Effects Of Infectious Bursal Desease Vaccine And Vaccination Schedule In Imunity Induceds By Newcastle Disease
By: Kashif-ur-Rehman
| Prof.Dr.Mansur-ud-Din Ahmad.
Contributor(s): Dr.Imran Najeeb | Prof.Dr.Azhar Maqbool | Faculty of Veterinary Sciences.
Material type: 
BookPublisher: 2008Subject(s): Department of MicrobiologyDDC classification: 1017,T Dissertation note: The study was carried out for verifying the interference of infectious bursal
disease vaccines conmonly used in Pakistan on the immunity to Newcastle disease vaccines. Infectious bursal disease (IBD) is a viral disease producing suppression in humoral immune response causing degeneration of bursa of Fabricius. Different vaccines are available in the market for mass scale immunization of chickens. The study was carried out to compare the immunosuppressive effects of intermediate strain, hot strain and complex IBDV vaccines on immunity induced by NDV vaccine. Vaccine efficacy was studied by measuring the induced humoral antibody level using HI (Haemagglutination inhibition) test for NDV and indirect ELISA (enzyme-linked immunosorbent assay) (Kirkegaard' & Perry Laboratories - KPL) to detect antibodies against IBDV.
The parameters used to evaluate the effects of IBDV vaccine on broiler chicks were immune response to NDV vaccination, weight of lymphoid organs such as bursa of Fabricius, thymus and spleen, post virulent NDV challenge and FCR. The results showed that IBDV vaccinated groups A, B, C, D and E had lower HI antibody profile, higher bursa, spleen and thymus body weight ratio, poor FCR and higher post challenge mortality than NDV vaccinated group F. The HI serum antibody profile revealed that the groups vaccinated with IBDV hot strain had significantly lower antibody titer as compared to the intermediate strain of IBDV vaccinated birds. In addition to that hot strain vaccine found to be more damaging to the bursa, spleen and thymus than the intermediate strain vaccine. The hot strain had adverse effects on the feed conversion ratio of birds as well. The challenge with virulent NDV revealed that IBDV vaccine treated groups were overall higher mortality than the only NDV vaccinated chickens.
The study suggested the use of intermediate strain as vaccine since it had least interference with the antibody production against ND. However, hot strain used in this study had adversely affected the NDV HI. titer and caused more damage to the lymphoid organs and reduced feed conversion ratio (FCR).
| Item type | Current location | Collection | Call number | Status | Date due | Barcode | Item holds |
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 1017,T (Browse shelf) | Available | 1017,T |
The study was carried out for verifying the interference of infectious bursal
disease vaccines conmonly used in Pakistan on the immunity to Newcastle disease vaccines. Infectious bursal disease (IBD) is a viral disease producing suppression in humoral immune response causing degeneration of bursa of Fabricius. Different vaccines are available in the market for mass scale immunization of chickens. The study was carried out to compare the immunosuppressive effects of intermediate strain, hot strain and complex IBDV vaccines on immunity induced by NDV vaccine. Vaccine efficacy was studied by measuring the induced humoral antibody level using HI (Haemagglutination inhibition) test for NDV and indirect ELISA (enzyme-linked immunosorbent assay) (Kirkegaard' & Perry Laboratories - KPL) to detect antibodies against IBDV.
The parameters used to evaluate the effects of IBDV vaccine on broiler chicks were immune response to NDV vaccination, weight of lymphoid organs such as bursa of Fabricius, thymus and spleen, post virulent NDV challenge and FCR. The results showed that IBDV vaccinated groups A, B, C, D and E had lower HI antibody profile, higher bursa, spleen and thymus body weight ratio, poor FCR and higher post challenge mortality than NDV vaccinated group F. The HI serum antibody profile revealed that the groups vaccinated with IBDV hot strain had significantly lower antibody titer as compared to the intermediate strain of IBDV vaccinated birds. In addition to that hot strain vaccine found to be more damaging to the bursa, spleen and thymus than the intermediate strain vaccine. The hot strain had adverse effects on the feed conversion ratio of birds as well. The challenge with virulent NDV revealed that IBDV vaccine treated groups were overall higher mortality than the only NDV vaccinated chickens.
The study suggested the use of intermediate strain as vaccine since it had least interference with the antibody production against ND. However, hot strain used in this study had adversely affected the NDV HI. titer and caused more damage to the lymphoid organs and reduced feed conversion ratio (FCR).
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