000			03125nam a22002057a 4500
005			20160726101059.0
008			160726b2016 xxu||||| |||| 00| 0 eng d
041			_aeng
082			_a2492-T
100			_aSuliman (2014-VA-494) _924955
110			_cDr. Khalid Abdul Majeed _921921
245			_aEffect Of Sub-Chronic Exposure Of Bisphenola On Serum Minrals And Bone Health In Rats
260			_c2016.
300			_a39p.;
502			_aEndocrine disruptors (EDs) are exogenous compounds present worldwide. Endocrine hormone production, release, transport, binding, action or elimination is enhanced or interrupted by EDs and hence affect homeostasis, development, reproduction and behaviour of organisms. Bisphenol A (BPA) is one of the most important EDs used extensively in consumer products such as beverage, food can lining, dental sealants and thermal paper and water pipes. BPA binds to estrogen receptors and enhance or interrupt the endocrine system. BPA have negative effectson bone health and serum minerals in rats. A total of 48 adult rats were divided in three main groups i.e. (16 rats in each group). Each group was sub-divided into male (8 rats) and female (8rats). Control Group: Basal rat diet was provided to control group. Group A: BPA 1mg/kg body weight daily along with basal rat diet was given to group A. BPA was dissolved in 10 % ethanol and was diluted with distilled water. Group B: BPA 0.1mg/kg body weight daily along with basal rat diet was given to Group B. BPA was dissolved in 10 % ethanol and was diluted with distilled water. Trial duration was 3 months and at the end rats were killed to obtain the bones and muscles to observe their bone characteristics (bone length, width, and medullary canal diameter) and serum minerals (Zn, Fe, Cu and Ca) analysis.Data wasanalysed using two ways ANOVA through SPSS version (SPSS Inc. version 20, Chicago, Illinois) and was presented as mean± SEM. Femur bone length was found to be significantly higher in male rats treated with BPA 0.1mg/kg and 1mg/kg compared to control. The femur bone length was not affected in female rats. Rest of the parameters in bone health of tibia and femur were not affected by treatment. Bone minerals (Ca, Cu, Fe, and Zn) were also not affected by the treatment irrespective of treatments.Serum calcium was significantly higher in mal rates treated with 1mg/kg BPA compared to control; whereas it decreased significantly in female rats treated with 1mg/kg BPA compared to control. Serum zinc concentrations also decreased significantly in female rats treated with BPA 1mg/kg compared to control. Muscle copper concentration was significantly higher in male rats treated with 1mg/kg BPA compared to control. Iron muscle concentration was significantly increased in male and female rats treated with 1mg/kg BPA compared to control. Muscle calcium concentration was significantly decreased in male rats treated with 1mg/kg BPA compared to control.
650			_aDepartment of Physiology _94504
700			_adr. Muhammad Shahbaz Yousaf _94996
700			_aDr. Saif ur Rehman Kashif _914671
942			_cTH
999			_c8801 _d8800