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1. Effect Of Unilateral And Bilateral Thyroidectomy On Hormonal And Biochemical Parameters In Dogs

by Mehmood Ur Rehman (2009-VA-177) | Dr. Hamid Akbar | Prof. Dr.M.Arif Khan | Dr. Muti ur Rehman Khan.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: Thyroid gland is one of the most important endocrine gland of animal body. T3 and T4 are two major hormones secreted by thyroid gland. These hormones have a major role in metabolism of cells and organs. In normal thyroid both these hormones have anabolic effect. Thyroid tumors account for 1.2-3.8 % of all types of tumors in dogs. Unilateral, bilateral or subtotal thyroidectomies are practiced to remove benign or malignant thyroid carcinomas. The present study was conducted on 12 mongrel dogs. These dogs were rendered to 3 groups with 4 dogs in each group. One group acted as control, in which no surgery was performed, second group underwent unilateral removal of thyroid gland while the third group underwent bilateral removal of thyroid gland. Free thyroxine, thyroid stimulating hormone level, calcium, W.B.Cs, R.B.Cs and haemoglobin concentration were monitored for 21 days post-operatively. The data was expressed as mean and standard deviation. Results of the study were analysed by 2 samples T-test, one way ANOVA using multiple comparison test on SPSS version 16.0. Based on these results it was concluded that bilateral thyroidectomy was effective in relieving hyperthyroidism but there is a need to immediately initiate levothyroxine therapy. Free T4 level drops near to zero by day 21 and TSH level rises by many folds. On the other hand, in unilateral procedure Free T4 level remain in normal range and 75% of dogs require no levothyroxine therapy. Level of calcium in unilateral and bilateral thyroid removal remains within normal range provided parathyroid glands are preserved properly. Haemoglobin concentration in both the procedures is reduced significantly postoperatively. There is a need to monitor blood parameters postoperatively. Availability: Items available for loan: UVAS Library [Call number: 2657-T] (1).

2. A Clinico-Biochemical Study On Different Pre-Anesthetic Drugs With Propofol For Neutering In Dogs

by Saba Siddique | Dr. Sadaf Aslam | Prof. Dr.M.Arif Khan | Dr. Raheela Akhtar.

Material type: book Book; Literary form: not fiction Publisher: 2016Dissertation note: The present research project was designed to study the effect of three routinely used pre anaesthetic (alpha-2 adrenergic agonists) drugs xylazine (xylaz; 20 mg/ml, farvet, Holland) and medetomidine (doiter, 1 mg/ml ; Orion pharma, finland), diazepam(Valium 0.25 mg/kg) and propofol (pofol, 10 mg/ml ;Dongkook pharma, korea) anaesthesia in male dogs and castration surgery was performed using pre scrotal approach. The effect of these sedative and anaesthetic agents was studied at physical (temperature, pulse, and respiration), sedative (palpebral effect), analgesic (tail pinch, toe pinch reflex), liver function (ALT, AST, and ALP), renal functions (serum creatinine, BUN) and haematological (RBC, WBC, Hb) parameters. A total number of twelve (12) dogs (mix breed) clinical cases were selected. These dogs were subjected into three groups (A, B , C) each comprising four (4) dogs. Different drugs combination was administered in each group of dogs. Three different drug combinations are; Group A .Xylazine-Propofol Group B. Diazepam-Propofol Group C. Medetomidine-Propofol Blood samples were taken at four different intervals like 0 minutes, 30 minutes, 60 minutes and after 24 hours in EDTA coated vacutainer for studying haematological parameters and in lithium heparin vacutainer for evaluating biochemical parameters. Results revealed that both sedative and anaesthetic agents produce slight non-significant changes in liver enzymes but in case of renal function test, medetomidine-propofol produce significant Summary 42 changes in serum creatinine and xylazine-propofol, and diazepam-propofol produce significant changes in the values of blood urea nitrogen. Coming towards haematology, white blood cells increase significantly in diazepam-propofol receiving group. The results of the present research study were mostly similar with the findings of other scientists. The results of present project were analysed by ANOVA followed by Turkey honestly significant difference (HSD) test. Conclusion The result of present project will prove fruitful for veterinary practioners for selectin anaesthesia protocol for patients suffering from hepatitis or other liver, renal and haematological problems and would be productive to solve the problems of anaesthetists who are actively engaged in canine practice all over the world. On the basis of findings of this study it is concluded that medetomidine-propofol combination gives better results. Availability: Items available for loan: UVAS Library [Call number: 2689-T] (1).

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