Comparative Pharmacokinetics Of Silymarin In Healthy Male And Female Volunteers (Record no. 3045)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02061nam a2200193Ia 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20151005140951.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150525s2011 xx 000 0 und d |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 1329,T |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Farah Abid |
| 110 ## - MAIN ENTRY--CORPORATE NAME | |
| Location of meeting | Prof.Dr.Muhammad Ashraf |
| 245 ## - TITLE STATEMENT | |
| Title | Comparative Pharmacokinetics Of Silymarin In Healthy Male And Female Volunteers |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Year of publication | 2011 |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | The study was designed to compare the pharmacokinetic parameters of Silymarin in 8 healthy male and 8 healthy female volunteers. Only those healthy volunteers were selected who were of age between 18-45 years, not having any disease. Female's volunteers were also of age of 18-45 years and also who were not pregnant and also not suffering from any disease. Written consent form were taken from the volunteer and they were thoroughly inform about the study and objectives of study ,frequency of blood sampling, and any other side effects linked to the drug which they might having during the study. Volunteers were divided into two groups A and B respectively. Both groups were given silymarin 200mg dose per oral to each individua1.5ml of blood samples were drawn after different time interval .5 ,1,2,3,5,8 and 12 hr from the vein through 5ml BD syringes of 22 gauge needle after oral administration of silymarin. Plasma were separated by centrifugation at 5000 RPM and stored at -40 C till analysis. Silymarin concentration in plasma was determined by using HPLC method. All pharmacokinetics parameter were determined by entering the plasma concentration time data in software APO pharmacological analysis .Then pharmacological parameters in healthy male and healthy females were compared. Result showed that pharmacokinetic parameters are significant & those parameters were AVC, Tmax, t1l2 & CI. This result showed that there is a significant relationship between healthy male & female. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Department of Pharmaoclogy & Toxicology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Mateen |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dr. Sualeha Riffat |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Damaged status | Collection code | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Veterinary Science | UVAS Library | UVAS Library | Thesis Section | 2015-05-29 | 1329,T | 1329,T | Thesis |