000			01625nam a2200205 a 4500
020			_a0792373359 (hardcover)
020			_a9780792373353 (hardcover)
082			_a572.555 Hatfield 20126 1st 2001 Genetics
100			_aHatfield, Dolph L. _93649
245	1	0	_aSelenium : Its Molecular Biology and Role in Human Health
250			_a1st ed.
260			_aUK: _bSpringer, _c2001.
300			_a352 p. ;
520			_aAs discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.
650			_aSelenium--Physiological effect _93650
650			_aSelenium--Health aspects _93651
650			_aSelenium in human nutrition _93652
650			_aLife sciences _92186
942			_cBK
999			_c1541 _d1541