51.
Chemical Characterizaton And Toxicological Screening Of Auto-Rickshaw Emissions Particulate
by Khaleeq Anwar | Prof. Dr. Muhammad Ashraf | Dr. Aftab | Dr. Aqeel Javeed.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2013Dissertation note: Vehicular air pollution is a mounting health issue of the modern age, particularly in urban populations of the developing nations. Auto rickshaws are not considered eco-friendly as to their inefficient engines producing large amount of particulate matter (PM), which poses a significant environmental threat.
Major transformations in the environmental composition are principally attributable to the combustion of fuels by automobiles. Motorized gasoline powered two-stroke auto-rickshaws (TSA) and CNG powered four-stroke auto-rickshaws (FSA)are major sources of air pollution in south Asia and produce toxic amount of PM to the environment. In this study, during the first phase, the PM of TSA and FSA was characterized by using proton induced x-ray emission (PIXE) analysis. The observations of the existing investigation recognized significant increase in Al (P < 0.05), P (P < 0.01), and Zn (P < 0.01) from the PM samples of FSA. In addition, the concentrations of Cu, Fe, K, Mn, Mg, Na, S and Si were also observed exceeding the recommended NIES limits. On the contrary, increased concentration of Sr and V were observed in the PM samples from TSA. It is generally believed that FSA generates smaller amount of PM but the data obtained from this study clearly shows that emissions from FSA are comprised of potentially more toxic substances than TSA. The current research is specific to the metropolitan population and has evidently revealed an inconsistent burden of exposure to air pollutants engendered by FSA in urban communities, which could lead to disruption of several biological activities and may cause severe damage to entire ecological system.
The second phase of this study was conducted to ascertain toxic effects on angiogenesis, embryo development, embryonic movement and phytotoxicity of the PM from TSA and CNG powered FSA. Based on high amounts of aluminum quantified during PIXE analysis of PM from TSA and FSA, different concentrations of aluminum sulfate were also tested to determine its eco-toxicological potential. The PM solution from FSA, TSA and Aluminum sulfate exhibited anti-angiogenic potential with reduction in total area of CAM. Morphological evaluation of embryos exhibited varying degrees of hemorrhages in different groups. In case of phytotoxicity screening using Zea mays, the results demonstrated that all three tested materials were equally phytotoxic at higher concentrations in seed germination(p<0.001). Aluminum sulfate proved to be a highly phytotoxic agent even at the lowest concentration examined.
During the last phase, of the study, the MTT assay demonstrated a significant (p<0.001) dose dependent cytotoxic effect for TSA, FSA and aluminum sulfate on the BHK-21 cell line, establishing that the PM from FSA is a highly cytotoxic material. Mutagenicity was assessed by fluctuation Salmonella reverse mutation assay adopting TA100 and TA98 mutant strains with (+S9) and without (-S9) metabolic activation. Despite the fact that different concentrations of PM from both sources i.e. TSA and FSA were highly mutagenic (p<0.001) even at lower concentrations, the mutagenic index was higher in TSA. The chronic toxicity study revealed that chronic exposure to PM emitted from FSA and TSA resulted in peribrochiolitis, emphesema and infilteration of leukocytes in lung tissues. On the other hand liver, cardiac and kidney tissues exhibited degeneration and necrosis. The data shows that all tested materials are equally ecotoxicand if the existing trend of atmospheric pollution by auto-rickshaws is continued, air-borne metals/heavy metals will seriously affect the normal growth of local inhabitants and increased contamination of agricultural products, which will amplify the dietary intake of toxic element and could result in genetic mutation or long-term health implications.
Availability: Items available for loan: UVAS Library [Call number: 1795,T] (1).
52.
Genotoxic and Mutagenic Potential of Anti-Diabetic Drugs (Sitagliptin and Metformin) Alone And In Combination With Artificial Sweeteners.
by Komal Najam | Prof. Dr. Muhammad Ashraf | Dr. Imran Altaf | Dr. Muhammad Adil Rasheed.
Material type: ; Format:
print
Publisher: 2013Dissertation note: Metformin most commonly prescribed oral anti hyperglycemic drug for type 2 diabetes whereas Sitagliptin recently approved oral antidabetic drug for type 2 diabetes were evaluated for their mutagenic and genotoxic potential alone and in combination with three artificial sweeteners (Saccharin, Aspartame and Acesulfame-K) normally consumed by diabetic individuals.
In this research project Ames Salmonella/microsome assay was performed to check the mutagenicity of Metformin and Sitagliptin alone and in combination with artificial sweeteners using mutant Salmonella tester strains TA100 and TA98 with and without the S9 whereas Genotoxicity was evaluated by Single Cell Gel Alkaline Electrophoresis/Comet.
The results indicated that Metformin alone showed mutagenic effect at 120µg/plate against TA100 with S9mix. However Metformin when tested in combination with artificial sweeteners, significant enhance in mutagenicity occurred only against TA100 with and without S9. Sitagliptin displayed mutagenic potential only to TA98 with S9mix at the concentration of 3040µg/plate. In addition significant enhance in mutagenicity occurred when tested in combination with artificial sweeteners against both strains with and without S9. In case of genotoxicity both Metformin and Sitagliptin results indicated significant increase in DNA damage in dose dependant manner as compared to negative control. Though Metformin and Sitagliptin in combination with artificial sweetener did not reveal any significant boost in the genotoxicity relative to when they were tested alone.
Availability: Items available for loan: UVAS Library [Call number: 1799,T] (1).
53.
Effect Of Aqueous Extract Of Leaves Of Acacia Nilotica On Angiogenesis.
by Muhammad Yasin | Dr. Muhammad Adil Rasheed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1803,T] (1).
54.
Comparative Anthelmintic Efficacy Of Calotropis Procera Leaves And Moxidectin With Particular Reference To Biochemical Changes in Sheep
by Qamar Niaz | Prof. Dr. Muhammad Ashraf | Dr. Aneela | Mr. Muhammad Adil Rasheed.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Background:
This project was designed to evaluate the anthelmintic efficacy of Chloroformic extract of Calotropis procera leaves against sheep nematodes. For this purpose hundred sheep positive for nematodal infection in BLPRI Kherimurat were selected after fecal examination.
Methodology:
The hundred animals were divided into 5 groups (Group A, Group B, Group C, Group D and Group E) having 20 animals in each group. Fecal eggs counts (EPG) and biochemical tests like the Alanine aminotransferase (ALT), Aspapartate aminotransferase (AST), Alkaline phosphatase (ALP), Albumin, Bilirubin, Creatinine and Urea were done on the day zero of the treatment. For further study, Group A served as an un-treated control. Group B, Group C and Group D were given the Chloroformic extract of Calotropis procera leaves at the dose rate of 3, 6 and 12mg/kg body weight by oral route respectively. Group E was given the Moxidectin at the dose rate of 0.2mg/kg body weight by subcut route. The biochemical tests on the day 3 showed no change in the normal level of the ALT, AST, ALP, Albumin, Bilirubin, Creatinine and Urea. The fecal EPG of all the groups were done on the day 7th and day 14th post treatment. The efficacy of the Group A and Group B was 0% both on day 7th and day 14th post treatment. The efficacy for the Group C was 19.40% and 42.53 % on the day 7th and day 14th post treatment respectively. The Group D showed the efficacy of 80.215% on day 7th and 91.36% on the day 14th of the treatment. The efficacy for the Group E was 85.97% and 93.29% on the day 7th and 14th respectively.
Statistics:
The data from the fecal eggs count and biochemical tests were analyzed by using the ANOVA and LSD.
Conclusion:
The Chloroformic extract of the Calotropis procera leaves have maximum anthelmintic effect at the dose rate of 12mg/kg body weight having no biochemical changes in the blood.
Availability: Items available for loan: UVAS Library [Call number: 1804,T] (1).
55.
Evaluation Of Cytotoxic, Antiviral And Mutagenic Potential Of Micronutrient Combination (Iodin, Potassium Iodide AndAscorbic Acid) In Vitro Cell Culture
by Nazish Matti | Prof. Dr. Muhammd Ashraf | Dr. Muhammad Adil Rasheed | Prof. Dr.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Iodine has been proved over an extended period of time as antimicrobial especially antiviral and is employed extensively as skin disinfectant. Ascorbic acid also possesses antioxidant and antiviral activities. A micronutrient combination consisting of iodine, ascorbic acid, potassium iodide and excipients have been developed to cope with increasing burden of viral infections in Pakistan and particularly against Hepatitis C Virus clinically. The objective of this project was to analyze antiviral activity, cytotoxic and mutagenic potential of micronutrient combinationthrough H9N1 influenza virus strain antiviral infectivity assay, MTT cell viability assay and Ames Salmonella test, respectively. Commercial preparation of micronutrient combination i.e. MTI Renessans, comparable self-prepared micronutrient UVAS Renessans, pharmaceutical grade individual ingredientsand standard antiviral Ribavirin, Amantadine and Oseltamivir were tested.Renessan's concentrations of 375, 187.5, 93.75, 46.87, 23.43, 11.71, 5.86, 2.93, 1.46, and 0.73ug/ml were employed in these tests while comparable concentrations of UVAS-Renessans and individual micronutrients were analyzed. Ribavirin, Amantadine and Oseltamivir had doubling dilution from 100ug/ml concentrations 14 in descending manner. In MTT assay, confluent monolayer of Chicken Embryo Fibroblasts grown in 96-well cell culture plates were treated with ten concentrations of each extract in triplicate manner and was used to determine the viability of the cells and cell survival percentage was calculated.Antiviral efficacy was determined against influenza virus H9N1 strain by virus infection and subsequent cell viability assay. Cytotoxicity was measured by cell survival analysis after tetrazolium reduction assay (MTT assay) while mutagenicity was measured by bacterial reverse mutation analysis by Amestestusing two strains of Salmonella typhimurium TA100 and TA 98 with and without S9 and after appropriate incubation, number of revertant colonies per plate were counted in triplicate manner and Mutagenic Index MI was calculated. Our combination showed cytotoxicity at doses higher than 93 ug/ml while showed significant antiviral efficacy at concentrations of 93ug/ml, 46ug/ml, 23ug/ml, 11.5 ug/ml, 5.86ug/ml and 2.93ug/mlwhich faded away at lower dilutions. Renessans was found to be non-mutagenic in our experiment. The results are well supported by previous studies and may show a paradigm shift in systemic use of high dose of iodine as antiviral compounds.
Availability: Items available for loan: UVAS Library [Call number: 1825,T] (1).
56.
Reversal Of Antibiotics Resistance In Methicillin-Resistant Staphylococcus Aureus By Non-Antimicrobial Agents
by Sohaib Danyaal | Prof. Dr. Muhammad Ashraf | Dr. Aftab | Dr. Muhammad Adil Rasheed.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Antibiotic resistance is increasing along with the increasing use of antibiotic for the treatment of infectious diseases. The in-vitro study was designed to observe the reversal of
antibiotics resistance in Methicillin-resistant Staphylococcus aureus by non-antimicrobial
agents.
One hundred pus samples were processed for isolation and identification of MRSA.
Out of 100, 37 (37%) islotes were Gram +ve cocci, from these 37 isolates 34 (92%) turn red
colour of mannitol salt media to yellow and 23 (62%) gave +ve catalase and coagulase. In
this study Antibiotic Sensitivity Test was performed on pure culture of MRSA strain by
applying disc diffusion method. Out of 23 pure MRSA isolate, 100% isolates were
methacillin resistant, 79% isolates were co-amoxiclav resistant, 30% isolates were
meropenum resistant, 8% isolates were vancomycin resistant, 26% isoltes were moxifloxacin
resistant and 39% isolates were linezolid resistant. Reversal of antibiotics resistance was
observed by MIC or serial dilution method, using non antibiotic agents like Amiloride,
Lansoprazole and Promethazine, Concentrations of non-antibiotic agents 1024ìg, 512ìg,
256ìg, 128ug, 64ìg and 32ìg were used in combination of antibiotics to reverse the
antibiotics resistance in MRSA. These non antibiotic agents may cause the alteration in
mechanisms by which microorganism develop resistance. The collected data analyzed by
applying analysis of variance (ANOVA) through SPSS 16.0 computer software. Now we would be
able to treat some lethal infection caused by MRSA, and help to increase patient compliance
and decrease the cost of therapy.
Availability: Items available for loan: UVAS Library [Call number: 1828,T] (1).
57.
Effect Of Eugenia Jambolana (Jamun) Seeds And Leaves Etract On Angiogenesis
by Muhammad Javed Iqbal | Dr. Aqeel Javedd | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: The present study was designed to explore the effects of aqueous and ethanolic extract of leaves and seeds of Eugenia jambolana on angiogenesis by means of the chicken chorioallentoic membrane assay. The Eugenia jambolana was collected from the locality of Lahore. Sequential dilutions were made with distilled water. Eggs were taken from local hatchery and divided into 4 groups. Each group was comprised of five eggs. The eggs were incubated at 37 C0. At day 4, 3-4 ml albumin was removed with the help of syringe. At day 5, sample solutions of various concentrations were applied to chorioallentoic membrane (CAM). After 24 hours, the change in CAM was observed by taking the images. SPIP was utilized for computerized measurements of the diameter of blood vessels and CAM. Overall area of the CAM was also drastically minimized among all groups treated with sample solutions.
The data was analyzed for statistical analysis by using SPSS software (version 13 for windows). ANOVA was performed to determine significance among different groups. The value of P<0.05 was considered as significant.
Different extracts of Eugenia Jambolana exhibited anti-angiogenic potential in the following order. WS > WL = ES > EL. In case of WS 4% solution area of CAM is 285.66 mm2, WL 4% 586.77 mm2, ES 4% 567.47 mm2 and EL 4% 634.23 mm2 while in case of negative control area of CAM 2473 mm2 . The extracts exhibited anti-angiogenic potential in variable magnitude. Dilutions of water extract of seeds exhibited most anti-angiogenic potential (p<0.01) in comparison to other treated groups. Collectively, these observations show that extract of Eugenia jambolana seeds and leaves contains polar compounds that ceased growth, primary vessel formation and cell propagation in CAMs.
Availability: Items available for loan: UVAS Library [Call number: 1830,T] (1).
58.
Evaluation Of Antiviral Activity Of Allium Sativum, Allium Cepa, Zingiber Officinale Against Avian Influenza H9
by Sadia Nazir | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2013Dissertation note: Plant products play an important role because of their medicinal activity. A wide variety of active phytochemicals peptides have been found to possess therapeutic applications against various functionally and genetically diverse viruses. Influenza A viruses (IAV) causes acute respiratory diseases in humans, birds, and other mammals, representing one of the major threats to public health.
In this study, the antiviral activity of Allium sativum L., Allium cepa L., and Zingiber officinale Roscoe against Avian Influenza H9 virus was evaluated in ovo. The aqeous extracts of Allium sativum L., Allium cepa L., and Zingiber officinale Roscoe were prepared by using macerate technique. From the macerate, nine different dilutions i.e. 8000 ƒÊg/ml, 4000 ƒÊg/ml, 2000 ƒÊg/ml, 1000 ƒÊg/ml, 500 ƒÊg/ml, 250 ƒÊg/ml, 125 ƒÊg/ml, 62.5 ƒÊg/ml and 31.25 ƒÊg/ml of the extracts were prepared in normal saline. For each plant extract; Allium sativum L., Allium cepa L., Zingiber officinale Roscoe 100 embryonated chicken eggs were assigned to 20 groups, each group containing 5 embryonated chicken eggs (nine for antiviral activity, nine for cytotoxic activity, and two groups were kept positive and negative control respectively) and marked them with lead pencil. The different concentrations of the plant extracts were mixed with virus and 0.2 ml inoculum was inoculated to 9th to 10th day embryonated chicken eggs along with positive and negative controls containing only virus and normal saline respectively. The embryonated chicken eggs were incubated at 37oC and were checked after 12-72 hrs. After 72 hr post inoculation, all the eggs were chilled in refrigerator at 4oC for 12 hrs and the allantoic fluid was harvested. The antiviral activity was calculated as embryo survival percentage, positive or negative spot Hemagglutination activity and determination of virus titre by Hemagglutination Test. The cytotoxicity of Allium sativum L., Allium cepa L., Zingiber officinale Roscoe extracts was evaluated by only inoculating the extracts of respective concentrations as used for antiviral activity in embryonated chicken eggs and incubating for 72 hrs. The results were analyzed by ANOVA by means of SPSS.
All the concentrations of Allium sativum L. were non toxic while three concentrations showing antiviral activity were 8000 ƒÊg/ml, 4000 ƒÊg/ml and 2000 ƒÊg/ml. While in case of Allium cepa L. all the concentration i.e. 8000 ƒÊg/ml, 4000 ƒÊg/ml, 2000 ƒÊg/ml, 1000 ƒÊg/ml, 500 ƒÊg/ml, 250 ƒÊg/ml, 125 ƒÊg/ml, 62.5 ƒÊg/ml and 31.25 ƒÊg/ml were non cytotoxic and five concentrations i.e. 8000 ƒÊg/ml, 4000 ƒÊg/ml, 2000 ƒÊg/ml, 1000 ƒÊg/ml and 500 ƒÊg/ml show potent antiviral activity. In case of Zingiber officinale Roscoe two concentrations 8000 ƒÊg/ml, 4000 ƒÊg/ml were virucidal and all concentration 8000 ƒÊg/ml, 4000 ƒÊg/ml, 2000 ƒÊg/ml, 1000 ƒÊg/ml, 500 ƒÊg/ml, 250 ƒÊg/ml, 125 ƒÊg/ml, 62.5 ƒÊg/ml and 31.25 ƒÊg/ml were non cytotoxic. So the present study suggested the presence of antiviral activity of plant extracts of Allium sativum L., Allium cepa L., Zingiber officinale Roscoe, so they can be used for prevention and treatment of various viral diseases.
Availability: Items available for loan: UVAS Library [Call number: 1836,T] (1).
59.
Role Of Non-Antimicrobial Agents In Reversal Of Antibiotic Resistance In Escherichia Coli
by Kalim Ullah | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Prof. Dr. Aftab.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1839,T] (1).
60.
Evaluation Of Ynergistic Efficacy Of Quinolones, Amino Glycosides, Cephalosporin And Co-Trimoxazole
by Tyyaiba Azam | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Background
Opportunistic pathogens represent the type of pathogens which infects only those individuals
with impaired immune system and lead to diseases that can be severe, debilitating and difficult to
treat in immunocompromized host. These opportunistic pathogens include different bacteria,
viruses and fungi. This study was designed to identify the opportunistic bacterial pathogens
pseudomonas and Citrobecter in immunocompromized chronic liver disease (CLD) patients.
This study was performed to analyze sensitivity pattern of bacterial pathogens to commonly used
antibiotics quinolones, aminoglycosides, cephalosporin and co-trimoxazole and to evaluate the
synergistic efficacy of different combination s of antibiotics. The study was conducted on
different CLD patients admitted in different medical wards of Sir .ganga Ram Hospital Lahore.
Aim
By using blood and urine culturing technique and different biochemical tests opportunistic
pathogens Pseudomonas and Citrobecter in CLD immunocompromized patients belonging to
different age group were determined. Combination therapy of quinolones, aminoglycosides,
cephalosporin and sulpha drugs were effective against the bacterial pathogens Pseudomonas and
Citrobecter.
Material and Methods
Clinical sign and symptoms of all the CLD patients who were admitted in the hospital were
noted at the time of admission The patients who start showing sign and symptoms (Fever,
burning micturation, pain) of suspected infection on 2nd and 3rd day of their admission were
included in this study. Blood and urine samples were collected from infected CLD patients with
CHAPTER – 6
SUMMARY
suspected sign and symptoms by using all necessary aseptic precautions with the assistance of
trained professionals. The pathogens were isolated, identified and purified by selective culturing
methods, which were subjected to active growth, during which sensitivity to different antibiotics
was checked. Antibiotic sensitivity test was conducted on pure culture isolates employing the
Kirby Bauer disc diffusion method for the commonly used antibiotics. The diameters of growth
inhibition around the discs was measured and interpreted by using Clinical Laboratory Standards
Interpretations (CLSI).
Statistical Analysis
The collected data was analyzed by ANOVA and Chi-square test on SPSS software (16) .
Results
Pseudomonas and Citrobecter pathogens are now proved to be a multi resistant pathogens and
use of combinations of antibiotics against these pathogens found to be more effective. This study
was performed to evaluate the synergistic effect of different antibiotics combinations against
Pseudomonas and Citrobecter pathogens, so that the chances of recurrent infections among the
immunocompromized hospitalized patients were minimized. It will help to improve the quality
of life of immunocompromized patients through providing information about effective antibiotic
treatment. The effects of different combinations of antibiotics were also analyzed in CLD
patients through evaluating the improvement in infectious disease. It was found during study that
combination of ceftriaxone and amikacin prove to be more effective in clinical settings but in
vitro studies shows the combination of cephradine with gentamycin was 97% susceptible.
Availability: Items available for loan: UVAS Library [Call number: 1841,T] (1).
61.
Evaluation Of Antimicrobial Therapy In Neonatal Sepsis
by Shazia Khanum | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Mr. Allah.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2013Dissertation note: Background: Sepsis is the presence of bacteria in blood. Neonatal sepsis indicates bacterial blood stream infection (BSI), such as gastroenteritis meningitis, pyelonephritis, pneumonia which results in fever in neonates (Weber et al. 2003). This study was designed to check the bacteriology and sensitivity pattern of microbes causing sepsis in neonates. In this study microbial susceptibility testing against antibiotics and pattern of resistance of microbes in septic patients was determined. It was conducted on neonates suspected from sepsis in Sir Ganga Ram Hospital Lahore, Pakistan. Hypothesis: By using blood cultures and different biochemical tests bacterial etiological agents of neonatal sepsis were determined and their sensitivity pattern and empirical therapies were evaluated. Material & Methods: Blood samples were collected from septic neonates admitted in Sir Ganga Ram Hospital keeping all necessary aseptic precautions with the assistance of trained professionals. The pathogens were isolated, identified and purified by selective culturing methods, which were subjected to active growth, during which sensitivity to different antibiotics were checked. The sensitivity was measured by area marked by the zone of inhibition, and National Committee for Clinical Laboratory Standards (NCCLS). Standard limit was a key indicator towards resistant bacteria. Statistical Analysis: The collected data was analyzed by appropriate statistical procedure. Outcome: It was designed to isolate and identify the pathogens responsible for neonatal sepsis and to see the effects of different antibiotics regimens for treatment of neonatal sepsis by evaluating the improvement in clinical condition, rate of complications of disease and incidence of death due to this fatal disease.
Availability: Items available for loan: UVAS Library [Call number: 1843,T] (1).
62.
Identification Of Bacterial Etiological Agent,Sensitivity Patern And Clinical Outcome Of Patients With Nasogastric Tube Associated Nosocomial Infection in Tertiary Care Hospital
by Kiran Hussain | Dr Muhammad Adil Rashid | Dr Shahnaz Akhtar | Prof Dr | Bio sciences.
Material type: ; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1864,T] (1).
63.
Comparative Mutagenic And Cytotoxic Evaluation Of Tamsulosin And Ciprofloxacin
by Faiza qamar | Dr. Muhammad Adil rasheed | Prof. Dr, Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1875,T] (1).
64.
Toxicological Evaluation Of Cetrimimide Chlorhexidin And Thiomersal Alone And In Combination
by Toseef Fatima Noshahi | Prof. Dr. Muhammad Ashraf | Dr.Imran Altaf | Dr.Muhammad Adil Rasheed.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1880,T] (1).
65.
Evaluation Of Cellular And Humoral Immune Responses Of Betamethasone In Mice
by Saima Batool | Dr. Aqeel javeed | Prof. Dr Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1881,T] (1).
66.
Comparative Mutagenic And Cytotoxic Evaluation Of Ibuprofen And Chloroquine
by Hunainah Khaliq | Dr. Adil rasheed | Prof Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1944,T] (1).
67.
Evaluation Of Immunomodulatory Activity Of Lornoxicam In Mice
by Zubaria malik | Dr.Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1945,T] (1).
68.
Evaluation Of Analgesic Anti-Pyretic And Anti-Inflammatory Activity Of Aqueous Methanolic Exteacts Of Euphorbia Granulata in Rats
by Muhammad Liaqat iqbal | DRr. Aqeel javeed | Prof. Dr. Nuhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1987,T] (1).
69.
Evaluation Of Analgesic Anti-Inflammatory And Anti-Pyretic Activity Of Aqueous Methanolic Extract Of Jatropha Gossypifolia in Rats
by Mohsin Ahmad Ghauri | DR. Aqeel Javeed | Prof. Dr Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1988,T] (1).
70.
Genotoxic Mutagenic And Cytotoxic Potential Of Metformin And Celecoxib Alone And In Combination
by Asad ullah | Prof/ Dr. Muhammad Ashraf | Dr. Aqeel javeed | Prof. Dr. Aftab.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1989,T] (1).
71.
Protective Effect Of Vitamin A And E On The Toxicity Induced By The Hydroquinone
by Saima | Dr. MUhammad Adil rashid | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1995,T] (1).
72.
Cytotoxicity Mutagenicity And Genotoxicity Potential Of Carvedilol And Celecoxib Alone And In Combination
by Ali attiq | Prof.Dr. Muhammad Ashraf | DR. Aqeel Javeed | Prof. DR. Aftab.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2004,T] (1).
73.
Evaluation Of Immunomodulatory Activity Of Tenoxicam In Mice
by Fatima nasim | Dr. Aqeel javeed | Dr. Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2025,T] (1).
74.
Evaluation Of Antibacterial Activity Of Macrolides In Combination With Levamisole Hc1 Against Different Pathogenic Bacteria
by Sheeza javaid | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil rasheed | Proff. Dr. Aftab.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2026,T] (1).
75.
Bioequivalence Study Of Simvastatin In Healthy Human Volunteers
by Rana muhammad wasim shahzad | Dr. Muhammad adil rasheed | Prof. Dr. Muhammad ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2044,T] (1).
76.
Evaluation Of Antiviral And Cytotoxic Activity Of Parthenium Hysterophorusagainst Peste Des Petits
by Aina asghar | Dr. Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2051,T] (1).
77.
Effect Of Calcium Hypochlorite And Chloramine On Blood Biochemistry And Sodium Pentobarbital Induced Sleeping
by Sidra ishaq | Dr. Muhammad Adil rasheed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2062,T] (1).
78.
Effect Of Gemifloxacin On Cellular And Humoral Immune Response In Mice
by Muhammad Umair | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2088,T] (1).
79.
Toxicity And Immunomodulatory Activity Of Ketoprofen In Vitro And In Vivo
by Dawood Ahmad Hamdani | Dr. Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2090,T] (1).
80.
Evaluation Of Antihistaminic And Anticholinergic Activity Of Aqueous And Alcoholic Extracts Of Equisetum Debile
by Shahrukh Ali | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2097,T] (1).
81.
Evaluation Of Antihistaminic And Anticholinergic Activity Of Aqueous And Alcoholic Extracts Of Piper Betel And Murraya Koenigii Plants
by Hassan Mahmood Qureshi | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2098,T] (1).
82.
Cytotoxicity & Antiviral Profile Of Equisetum Debile (Bansi Booti) Against Food And Mouth Disease Virus In -Vitro Cell Culture
by Naeem Rasool | Dr. Muhammad Ovais omer | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2105,T] (1).
83.
Antibacterial And Cytotoxic Evaluation Of Aqueous Ethanolic And Chlorooform Extracts Of Parthenium Hysterophorus
by Sidrah Shoaib | Dr. Muhammad Adil Rasheed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2109,T] (1).
84.
Synergistic Effect Of Antimicrobial Agents In Combination With Colistin Against Bacterial Isolates From Patients
by Sahar Safdar | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Prof. Dr. Aftab.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2123,T] (1).
85.
Evaluation Of Immunomodulatory Activity Of Aceclofenac In Mice
by Hammad Asif | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2125,T] (1).
86.
A New Inclination Of Derived Tetrahydro-Carbazole Towards Anti-Inflammatory Analgesic And Antipyretic Activity
by Kinza Kanwal | Prof. Dr. Muhammad Ashraf | Dr. Aqeel Javeed | Mr. Malik Allah.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2136,T] (1).
87.
Evaluation Of Mutagenicity And Genotoxicity Of Furosemide And Propranolol Alone And In Combination Using Ames Test And Single Cell Gel Electrophoresis (Comet) Assay
by Sadaf Naz | Dr. Muhammad Adil rasheed | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2158,T] (1).
88.
Efficacy Of Cephalosporins Alone And In Combination With Zinc Sulphate In Tients With Post Surgical Infection
by Maria Naeem | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: ; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2166,T] (1).
