density was significantly affected by the Indian vetch flour addition (10-30Overall, bulk density ranged from 86.66±1.527 to 83.66±1.154 in all flour blends.
Water and oil absorption capacities are amongst the important functional properties for additives supplemented in food systems. Water and oil absorption are significantly affected with addition of Indian vetch). 30% Indian vetch Composite flour showed excellent water holding capacity 5.889±0.040% as compared to wheat flour 4.956±0.056%. The oil absorption capacity of composite flour was noted to be 5.64±0.032% that was significantly higher than that of wheat flour (T0). Therefore water and oil absorption capacities of flour blends were improved at all levels of Indian vetch flour addition.
Foaming capacity and stability were also significantly affected among different compositions of flours. T30 flour sample showed foaming capacity 9±0% and foaming stability 8.5±0%, whilst T0 wheat flour possessed 7.166±0.288% and 6.51±0.5% of foaming capacity and stability, respectively. The foaming stability of composite flours increased as the ratio of Indian vetch increased in present study. As expected, Indian vetch flour addition resulted a significant increase in the stability of foam in flour blends.
Gelling power of the flour dispersions increased with the level of Indian Vetch flour in flour blends. The highest gelling power was observed in T30 (30% Indian vetch flour). The partial gelation in T20 was observed at 4% flour suspension, whereas in T30 above 3% flour dispersion resulted in complete gelling. The lowest gelling properties were noticed in case of T0 (100% wheat flour).
It is evident from results that Indian vetch addition resulted in decreased redness ("a") and increased lightness ("L") . Hunter color values increased significantly with Indian vetch addition in composite flour , representing an increased yellowness of chapatti . The values for Chroma remained same while hue angle also increased momentously by adding up of Indian vetch.
Dough rheological behavior is mainly affected due to protein quantity and quality of flour. The rheological characteristics are the source for understanding the dough handling behavior in bakery. Consequently, dough properties play a key role in quality of finished products. Significant variations were observed among various flour samples for these traits.
On the basis of sensory evaluation two best chapatti samples T10 and T20 were selected for further efficacy studies.
A total of 10 healthy adult volunteers were recruited through flyers, emails and personal contacts. Eligibility for volunteers will be determined on the basis of age (20-50 years), health status, individuals having optimum BMI and free from any communicable diseases and gluten allergy. The study procedure was discussed with all volunteers and were asked to sign the consent to voluntarily participate in the study.
Predicted glycemic index was lower in chapattis added with 20% Indian vetch flour than in 10% composite flour and 100% wheat flour. So chapattis of composite flour might be a dietetic alternative forpeople with low-calorie requirements.
Availability: Items available for loan: UVAS Library [Call number: 1550,T] (1).
11.
Impact Of Nutritive And Non-Nutritive Sweeteners On Food Consumption Weight Gain And Blood Lipid Profile In Rats
by Uzma nazish | Dr. Muhammad Nasir | Dr. Sualeha | Ms. Frasat rizwan.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1911,T] (1).
12.
Assesment Of Postprandial Glycemic Response In Healthy Human With Respect To Some Promising Indigenous Mango Varieties Of Pakistan
by Afrah Jabeen (2014-VA-911) | Mr. Haroon Jamshaid Qazi | Dr. Sanaullah Iqbal | Dr. Sualeha Riffat.
Material type: ; Literary form:
not fiction
Publisher: 2016Dissertation note: Carbohydrates intake result in elevation of BGL. GI is a simple tool to select right carbohydrate foods while GL determines the overall effect of that food on human health. High GI/GL diets are directly associated with progression of diabetes type 2. Mango is ranked among medium glycemic index fruit with GI (51-55) and nutritionally it is rich in dietary fiber. Different mango types have different nutritional composition so it was very necessary to estimate postprandial glycemic response of various mango types to determine the possible positive impact of all varieties on overall human health.
Samples of six mango varieties were evaluated for various physico-chemical testing. About 50-gram available carbohydrate from each source i.e. glucose and six mango cultivars were provided to each study person. Later on, post prandial blood glucose of all 10 individuals with a time interval of 15 minutes was determined by finger-prick method up to 120 minutes.
ANOVA was used to analyze all assessed attributes statistically. Means were compared through Duncan’s multiple range test for significance. Significance level was defined as p≤0.0.5 SPSS version 20 was used for all statistical analysis.
Desi variety among all studied mango types reflected low GI and GL value.
Availability: Items available for loan: UVAS Library [Call number: 2697-T] (1).
