000 02423nam a22002177a 4500
005 20170302085650.0
008 170302b2016 xxu||||| |||| 00| 0 eng d
041 _aeng
082 _a2657-T
100 _aMehmood Ur Rehman (2009-VA-177)
_929449
110 _cDr. Hamid Akbar
_923944
245 _aEffect Of Unilateral And Bilateral Thyroidectomy On Hormonal And Biochemical Parameters In Dogs
260 _c2016.
300 _a57p.;
502 _aThyroid gland is one of the most important endocrine gland of animal body. T3 and T4 are two major hormones secreted by thyroid gland. These hormones have a major role in metabolism of cells and organs. In normal thyroid both these hormones have anabolic effect. Thyroid tumors account for 1.2-3.8 % of all types of tumors in dogs. Unilateral, bilateral or subtotal thyroidectomies are practiced to remove benign or malignant thyroid carcinomas. The present study was conducted on 12 mongrel dogs. These dogs were rendered to 3 groups with 4 dogs in each group. One group acted as control, in which no surgery was performed, second group underwent unilateral removal of thyroid gland while the third group underwent bilateral removal of thyroid gland. Free thyroxine, thyroid stimulating hormone level, calcium, W.B.Cs, R.B.Cs and haemoglobin concentration were monitored for 21 days post-operatively. The data was expressed as mean and standard deviation. Results of the study were analysed by 2 samples T-test, one way ANOVA using multiple comparison test on SPSS version 16.0. Based on these results it was concluded that bilateral thyroidectomy was effective in relieving hyperthyroidism but there is a need to immediately initiate levothyroxine therapy. Free T4 level drops near to zero by day 21 and TSH level rises by many folds. On the other hand, in unilateral procedure Free T4 level remain in normal range and 75% of dogs require no levothyroxine therapy. Level of calcium in unilateral and bilateral thyroid removal remains within normal range provided parathyroid glands are preserved properly. Haemoglobin concentration in both the procedures is reduced significantly postoperatively. There is a need to monitor blood parameters postoperatively.
650 _aVeterinary Surgery
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650 _aCMS--Clinical Medicine and Surgery
_921932
700 _aProf. Dr.M.Arif Khan
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700 _aDr. Muti ur Rehman Khan
_95983
942 _cTH
999 _c10604
_d10603