Comparative Immunogenic Evaluation Of Live Sheep Pox Vaccines Prepared In Vitro And In Vivo (Record no. 1969)

000 -LEADER
fixed length control field 02183nam a2200205Ia 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20150915135717.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150525s1977 xx 000 0 und d
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 0201,T
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Anwar Mahmood, M
110 ## - MAIN ENTRY--CORPORATE NAME
Location of meeting Ata Ur Rehman Rizvi
245 ## - TITLE STATEMENT
Title Comparative Immunogenic Evaluation Of Live Sheep Pox Vaccines Prepared In Vitro And In Vivo
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Year of publication 1977
502 ## - DISSERTATION NOTE
Dissertation note Romanian sheep pox virus was pronagate1 in milk teeth susceptible sheep using Borrel techniqne.

The vaccine has a titre of 10-5 in sheep.

A dose of 0.1 ml. of dilution 1:20 was recommended for each sheep. Vaccinated sheep showed a medium size (1 ½ cm- 2 cm) skin reaction at the site of inoculation and mold fever which remained for two days.

Non of the vaccinated sheep showed any secondary lesions or ill effects.

Confluent primary monolayer of testis cells was achieved after 48 hours, CPE started 96 hours post-infection, and 80 percent CF! was noticed on 7th post-infection day.

Vaccine had titre upto 10-4.5 in vitro which correlates The titre in vivo.

0.5 Tissue culture vaccine Containing 100 TCID50 was injected sub/cut to each sheep. It conferred solid immunity.

Both the vaccines withstood challenge infection with a dose of 1 ml (10,000RD) for animal given on 14th post vaccination day.

0.5 ml dose of 1:25 dilution of Romanian virus vaccine gave larger skin reaction which lead to necrosis. Therefore, 0.1 ml dose of 1:20 dilution was used in the study.

5 ml (1.00 TCID 50) of Tissue vaccine when given to sheep did not show any untoward reactions.

Both vaccines gave cross protection against local sheep pox virus and are antigenically related.

Both vaccines showed cross immunity with each other.

The propagation of sheep pox virus in tissue culture is most economical and reliable method.

Tissue culture sheep pox virus vaccine is easy to administer and is recommended for a mass vaccination/sheep pox control programme.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Microbiology
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Muhammed Yousaf Vaid
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Sheikh Altaf
710 ## - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element Faculty of Veterinary Sciences
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
Holdings
Damaged status Collection code Permanent Location Current Location Shelving location Date acquired Full call number Accession Number Koha item type
  Veterinary Science UVAS Library UVAS Library Thesis Section 2015-05-26 0201,T 0201,T Thesis


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