000 | 02202nam a2200241 a 4500 | ||
---|---|---|---|
020 | _a1402037635 (hardcover) | ||
020 | _a9781402037634 (hardcover) | ||
082 | _a614.5999 Nigg 27639 V.570,1st 2005 Genetics | ||
100 |
_aNigg, Erich A. _93422 |
||
245 | 1 | 0 | _aGenome Instability in Cancer Development |
250 | _a2005th ed. | ||
260 |
_aNetherlands, : _bSpringer, _c2005. |
||
300 | _a512 p. ; | ||
490 | 1 | _aAdvances in experimental medicine and biology. | |
520 | _aResearch over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke | ||
650 |
_aCancer--Genetic aspects _93423 |
||
650 |
_aGenomics _97309 |
||
650 |
_aMedicine _93424 |
||
650 |
_aOncology _93425 |
||
650 |
_aLife sciences _92186 |
||
650 |
_aTumors--Etiology _93426 |
||
942 | _cBK | ||
999 |
_c1443 _d1443 |