000 03107nam a22002177a 4500
005 20170403100747.0
008 170403b2016 xxu||||| |||| 00| 0 eng d
041 _aeng
082 _a2689-T
100 _aSaba Siddique
_929878
110 _cDr. Sadaf Aslam
_914926
245 _aA Clinico-Biochemical Study On Different Pre-Anesthetic Drugs With Propofol For Neutering In Dogs
260 _c2016.
300 _a45p.;
502 _aThe present research project was designed to study the effect of three routinely used pre anaesthetic (alpha-2 adrenergic agonists) drugs xylazine (xylaz; 20 mg/ml, farvet, Holland) and medetomidine (doiter, 1 mg/ml ; Orion pharma, finland), diazepam(Valium 0.25 mg/kg) and propofol (pofol, 10 mg/ml ;Dongkook pharma, korea) anaesthesia in male dogs and castration surgery was performed using pre scrotal approach. The effect of these sedative and anaesthetic agents was studied at physical (temperature, pulse, and respiration), sedative (palpebral effect), analgesic (tail pinch, toe pinch reflex), liver function (ALT, AST, and ALP), renal functions (serum creatinine, BUN) and haematological (RBC, WBC, Hb) parameters. A total number of twelve (12) dogs (mix breed) clinical cases were selected. These dogs were subjected into three groups (A, B , C) each comprising four (4) dogs. Different drugs combination was administered in each group of dogs. Three different drug combinations are; Group A .Xylazine-Propofol Group B. Diazepam-Propofol Group C. Medetomidine-Propofol Blood samples were taken at four different intervals like 0 minutes, 30 minutes, 60 minutes and after 24 hours in EDTA coated vacutainer for studying haematological parameters and in lithium heparin vacutainer for evaluating biochemical parameters. Results revealed that both sedative and anaesthetic agents produce slight non-significant changes in liver enzymes but in case of renal function test, medetomidine-propofol produce significant Summary 42 changes in serum creatinine and xylazine-propofol, and diazepam-propofol produce significant changes in the values of blood urea nitrogen. Coming towards haematology, white blood cells increase significantly in diazepam-propofol receiving group. The results of the present research study were mostly similar with the findings of other scientists. The results of present project were analysed by ANOVA followed by Turkey honestly significant difference (HSD) test. Conclusion The result of present project will prove fruitful for veterinary practioners for selectin anaesthesia protocol for patients suffering from hepatitis or other liver, renal and haematological problems and would be productive to solve the problems of anaesthetists who are actively engaged in canine practice all over the world. On the basis of findings of this study it is concluded that medetomidine-propofol combination gives better results.
650 _aSurgery
_929879
650 _aCMS--Clinical Medicine and Surgery
_921932
700 _aProf. Dr.M.Arif Khan
_929451
700 _aDr. Raheela Akhtar
_94945
942 _cTH
999 _c10799
_d10798