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1. Protective Effect Of Diltiazem Hydrochloride On Occurrence Of Alloxan Induced Diabetes In Rabbits

by Azeem, M | Dr.Muhammad Razzaq Ali | Dr.Haji Ahmad | Dr.Muhammad Sabir.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1998Dissertation note: An investigation was carried out to study the protective effect of calcium channel blocker i.e. diltiazem hydrochloride on occurrence of alloxan diabetes in rabbits and also to see the protective effect of a herbal mixture of medicines, i.e. Kalonji, Kasni and Maithee on occurrence of alloxan induced diabetes in rabbits. For this purpose, 20 rabbits were randomly divided into four groups i.e. A, B, C and D, comprising 5 rabbits in each and were provided food and water libitum. Each of the members of group A (control) were given 150 mg/kg body weight alloxan intravenously into ear vein. These animals were given food and water libitum for two days, then they were fasted over night and blood samples were collected for estimation of glucose and total protein. The results obtained showed significant increase in blood glucose level subsequent to the administration of alloxan. There was no change observed in total protein. The rabbits of group B were given 20 mg/kg body weight of Diltiazem hydrochloride intraperitoneally and after 15 minutes alloxan was administered intravenously. The results obtained showed significant increase in blood glucose level and no effect on total protein. Similarly the rabbits of group 'C' were given 40 mg/kg body weight of diltiazem hydrochloride intraperitoneally and then after 15 minutes 150 mg/kg body weight of alloxan was administered intravenously into ear vein. Blood samples showed significant decrease in blood glucose level and no effect on total protein. While rabbits of group-D were given 2 gm/kg body weight of herbal mixture orally, and then after two hours alloxan was administered intravenously. The data showed a significant rise in blood glucose level and again no effect on total protein. This showed that the herbal mixture had no protective effect. From this result, it is conceivable that diltiazem hydrochloride showed protective effect on occurrence of alloxan induced diabetes in rabbits and there was no effect on total protein whereas the herbal mixture did not have protective effect. Availability: Items available for loan: UVAS Library [Call number: 0577,T] (1).

2. Synthesis And Evaluation Of Biological Properties Of Derivatives Of Cephalosporins

by Rehmat Ullah, Major | Dr.Muhammad Sabir | Dr.Haji Ahmad | Dr.Muhammad Raziq Ali.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1999Dissertation note: This study was aimed at preparation and evaluation of the biological properties of cephradine. Schiff base transition metal complexes of cephradine were prepared. In the first step Schiff bases were prepared by condensation of the primary amine with a carbonyl compound. For this purpose pyridoxal HCI and salicylaldehyde were used. In the next step the prepared Schiff bases were chelated with metal salts using copper acetate and zinc acetate, here metal binds to polydenate ligands to form the ring structure, where metal is the part of the ring. In this way a three dimensional molecule was obtained which exhibited enhanced antibacterial activity in some cases and depressed activity in the others. The complexes were subjected to biological evaluation to find out the minimum lethal concentration of the new complexes and then it was compared with the parent drug. The standard organisms of S. aureus, .E.coli Pseudomonas aeruginosa and . pneumoniae were used to study the antimicrobial activity. Cephradine complexes showed a depressed activity against S. aureus, . E.coli and P . aemginosa. But the activity of CPC and CSC derivatives was found ten times enhanced against K. pneumoniae, when compared with the present drug. The haematological study revealed that the parent drug and the new derivatives did not have any deleterious effect upon the total erythrocyte count, haemoglobin concentration, leukocytic count, differential leukocytic count i.e., lymphocytes and polyrnorphs (neutrophils). Thus the new compounds were found to be as safe as the parent drug itself. Availability: Items available for loan: UVAS Library [Call number: 0602,T] (1).

3. Synthesis And Evaluation Of Bioilogical Properties Of Derivatives Of Ceftriaxone Sodium

by Shahid Zaigham | Dr.Muhammad Sabir | Dr.Muhammad Razaq Ali.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1999Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 0622,T] (1).



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