51.
Role Of Non-Antimicrobial Agents In Reversal Of Antibiotic Resistance In Escherichia Coli
by Kalim Ullah | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Prof. Dr. Aftab.
Material type: Book; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1839,T] (1).
52.
Evaluation Of Ynergistic Efficacy Of Quinolones, Amino Glycosides, Cephalosporin And Co-Trimoxazole
by Tyyaiba Azam | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
drama
Publisher: 2014Dissertation note: Background
Opportunistic pathogens represent the type of pathogens which infects only those individuals
with impaired immune system and lead to diseases that can be severe, debilitating and difficult to
treat in immunocompromized host. These opportunistic pathogens include different bacteria,
viruses and fungi. This study was designed to identify the opportunistic bacterial pathogens
pseudomonas and Citrobecter in immunocompromized chronic liver disease (CLD) patients.
This study was performed to analyze sensitivity pattern of bacterial pathogens to commonly used
antibiotics quinolones, aminoglycosides, cephalosporin and co-trimoxazole and to evaluate the
synergistic efficacy of different combination s of antibiotics. The study was conducted on
different CLD patients admitted in different medical wards of Sir .ganga Ram Hospital Lahore.
Aim
By using blood and urine culturing technique and different biochemical tests opportunistic
pathogens Pseudomonas and Citrobecter in CLD immunocompromized patients belonging to
different age group were determined. Combination therapy of quinolones, aminoglycosides,
cephalosporin and sulpha drugs were effective against the bacterial pathogens Pseudomonas and
Citrobecter.
Material and Methods
Clinical sign and symptoms of all the CLD patients who were admitted in the hospital were
noted at the time of admission The patients who start showing sign and symptoms (Fever,
burning micturation, pain) of suspected infection on 2nd and 3rd day of their admission were
included in this study. Blood and urine samples were collected from infected CLD patients with
CHAPTER – 6
SUMMARY
suspected sign and symptoms by using all necessary aseptic precautions with the assistance of
trained professionals. The pathogens were isolated, identified and purified by selective culturing
methods, which were subjected to active growth, during which sensitivity to different antibiotics
was checked. Antibiotic sensitivity test was conducted on pure culture isolates employing the
Kirby Bauer disc diffusion method for the commonly used antibiotics. The diameters of growth
inhibition around the discs was measured and interpreted by using Clinical Laboratory Standards
Interpretations (CLSI).
Statistical Analysis
The collected data was analyzed by ANOVA and Chi-square test on SPSS software (16) .
Results
Pseudomonas and Citrobecter pathogens are now proved to be a multi resistant pathogens and
use of combinations of antibiotics against these pathogens found to be more effective. This study
was performed to evaluate the synergistic effect of different antibiotics combinations against
Pseudomonas and Citrobecter pathogens, so that the chances of recurrent infections among the
immunocompromized hospitalized patients were minimized. It will help to improve the quality
of life of immunocompromized patients through providing information about effective antibiotic
treatment. The effects of different combinations of antibiotics were also analyzed in CLD
patients through evaluating the improvement in infectious disease. It was found during study that
combination of ceftriaxone and amikacin prove to be more effective in clinical settings but in
vitro studies shows the combination of cephradine with gentamycin was 97% susceptible.
Availability: Items available for loan: UVAS Library [Call number: 1841,T] (1).
53.
Evaluation Of Antimicrobial Therapy In Neonatal Sepsis
by Shazia Khanum | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Mr. Allah.
Material type: Book; Format:
print
; Literary form:
drama
Publisher: 2013Dissertation note: Background: Sepsis is the presence of bacteria in blood. Neonatal sepsis indicates bacterial blood stream infection (BSI), such as gastroenteritis meningitis, pyelonephritis, pneumonia which results in fever in neonates (Weber et al. 2003). This study was designed to check the bacteriology and sensitivity pattern of microbes causing sepsis in neonates. In this study microbial susceptibility testing against antibiotics and pattern of resistance of microbes in septic patients was determined. It was conducted on neonates suspected from sepsis in Sir Ganga Ram Hospital Lahore, Pakistan. Hypothesis: By using blood cultures and different biochemical tests bacterial etiological agents of neonatal sepsis were determined and their sensitivity pattern and empirical therapies were evaluated. Material & Methods: Blood samples were collected from septic neonates admitted in Sir Ganga Ram Hospital keeping all necessary aseptic precautions with the assistance of trained professionals. The pathogens were isolated, identified and purified by selective culturing methods, which were subjected to active growth, during which sensitivity to different antibiotics were checked. The sensitivity was measured by area marked by the zone of inhibition, and National Committee for Clinical Laboratory Standards (NCCLS). Standard limit was a key indicator towards resistant bacteria. Statistical Analysis: The collected data was analyzed by appropriate statistical procedure. Outcome: It was designed to isolate and identify the pathogens responsible for neonatal sepsis and to see the effects of different antibiotics regimens for treatment of neonatal sepsis by evaluating the improvement in clinical condition, rate of complications of disease and incidence of death due to this fatal disease.
Availability: Items available for loan: UVAS Library [Call number: 1843,T] (1).
54.
Comparative Mutagenic And Cytotoxic Evaluation Of Tamsulosin And Ciprofloxacin
by Faiza qamar | Dr. Muhammad Adil rasheed | Prof. Dr, Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1875,T] (1).
55.
Toxicological Evaluation Of Cetrimimide Chlorhexidin And Thiomersal Alone And In Combination
by Toseef Fatima Noshahi | Prof. Dr. Muhammad Ashraf | Dr.Imran Altaf | Dr.Muhammad Adil Rasheed.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1880,T] (1).
56.
Evaluation Of Cellular And Humoral Immune Responses Of Betamethasone In Mice
by Saima Batool | Dr. Aqeel javeed | Prof. Dr Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1881,T] (1).
57.
Comparative Mutagenic And Cytotoxic Evaluation Of Ibuprofen And Chloroquine
by Hunainah Khaliq | Dr. Adil rasheed | Prof Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2013Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1944,T] (1).
58.
Evaluation Of Immunomodulatory Activity Of Lornoxicam In Mice
by Zubaria malik | Dr.Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1945,T] (1).
59.
Evaluation Of Analgesic Anti-Inflammatory And Anti-Pyretic Activity Of Aqueous Methanolic Extract Of Jatropha Gossypifolia in Rats
by Mohsin Ahmad Ghauri | DR. Aqeel Javeed | Prof. Dr Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1988,T] (1).
60.
Genotoxic Mutagenic And Cytotoxic Potential Of Metformin And Celecoxib Alone And In Combination
by Asad ullah | Prof/ Dr. Muhammad Ashraf | Dr. Aqeel javeed | Prof. Dr. Aftab.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1989,T] (1).
61.
Protective Effect Of Vitamin A And E On The Toxicity Induced By The Hydroquinone
by Saima | Dr. MUhammad Adil rashid | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 1995,T] (1).
62.
Evaluation Of Immunomodulatory Activity Of Tenoxicam In Mice
by Fatima nasim | Dr. Aqeel javeed | Dr. Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2025,T] (1).
63.
Evaluation Of Antibacterial Activity Of Macrolides In Combination With Levamisole Hc1 Against Different Pathogenic Bacteria
by Sheeza javaid | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil rasheed | Proff. Dr. Aftab.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2026,T] (1).
64.
Bioequivalence Study Of Simvastatin In Healthy Human Volunteers
by Rana muhammad wasim shahzad | Dr. Muhammad adil rasheed | Prof. Dr. Muhammad ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2044,T] (1).
65.
Evaluation Of Antiviral And Cytotoxic Activity Of Parthenium Hysterophorusagainst Peste Des Petits
by Aina asghar | Dr. Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2051,T] (1).
66.
Effect Of Calcium Hypochlorite And Chloramine On Blood Biochemistry And Sodium Pentobarbital Induced Sleeping
by Sidra ishaq | Dr. Muhammad Adil rasheed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2062,T] (1).
67.
Effect Of Gemifloxacin On Cellular And Humoral Immune Response In Mice
by Muhammad Umair | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2088,T] (1).
68.
Toxicity And Immunomodulatory Activity Of Ketoprofen In Vitro And In Vivo
by Dawood Ahmad Hamdani | Dr. Aqeel javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2090,T] (1).
69.
Evaluation Of Antihistaminic And Anticholinergic Activity Of Aqueous And Alcoholic Extracts Of Equisetum Debile
by Shahrukh Ali | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2097,T] (1).
70.
Evaluation Of Antihistaminic And Anticholinergic Activity Of Aqueous And Alcoholic Extracts Of Piper Betel And Murraya Koenigii Plants
by Hassan Mahmood Qureshi | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2098,T] (1).
71.
Cytotoxicity & Antiviral Profile Of Equisetum Debile (Bansi Booti) Against Food And Mouth Disease Virus In -Vitro Cell Culture
by Naeem Rasool | Dr. Muhammad Ovais omer | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2105,T] (1).
72.
Antibacterial And Cytotoxic Evaluation Of Aqueous Ethanolic And Chlorooform Extracts Of Parthenium Hysterophorus
by Sidrah Shoaib | Dr. Muhammad Adil Rasheed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2109,T] (1).
73.
Synergistic Effect Of Antimicrobial Agents In Combination With Colistin Against Bacterial Isolates From Patients
by Sahar Safdar | Prof. Dr. Muhammad Ashraf | Dr. Muhammad Adil Rasheed | Prof. Dr. Aftab.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2123,T] (1).
74.
Evaluation Of Immunomodulatory Activity Of Aceclofenac In Mice
by Hammad Asif | Dr. Aqeel Javeed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2125,T] (1).
75.
A New Inclination Of Derived Tetrahydro-Carbazole Towards Anti-Inflammatory Analgesic And Antipyretic Activity
by Kinza Kanwal | Prof. Dr. Muhammad Ashraf | Dr. Aqeel Javeed | Mr. Malik Allah.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2136,T] (1).
76.
Evaluation Of Mutagenicity And Genotoxicity Of Furosemide And Propranolol Alone And In Combination Using Ames Test And Single Cell Gel Electrophoresis (Comet) Assay
by Sadaf Naz | Dr. Muhammad Adil rasheed | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2158,T] (1).
77.
Efficacy Of Cephalosporins Alone And In Combination With Zinc Sulphate In Tients With Post Surgical Infection
by Maria Naeem | Dr. Muhammad Ovais Omer | Prof. Dr. Muhammad Ashraf.
Material type: Book; Format:
print
; Literary form:
not fiction
Publisher: 2014Dissertation note: Abstract Availability: Items available for loan: UVAS Library [Call number: 2166,T] (1).