Detection And Control Of Vaccination Stress Following Vaccination With Live Virus Newcastle Disease Vaccine And Its Effect on Immune Response Commmercial Broiler Chicks
Material type: Book ; Format:
Publisher: 1997 Dissertation note: This study intended to ascertain the vaccination stress following live Newcastle disease vaccine by oral route and to determine the comparative efficacy of probiotic and vitamins to combat it. One hundred and forty day-old broiler chicks were divided into four groups i.e. A, B, C and D having 35 birds each. The birds were kept for 45 days alter vaccination with Bio-LaSota by oral route on 21st day. Chicks From group A was kept as control. Group B was given vaccine and no treatment. Group C was given vaccine and only brobiotic (protexin). Group D was given vaccine and only vitamins (Vitaoligosol). Seven birds of each group were slaughtered on 22nd day, 23th, 24th and 25th day and remaining 7 birds of each group were slaughtered on day 45th, for collection of blood samples. The blood samples from 7 randomly selected birds were collected on day 16, 30th and day 45th for determination of antibody t.itre. The following parameters were studied: (i) determination of hetrophil/lymphocyte ratio (Ii) estimation of antibody response against Newcastle disease vaccine (iii) estimation of serum biochemical substances (iv) Determination of adrenal gland body weight index and (v) Pathological study of adrenal glands. Live virus vaccine against Newcastle disease caused vaccination stress in broiler chickcns. The birds expressed vaccination stress for a variable period ranged from 1 to 2 post-vaccination day. But these results were more accurate if level of corticosteroids was detected. In future, a more comprehensive study is required to devise simple and reliable methods for detecting stress in poultry in field conditions and also to suggest therapeutic and prophylactic measures for relieving the birds from the state of stress.
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Immuno Pathological Effects Of Neem (Azadirachta Indica) In Commercial Broiler Chickens
Material type: Book ; Format:
; Literary form:
Publisher: 2012 Dissertation note: These experiments were conducted to study the effects of Azadirachta indica admixed in poultry feed on weight gain performance, haemtological values,immune modulations, and toxic effects in broiler chickens. A total number of 144 commercial broiler 1-day old chicks were reared in the experimental sheds of the Department of Pathology, University of Veterinary & Animal Sciences, Lahore, The birds were fed with balanced commercial feed and water ad libitum. The birds were divided into 3 groups; A, B and C having fourty eight chicks each. Birds of all groups were sub divided into four groups of each i.e. A1, A2, A3 and A4; B1, B2, B3 & B4 and C1, C2, C3 and C4, respectively. Each of the sub groups containd 12 birds. Sub groups A4, B4 and C4 were control group with no medication. The birds of groups A, B and C were fed with poultry feed containing dry powder of neem leaves @ 2 gm, 4 gm and 6gm per kg of feed respectively. The birds of groups A1, B1 and C1 were treated with the herb from day 0 to 42 of their life. The birds of groups A2, B2 and C2 were given the neem from day 14 to 42 of their life, whereas the birds of groups A3, B3 and C3 were treated with the herb from day 28 to 42 of their life. Difference between weekly weight gain in the birds of groups A1, B1 and C1 was non significant (P>0.05) however the difference between weight gain in the treated and control groups was significant (P<0.05). The birds treated with the herb from day 0 of their life showed more weight gain. There was no difference in the haematological indices between all of the treated groups and the control groups. The neem treated birds showed increased antibody titers against ND and IBD viruses as compared to control groups. The values of ALP and ASTshowed decreasing trend when the level of neem leaf meal was increased in the ration. Serum creatinine and serum uric acid values posed a slight declining trend in the neem fed birds. There was a decrease in serum cholesterol level in the neem treated bird groups, the higher the concentreation of the herb, the lower the cholesterol value. The organ body weight indices showed that there was no significant difference in liver, spleen and thymus weights among treated groups as well between treated and control groups. There was absence of prominent gross pathological lesions in liver, spleen, kidneys and thymus, however some treated groups showed mild hypertrophied liver and kidneys as did the organs of the birds in control groups. No histopathological changes except a few mild changes were observed in liver, spleen, kidneys and thymus in the birds of experimental groups.
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