000			02170nam a2200205Ia 4500
005			20150921132735.0
008			150525s2002 xx 000 0 und d
041			_aeng
082			_a0756,T
100			_aRahat Munir Chaudhry _96951
110			_cDr. Shakil Akhtar Khan _95319
245			_aEffects Of Lincomycin And Spectinomycin Combination On The Immune Response Of Newcastle Disease Virus Vacinated
260			_c2002
502			_aThe project was designed to observe the effects of Lincospectin on the immune system of broiler chicks. Chicks divided in groups A, B and C were offered Lincospectin at 225mg/kg; 450mg/kg and 112.5 mg/kg body weight levels, respectively. All the chicks in various treatment groups were reared upto day 42 and the effects of Lincospectin on organ body weight indices, gross lesions on liver, spleen, thyrnus and bursa of Fabricius, and immune response of chicks against Newcastle Disease Virus vaccination, were determined. The organ body weight indices of spleen, thymus and bursa of Fabricius and liver did not indicate significant differences (P>0.05) amongst the Lincospectin treated and untreated groups. However, the bursal body weight ratio of chicks in groups A, B and C at day 7 were significantly higher than those of group D. The data obtained on the analysis of HI antibody titre against Newcastle Disease Virus on days 1,7,14, 21, 28, 35 and 42 indicated that the geometric mean HI titres of Lincospectin treated groups (A, B and C) were quite different from each other and the chicks of group A had the best sero conversion. It was concluded that over all group A had the best immune response against NDV vaccination. This study indicates that Lincospectin at a dose rate of 225mg/kg body weight did not interfere in the immune response of chicks to NDV, helped in better wiehgt gains upto day 42 and did not cause any gross or histopathological lesions in the organs like thymus, bursa of Fabricius, spleen or liver.
650			_aDepartment of Pathology _94635
700			_aDr. Asim Aslam _95682
700			_aDr. Khalid Saeed _96387
710			_aFaculty of Veterinary Sciences _94292
942			_cTH
999			_c2492 _d2492