000 02061nam a2200193Ia 4500
005 20151005140951.0
008 150525s2011 xx 000 0 und d
041 _aeng
082 _a1329,T
100 _aFarah Abid
110 _cProf.Dr.Muhammad Ashraf
245 _aComparative Pharmacokinetics Of Silymarin In Healthy Male And Female Volunteers
260 _c2011
502 _aThe study was designed to compare the pharmacokinetic parameters of Silymarin in 8 healthy male and 8 healthy female volunteers. Only those healthy volunteers were selected who were of age between 18-45 years, not having any disease. Female's volunteers were also of age of 18-45 years and also who were not pregnant and also not suffering from any disease. Written consent form were taken from the volunteer and they were thoroughly inform about the study and objectives of study ,frequency of blood sampling, and any other side effects linked to the drug which they might having during the study. Volunteers were divided into two groups A and B respectively. Both groups were given silymarin 200mg dose per oral to each individua1.5ml of blood samples were drawn after different time interval .5 ,1,2,3,5,8 and 12 hr from the vein through 5ml BD syringes of 22 gauge needle after oral administration of silymarin. Plasma were separated by centrifugation at 5000 RPM and stored at -40 C till analysis. Silymarin concentration in plasma was determined by using HPLC method. All pharmacokinetics parameter were determined by entering the plasma concentration time data in software APO pharmacological analysis .Then pharmacological parameters in healthy male and healthy females were compared. Result showed that pharmacokinetic parameters are significant & those parameters were AVC, Tmax, t1l2 & CI. This result showed that there is a significant relationship between healthy male & female.
650 _aDepartment of Pharmaoclogy & Toxicology
700 _aDr. Mateen
700 _aDr. Sualeha Riffat
942 _cTH
999 _c3045