Study Of Hepatic Dysfunction In Patients Infected With Dengue Virus (Record no. 2917)

000 -LEADER
fixed length control field 02849nam a2200193Ia 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20151001145108.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s2010 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 1199,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Aiysha Ejaz
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Prof. Dr. Younus Rana
245 ## - TITLE STATEMENT
Title Study Of Hepatic Dysfunction In Patients Infected With Dengue Virus
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 2010
502 ## - DISSERTATION NOTE
Dissertation note Dengue is the mosquito born viral illness which causes a broad spectrum of disease ranging from in apparent infection, flu like mild undifferentiated fever and classical DF to the most severe form DHF and DSS in which rate of morbidity and mortality is very high. Dengue infection also causes liver damage and this liver impairment is more marked in case of DHF. My study was also aimed at depicting the fact that dengue infection also causes hepatic impairment which is directly related.to the level of dengue 1gM in the body. The serum liver enzyme level rises as the infection progress.

I conducted my study over 200 patients of different age groups including both sexes. All of the patients were having history of pyrexia of unknown origin for the last 7-lO days not subsiding inspite of taking treatment. Some of them presented with mild to moderate petechiae rashes on their body. I categorized the patients into two categorize according to the WHO criteria that is the patients having high grade fever with rash and thrombocytopenia were designated as dengue hemorrhagic fever while those without rash and hemorrhagic manifestations were said to be dengue fever group. Firstly I screened all patients for anti dengue 1gM by rapid strip testing method which shows dark pink line in addition to control line in positive cases within few minutes. The strip +ve cases were further confirmed by using capture ELISA, The Dengue 1gM Capture ELISA (MACELISA) is the immunoenzymatic system recommended by the Pan American Health Organization and the World Health Organization for the serological diagnosis of dengue virus infection due to its high sensitivity, ease of performance, and use of a single acute- phase serum sample. Then all the ELISA +ve cases were estimated for hepatic dysfunction by performing their liver function test. For performing liver function test the serum was obtained by centrifuge machine and enzyme including AST, ALT and Alkaline phosphatase were done by using Merck biochemistry Analyzer which calculated the enzyme itself and displayed the reading in U/L. The analysis established that DF is more common in 21-30 years of age group, more prevalent in males and the level of serum liver enzyme rises as the serum level of dengue 1gM raises that is with the increase of severity of infection.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Pathology
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr. Muti ur Rehman
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Prof. Dr. Azhar
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-28 1199,T 1199,T Thesis


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