000			02192nam a2200169 a 4500
020			_a1588291871 (hardcover)
020			_a9781588291875 (hardcover)
082			_a611.01816 Peltz 20007 1st 2005 Genetics
245	1	0	_aComputational Genetics And AGenomics: Tools for Understanding Disease
250			_a1st
260			_aU.S.A: _bHumana Press; _c2005.
300			_a308 p. ;
520			_aUltimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial.
650			_aGenetics _aGenomics-Mathematical models _aMedicine _aHuman genetics _aGenomics _97506
700	1		_aPeltz, Gary. (Editor) _94026
942			_cBK
999			_c1683 _d1683