Aiysha Ejaz

Study Of Hepatic Dysfunction In Patients Infected With Dengue Virus - 2010

Dengue is the mosquito born viral illness which causes a broad spectrum of disease ranging from in apparent infection, flu like mild undifferentiated fever and classical DF to the most severe form DHF and DSS in which rate of morbidity and mortality is very high. Dengue infection also causes liver damage and this liver impairment is more marked in case of DHF. My study was also aimed at depicting the fact that dengue infection also causes hepatic impairment which is directly the level of dengue 1gM in the body. The serum liver enzyme level rises as the infection progress.

I conducted my study over 200 patients of different age groups including both sexes. All of the patients were having history of pyrexia of unknown origin for the last 7-lO days not subsiding inspite of taking treatment. Some of them presented with mild to moderate petechiae rashes on their body. I categorized the patients into two categorize according to the WHO criteria that is the patients having high grade fever with rash and thrombocytopenia were designated as dengue hemorrhagic fever while those without rash and hemorrhagic manifestations were said to be dengue fever group. Firstly I screened all patients for anti dengue 1gM by rapid strip testing method which shows dark pink line in addition to control line in positive cases within few minutes. The strip +ve cases were further confirmed by using capture ELISA, The Dengue 1gM Capture ELISA (MACELISA) is the immunoenzymatic system recommended by the Pan American Health Organization and the World Health Organization for the serological diagnosis of dengue virus infection due to its high sensitivity, ease of performance, and use of a single acute- phase serum sample. Then all the ELISA +ve cases were estimated for hepatic dysfunction by performing their liver function test. For performing liver function test the serum was obtained by centrifuge machine and enzyme including AST, ALT and Alkaline phosphatase were done by using Merck biochemistry Analyzer which calculated the enzyme itself and displayed the reading in U/L. The analysis established that DF is more common in 21-30 years of age group, more prevalent in males and the level of serum liver enzyme rises as the serum level of dengue 1gM raises that is with the increase of severity of infection.

Department of Pathology


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