| 000 | 02397nam a2200241 a 4500 | ||
|---|---|---|---|
| 008 | 151228s2006 xxu eng d | ||
| 020 | _a9241209399 (paperback) | ||
| 020 | _a9789241209397 (paperback) | ||
| 082 | _a615.954 WHO 19478 1st 2006 Pharmacology | ||
| 100 | 1 |
_aWorld Health Organization _938912 |
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| 245 | 1 | 0 | _aJoint FAO/WHO Expert Committee on Food Additives; Food and Agriculture Organization of the United Nations; Joint FAO/WHO Expert Committee on Food Additives |
| 260 |
_aSingapore: _bWorld Health Organization, _c2006. |
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| 300 | _a86 p. ; | ||
| 490 | 1 | _aWho Technical Report Series | |
| 520 | _aThis report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of JECFA, including compounds without an ADI or MRL; recommendations on principles and methods in derivation of MRLs, including a new procedure for estimating chronic dietary intakes; the use of a spreadsheet-based procedure for the statistical evaluation of residue depletion data; a revised approach for the derivation of microbiological ADIs; and the Committee's review of and comments on documents provided by the Codex Committee on Residues of Veterinary Drugs. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (colistin, erythromycin, flumequine), two production aids (melengestrol acetate, ractopamine hydrochloride, an insecticide (trichlorfon (metrifonate)), and an anthelminthic (triclabendazole). In addition, the attempt by the Committee to use tylosin as an example to investigate if evaluations are possible based on published data in the absence of data submissions from sponsors is described. Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits. | ||
| 650 |
_aVeterinary drug residues _938913 |
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| 650 |
_aPharmacology _938914 |
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| 650 |
_aVeterinary drugs _938915 |
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| 650 |
_aFood additives _938916 |
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| 650 |
_aFood contamination _938917 |
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| 650 |
_aFood Science and Human nutrition _938918 |
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| 942 | _cBK | ||
| 999 |
_c6859 _d6858 |
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