Comparative Efficacy Of Pre And Post Exposure Prophylaxis Using Indigenous Rabies Vaccine By Im Route
By: Kaneez Fatima (2010-VA-202)
| Prof. Dr. Tahir Yaqub.
Contributor(s): Dr. Aamir Ghafoor Bajwa | Dr. Maryam Javed.
Material type: 
BookPublisher: 2017Description: 46p.Subject(s): MicrobiologyDDC classification: 2875-T Dissertation note: Rabies is a viral zoonosis that is known to be present in more than 150 countries, including Pakistan. It is a very serious health problem especially in countries with limited resources and poor awareness. It has significant economic impact and almost 100 % mortality if not properly managed.Dogs are responsible for up to 99% of all rabies transmissions to humans. Rabies is vaccine preventable viral disease. The vaccine is very expensive and a significant factor in patient’s compliance in Pakistan especially in rural areas where the main problem exist i.e. more stray dogs and increased probability of being bitten. Availability of a cheap indigenously produced effective vaccine can be very helpful in reducing the cost and overall improvement of the rabies problem in Pakistan.
We randomly selected a total of 50 patients visiting IPH. Among them 10 of pre-exposure prophylaxis and 40 for post-exposure prophylaxis. Twenty patients of the post-exposure group were children and twenty were adults. The NIH-anti rabies vaccine was administered intramuscularly to the persons visiting the IPH for pre and post exposure prophylaxis using Essen regimen. For pre exposure patients three doses on day 0,7,28 was given and for post exposure patients five doses on day 0, 3, 7, 14, and 28 was administered. The 3ml blood was collected on day 0, 28, 60 and 90 following vaccination. Serum was examined by ELISA Kit (Bio Rad Platelia rabies II Kit) for protective antibody titer.
Pakistan is importing anti-rabies vaccine which is much costly, and sometimes unavailability is a serious concern for patients. In the present study we concluded that indigenous rabies vaccine was very effective and protective levels of rabies antibody titers was detected following vaccination in all patients of the study. By widespread utilization of this vaccine we can reduce demand of imported vaccine, thus lessen the economic burden.
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2875-T (Browse shelf) | Available | 2875-T |
Rabies is a viral zoonosis that is known to be present in more than 150 countries, including Pakistan. It is a very serious health problem especially in countries with limited resources and poor awareness. It has significant economic impact and almost 100 % mortality if not properly managed.Dogs are responsible for up to 99% of all rabies transmissions to humans. Rabies is vaccine preventable viral disease. The vaccine is very expensive and a significant factor in patient’s compliance in Pakistan especially in rural areas where the main problem exist i.e. more stray dogs and increased probability of being bitten. Availability of a cheap indigenously produced effective vaccine can be very helpful in reducing the cost and overall improvement of the rabies problem in Pakistan.
We randomly selected a total of 50 patients visiting IPH. Among them 10 of pre-exposure prophylaxis and 40 for post-exposure prophylaxis. Twenty patients of the post-exposure group were children and twenty were adults. The NIH-anti rabies vaccine was administered intramuscularly to the persons visiting the IPH for pre and post exposure prophylaxis using Essen regimen. For pre exposure patients three doses on day 0,7,28 was given and for post exposure patients five doses on day 0, 3, 7, 14, and 28 was administered. The 3ml blood was collected on day 0, 28, 60 and 90 following vaccination. Serum was examined by ELISA Kit (Bio Rad Platelia rabies II Kit) for protective antibody titer.
Pakistan is importing anti-rabies vaccine which is much costly, and sometimes unavailability is a serious concern for patients. In the present study we concluded that indigenous rabies vaccine was very effective and protective levels of rabies antibody titers was detected following vaccination in all patients of the study. By widespread utilization of this vaccine we can reduce demand of imported vaccine, thus lessen the economic burden.
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