000 01625nam a2200205 a 4500
020 _a0792373359 (hardcover)
020 _a9780792373353 (hardcover)
082 _a572.555 Hatfield 20126 1st 2001 Genetics
100 _aHatfield, Dolph L.
245 1 0 _aSelenium : Its Molecular Biology and Role in Human Health
250 _a1st ed.
260 _aUK:
300 _a352 p. ;
520 _aAs discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.
650 _aSelenium--Physiological effect
650 _aSelenium--Health aspects
650 _aSelenium in human nutrition
650 _aLife sciences
942 _cBK
999 _c1541