000			03688nam a22002297a 4500
005			20160815113033.0
008			160815b2016 xxu||||| |||| 00| 0 eng d
041			_aeng
082			_a2499-T
100			_aMuhammad Fahimullah Khan (2009-VA-137) _925456
110			_cProf. Dr. Aneela Zameer Durrani _98839
245			_aComparative Potency Of Two Different Trivalent Vaccines Against Foot And Mouth Disease In Cattle Around The Area Of Ravi Campus Pattoki
260			_c2016.
300			_a66p.;
502			_aFoot and Mouth Disease is a highly contagious viral disease of all cloven footed animals. The best control strategy of this disease is effective and in time vaccination. A successful vaccination campaign depends on the serotype identification and specific vaccination against the prevalent serotype of the virus. The present study was designed to evaluate comparative potency of two anti-FMDV vaccines (UVAS-FMD, Deccivac Intervet) used in cattle around areas of Lahore Pakistan. Blood samples were taken from vaccinated animals on day 0, 30, 60 and 90 post priming. Antibody titer was evaluated with different route of administration and various adjuvant based vaccines. Four animal groups were made each containing 5 animals; in group 1 UVAS vaccine was used by Sub/ Cut route (gel based) at priming dose, followed by Intra Muscular (oil) on 30th day. In group 2 UVAS vaccine was given I/M (oil) as priming dose and booster (oil) I/M. In group 3 Deccivac (oil) vaccine was used I/M for priming and boosting. In group 4 Deccivac (oil) vaccine was used as Sub/ Cut for priming and boosting. The results revealed non-significant difference (p>0.05) among the four different groups administered with FMDV vaccines when evaluated at day 30 and significant difference (p<0.05) at day 60 and 90 post vaccination. Analysis of variance showed significant difference (p<0.05) in antibodies between groups and with in groups at day 60 and 90. Gel based vaccine gave quick antibody response which later maintained with oil based booster dose. The difference in antibody titers obtained in the present study was found non-significant (P>0.05) between the antibody titers of FMD trivalent vaccine of UVAS and Deccivac at 90th day of inoculation. There was significant difference (p<0.05) between the adjuvants of vaccine. Animals inoculated with priming dose of gel based vaccine followed by oil based boosting showed significantly high anti FMD antibody titer than animals inoculated with oil for both priming and boosting. There was significant Summary 54 difference (p<0.05) between the groups vaccinated with various routes of administration. The animals inoculated with priming dose through s/c followed by boosting dose i/m showed significantly high anti FMD antibody titer at 90th day of inoculation compared with those inoculated intramuscularly for both priming and boosting. The animals inoculated with oil based vaccine for both priming and boosting through S/c showed marked significant decreased in anti FMD antibody titer. The route of administration revealed significant difference (p<0.05) in antibody response within groups and between groups at day 30, 60 and 90. In all three readings the mean for sub/cut priming and IM boosting were found significantly high (p<0.05) as compared to other routes. In conclusion it is recommend from the study that FMD vaccination with sub/cut priming and booster dose with IM route.
650			_aDepartment of Clinical Medicine _925457
650			_aCMS _925458
650			_aClinical Medicine _925459
700			_aDr. Muhammad Ijaz _96093
700			_aDr. Jawad Nazir _94972
942			_cTH
999			_c8978 _d8977