Farah Abid

Comparative Pharmacokinetics Of Silymarin In Healthy Male And Female Volunteers - 2011

The study was designed to compare the pharmacokinetic parameters of Silymarin in 8
healthy male and 8 healthy female volunteers. Only those healthy volunteers were
selected who were of age between 18-45 years, not having any disease. Female's
volunteers were also of age of 18-45 years and also who were not pregnant and also not
suffering from any disease.

Written consent form were taken from the volunteer and they were thoroughly
inform about the study and objectives of study ,frequency of blood sampling, and any
other side effects linked to the drug which they might having during the study.

Volunteers were divided into two groups A and B respectively. Both groups
were given silymarin 200mg dose per oral to each individua1.5ml of blood samples were
drawn after different time interval .5 ,1,2,3,5,8 and 12 hr from the vein through 5ml BD
syringes of 22 gauge needle after oral administration of silymarin.

Plasma were separated by centrifugation at 5000 RPM and stored at -40 C till
analysis. Silymarin concentration in plasma was determined by using HPLC method. All
pharmacokinetics parameter were determined by entering the plasma concentration time
data in software APO pharmacological analysis .Then pharmacological parameters in
healthy male and healthy females were compared. Result showed that pharmacokinetic
parameters are significant & those parameters were AVC, Tmax, t1l2 & CI. This result
showed that there is a significant relationship between healthy male & female.

Department of Pharmaoclogy & Toxicology


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