000 01467nam a2200181Ia 4500
005 20151001150040.0
008 150525s2010 xx 000 0 und d
041 _aeng
082 _a1223,T
100 _aMuneer Ahmad
_96827
110 _cMr. Tanveer Hussain
_96615
245 _aGenetic Study Of Ushic/Dfnb18 By Linkage Analysis
260 _c2010
502 _aDeafness refers to conditions in which individuals are fully or partially unable to detect or perceive at least some frequencies of sound which can typically be heard by members of their species. In human beings, the term hearing impairment is usually reserved for people who have relative insensitivity to sound in the speech frequencies. In the present study, six families were identified which were collected from FATA, Lahore and Sheikhupura and were consist of at least two deaf people. Pedigrees of the affected families were drawn using Cyrillic software. Blood samples were collected from these families. DNA was extracted through Inorganic protocol. The creening of the affected families was done for known deafness locus, USH1C/ DFNBI8. Then the PAGE (Polyacrylamide Gel Eletrophoresis) was done and haplotypes were constructed to determine whether a family was linked to deafness locus or not. Out of six families, no family was linked to USHIC/ DFNB18 locus.
650 _aInstitute of Biochemistry & Biotechnology
_95022
700 _aProf. Dr. Masroor Elahi Babar
_96616
942 _cTH
999 _c2942
_d2942