000			01982nam a2200193Ia 4500
005			20150921152304.0
008			150525s2005 xx 000 0 und d
041			_aeng
082			_a0882,T
100			_aAli Ahmed Malik _97192
110			_cProf. Dr. Masood Babbani _97193
245			_aPassive Immunization Against Canine Distermper Virus In Dogs
260			_c2005
502			_a Canine distemper is an important, highly contagious disease of dogs, caused by morbillivirus of family paramyxoviridae. The disease occurs worldwide in variety of hosts. In the present study, data relative to breed, sex and age susceptibility in clinically suspected cases of canine distemper was collected and analyzed. The disease is mostly seen in young nonvaccinated dogs of 4 to 6 months of age when maternal anti-CDV antibodies are decreased. Immune serum was raised in experimental dogs with commercially available measles live virus vaccine. The level of antibodies in the immune serum was determined by agar gel precipitation test (AGPT) and an ELISA based assay. Immune serum containing 128 AGPT units of anti-CDV antibodies was effective to control the disease in infected dogs after natural exposure to canine distemper virus. Finally the effective time for passive immunization against canine distemper was determined in experimental dogs. It was noted that immune serum offered protection to canine distemper immediately after infection, during the incubation period of the disease , 48 hours after infection and early phase of the disease(at the appearance of clinical signs). Passive immunization is not rewarding in the terminal phase of the disease (when infected dogs show nervous signs of the disease).Thus it is very useful for the prevention of disease in dogs kept with infected dogs in kennels and pet shops.
650			_aDepartment of Microbiology _94609
700			_aProf. Dr. Khushi Muhammad _916216
710			_aFaculty of Veterinary Sciences _94292
942			_cTH
999			_c2610 _d2610