000			01681nam a2200217 a 4500
020			_a0521836549 (hardcover)
020			_a9780521836548 (hardcover)
082			_a572.8 Henderson 17928 1st 2005 Genetics
100			_aHenderson, Brian. _96771
245	1	0	_aMolecular Chaperones And Cell Signalling
250			_a1st ed.
260			_aUSA: _bCambridge University Press, _c2005.
300			_a344 p. ;
520			_aOriginally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
650			_aCellular signal transduction _96772
650			_aProtein folding _92830
650			_aCellular signal transduction _96773
700	1		_aHenderson, Brian. _96774
700	1		_aPockley, A. Graham. _92833
942			_cBK
999			_c1249 _d1249