Pharmacokinetics Of Meloxicam In Different Species
By: Khawaja Tahir Mahmood (2003-VA-207)
| Prof.Dr.Muhammad Ashraf.
Contributor(s): Dr. Mansoor Ud Din Ahmad | Dr. Makhdoom Abdul Jabbar.
Material type: 
BookPublisher: 2009Subject(s): Department of Pharmaoclogy & Toxicology | Phd. thesisDDC classification: 1073,T Dissertation note: Meloxicam is a non-steroidal anti inflammatory drug. It has been registered in Pakistan as a safe substitute of diclofenac sodium which was banned for veterinary use due to its relay toxicity associated with the catastrophic decline in vulture population of the subcontinent.
Marked inter-species differences in the pharmacokinetics of NSAIDs have been reported and pharmacokinetic data cannot be extrapolated from one to another species.
The project was designed to study the pharmacokinetic parameters of meloxicam in domestic animals under local conditions. The study was completed in two phases. A simple, precise and accurate HPLC analytical methods for measurement of meloxicam in biological fluids was standardized and validated in phase-I. The pharmacokinetic parameters and absolute bioavailability of meloxicam in dogs were investigated in phase-I whereas pharmacokinetic parameters of meloxicam were characterized in the horses, donkeys, buffalo, and goats in phase-Il.
Eight healthy animals of each species (dogs, horses, donkeys, buffalos and goats) were used for this project. The dose for these animals was chosen from literature in order to achieve plasma concentrations of meloxicam that were likely to have an effect against inflammation.
The samples of blood were drawn as per protocol before and after medication at various time intervals. The separated plasma was stored at -20 °C till analyzed.
| Item type | Current location | Collection | Call number | Status | Date due | Barcode | Item holds |
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 1073,T (Browse shelf) | Available | 1073,T |
Meloxicam is a non-steroidal anti inflammatory drug. It has been registered in Pakistan as a safe substitute of diclofenac sodium which was banned for veterinary use due to its relay toxicity associated with the catastrophic decline in vulture population of the subcontinent.
Marked inter-species differences in the pharmacokinetics of NSAIDs have been reported and pharmacokinetic data cannot be extrapolated from one to another species.
The project was designed to study the pharmacokinetic parameters of meloxicam in domestic animals under local conditions. The study was completed in two phases. A simple, precise and accurate HPLC analytical methods for measurement of meloxicam in biological fluids was standardized and validated in phase-I. The pharmacokinetic parameters and absolute bioavailability of meloxicam in dogs were investigated in phase-I whereas pharmacokinetic parameters of meloxicam were characterized in the horses, donkeys, buffalo, and goats in phase-Il.
Eight healthy animals of each species (dogs, horses, donkeys, buffalos and goats) were used for this project. The dose for these animals was chosen from literature in order to achieve plasma concentrations of meloxicam that were likely to have an effect against inflammation.
The samples of blood were drawn as per protocol before and after medication at various time intervals. The separated plasma was stored at -20 °C till analyzed.
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