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Immunomodulatory Effects Of Coccidiostats In Broiler Chicks

by Fraaz Mahmood | Muhammed Akram Muneer | Manzoor | Muhammed Naeem | Faculty of Veterinary Sciences.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1991Dissertation note: This study indicated that Amprolium and Clopidol (Coyden 25) when used at recommended dosage levels (6.25 gm of pure drug/50 kg of feed & 25 gin of premix/50 kg of feed respectively) did not interfere with the body weight gain of birds; did not have adverse effects on weights of lymphoid organs such as bursa of Fabricius, spleen, thymus, liver; did not interfere with the development of serum antibody in vaccinated or vaccinated and challenged birds; their medication in feed had beneficial effects on serum antibody development; did not result in higher post-challenge mortality of vaccinated birds as compared to the non-medicated vaccinated control birds. The injection to baby chicks on first 4 consecutive post-hatching days with a known immunosuppressive agent (Cyclophosphamide) resulted in lower body weights, destruction of the bursa of Fabricius, poor antibody response of birds to vaccination against NDV, and very high post-challenge mortality, upon challenge with a virulent strain of NDV. The weight gain studies indicated that vaccinated and non-vaccinated birds on Amprolium and Clopidol medicated feeds had non-significantly higher body wegh ts that those on non-mothcateii ration at 42 days of age. Oopiclo) (Coyden 25), at recommended dosage level, had more beneficial effects on the body weights than the Amprolium. These studies further indicated that vaccinated birds kept on Clopidol medicated feed had significantly higher serum antibody titres on day 42 than the vaccinated non-medicated control birds. The serum antibody titres of vaccinated birds on Clopidol medicated feed were significantly higher than those fed Amprolium at recommended dosage levels. From the results of this study it is concluded that Clopidol and Amprolium are not immunosuppressive drugs when used at recommended dosage levels. They rather have beneficial effects on growth 1)erforr1arIce and immune response of birds. However, there is a need for further investigations. Availability: Items available for loan: UVAS Library [Call number: 0256,T] (1).

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Sero-Epidemiology Of Rinderpest & Bovine Viral Diarrhea (Mucosal Disease) In Sheep And Goats

by Amjad Hassain | Muhammed Amin Sheikh | Manzoor | Muhammed Akram Muneer | Faculty of Veterinary Sciences.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1992Dissertation note: The present study was conducted to find out the prevalence of rinderpest and bovine viral diarrhea virus antibodies in the sera of sheep and goats. For this purpose, 1000 serum samples were randomly collected from four different sources. The samples were distributed uniformly from each species i,e.. sheep and goats from all the four sources. Agar gel-immunodiffusion (PGID) test was employed for the investigations. The results of the study revealed that overall 4.2% sheep sera were having rinderpest viurs antibodies while 1.6% sheep sera were possessing antibodies to bovine viral diarrhea virus. Goat sera tested demonstrated that 2.4% were having rinderpest virus antibodies whereas only 1.0% were possessing antibodies against bovine viral diarrhea virus. It is observed that there is higher prevalence rate of rinderpest virus and bovine viral diarrhea virus antibodies in sheep as compared to goats. The findings of this project revealed a moderate exposure, of sheep and goat population surveyed, to the pathogens of both the diseases. However further research is suggested for realistic determination of the role of sheep and goats in epidemiology of these menaces and the resultant revival of the control measures.. Availability: Items available for loan: UVAS Library [Call number: 0285,T] (1).

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Immunogenic Studies On Temperature Resistant V4 Strain Of Newcastle Disease Virus

by Sakhawat Hussain, Shah | Sheikh Muhammed Amin | Manzoor | Muhammed Akram Muneer | Faculty of Veterinary Sciences.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 1993Dissertation note: This experiment was conducted to study the immunogenic response of '14 strain of NOV which was administered through different routes normaly practiced in Pakistan (eyedrop, drinking water, subcut and intramuscular) Birds in group A were vaccinated intraocularly on 7th day of age and then on 21st day of age they were again vaccinated subcutaneously with '14 strain of NOV . The GMT titer on 12nd day of their. age was 169 and they showed 757. survival when challenged with VVNDV. Group B was administered V4 strain of NDV in drinking water twice on 7th day of age and on 21st day of age. Their GMT HI titre on 42nd day was 104 .They showed 70%. protection percentage when challenged with virulent virus. Chicks of group C were vaccinated introcularly with V4 strain on 7th day of their age and intramuscularly on 21st day of their age with V4. Their sera when analysed on 42nd day of age indicated GMT HI titre of 181. They showed highest protection 807. when , Challenged with virulent virus. Group 0 was vaccinated intraocularlywith Mukteswar strain of MDV on 7th day again substaneously on 2lth day . Their GMT H.I titre was 194 on 42nd day of age. Challenged with VVNDV protected 85% birds. This study indicates that V4 strain of NOV induces higher H I titer and protection percentage when administered 1/rn than S/C and drinking water routes. However Mukteswar strain gives more HI titer and protection than V4 strain through S/C route. Availability: Items available for loan: UVAS Library [Call number: 0307,T] (1).

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