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Chemotheraph Of Ancylostomiasis In Cats In Lahore.

By: Awais Bokhari | Prof. Dr. Muhammad Sarwar Khan.
Contributor(s): Dr. Muhammad Hassan Saleem | Dr. Nisar.
Material type: materialTypeLabelBookPublisher: 2012Subject(s): Department of Clinical Medicine & SurgeryDDC classification: 1391,T Dissertation note: It has been a long time since the affection of cats is with human beings. Cats have recorded as most adoptable pet of the modern world. Cats can be found anywhere in the world. Many diseases of cats are zoonotically important and they may cause zoonotic problem in human and mainly these pathogen are involved in enteric problems. The relationship of feline with human does provide many benefits to them but also act as a cause of zoonotic diseases. A total of 300 fecal samples were collected from cats and were examined in the Clinical Medicine Laboratory, University of Veterinary and Animal Sciences, Lahore. The positive samples for Ancylostoma were 65 out of 300, indicating prevalence of Ancylostomiasis was 21.66%. For the chemotherapeutical trails 18 positive cats and 6 healthy cats were divided into four groups viz. A, B, C and D with 6 animals in each group. The cats of group A were treated with Pyrantel Pamoate @ 20mg/kg orally. The cats of Group B were treated with the Albendazole @ 50mg/kg orally. The cats of Group C were kept as positive control while the cats of Group D were kept as negative control. The fecal samples were collected on day 0 pre-treatment and then on day 7th, 14th and 21st of post-treatment. The efficacy of the drugs was calculated on the basis of reduction of the eggs count from the fecal samples on the respective days. The efficacy of Pyrantel Pamoate on these days was 43.47%, 67.39% and 94.20% respectively, against Ancylostoma. The efficacy of Albendazole on these days was 30.77%, 60.44% and 86.81% respectively, against Ancylostoma. Thus it was recorded that Pyrantel Pamoate was more effective against Ancylostoma than Albendazole as it caused more reduction of the egg count than albendazole. Hematological study showed that the values of hemoglobin, packed cell volume and total erythrocyte count were lower in groups A, B and C as compared to non-infected control group. The values of total leukocyte count were higher in group A, B and C as compared to non-infected group. As a result of treatment in group A and B, the values of hemoglobin, packed cell volume and total erythrocyte gradually increased while that of total leukocyte count gradually decrease on day 7th, 14th and 21st post-medication. It has been observed during the present study that Pyrantel Pamoate and Albendazole showed their positive effect on blood parameters as a result of Ancylostomiasis with more efficacy of Pyrantel pamoate as compared to that of Albendazole.
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Thesis Thesis UVAS Library
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Veterinary Science 1391,T (Browse shelf) Available 1391,T
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It has been a long time since the affection of cats is with human beings. Cats have recorded as most adoptable pet of the modern world. Cats can be found anywhere in the world. Many diseases of cats are zoonotically important and they may cause zoonotic problem in human and mainly these pathogen are involved in enteric problems. The relationship of feline with human does provide many benefits to them but also act as a cause of zoonotic diseases.
A total of 300 fecal samples were collected from cats and were examined in the Clinical Medicine Laboratory, University of Veterinary and Animal Sciences, Lahore. The positive samples for Ancylostoma were 65 out of 300, indicating prevalence of Ancylostomiasis was 21.66%. For the chemotherapeutical trails 18 positive cats and 6 healthy cats were divided into four groups viz. A, B, C and D with 6 animals in each group. The cats of group A were treated with Pyrantel Pamoate @ 20mg/kg orally. The cats of Group B were treated with the Albendazole @ 50mg/kg orally. The cats of Group C were kept as positive control while the cats of Group D were kept as negative control.
The fecal samples were collected on day 0 pre-treatment and then on day 7th, 14th and 21st of post-treatment. The efficacy of the drugs was calculated on the basis of reduction of the eggs count from the fecal samples on the respective days. The efficacy of Pyrantel Pamoate on these days was 43.47%, 67.39% and 94.20% respectively, against Ancylostoma. The efficacy of Albendazole on these days was 30.77%, 60.44% and 86.81% respectively, against Ancylostoma. Thus it was recorded
that Pyrantel Pamoate was more effective against Ancylostoma than Albendazole as it caused more reduction of the egg count than albendazole.
Hematological study showed that the values of hemoglobin, packed cell volume and total erythrocyte count were lower in groups A, B and C as compared to non-infected control group. The values of total leukocyte count were higher in group A, B and C as compared to non-infected group. As a result of treatment in group A and B, the values of hemoglobin, packed cell volume and total erythrocyte gradually increased while that of total leukocyte count gradually decrease on day 7th, 14th and 21st post-medication. It has been observed during the present study that Pyrantel Pamoate and Albendazole showed their positive effect on blood parameters as a result of Ancylostomiasis with more efficacy of Pyrantel pamoate as compared to that of Albendazole.

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