Keeping in view the importance of sheep in global agricultural economy valued by humans for its multiple uses. The present study was conducted on cryptosporidiosis, and to evaluate the comparative efficacy of paromomycin and Kalvanji therapy in lambs in and around Lahore Pakistan. In this plan of research work 400 lambs, less than 1 month of age suspected for cryptosporidium infection on the basis of clinical signs were included. The fecal sample were collected from sheep presented at medicine outdoor hospital of University of Veterinary and animal sciences, various veterinary hospitals in and around Lahore and was processed in medicine laboratory UVAS ,Lahore for observing the oocyst of cryptosporidium by using Ziehl-neelsen technique. The prevalence was found to be 24.25%., The 40 sheep were divided into four groups=designated as A, B, C & D. Each group was comprised of 10 sheep. In group A the infected sheep was treated with paromomycin@ 100 mg/kg orally for 5 days, Group B infected sheep was treated with Kalvanji@1/2 tea spoon for 5 days. Group C infected sheep kept for positive control, whereas healthy sheep group D were kept in negative control. After the 5 days treatment The effect of drugs were checked, by reduction of oocyst, at 0, 7 and 14 day. Oocysts of cryptosporidium were counted by using Mc Master Technique. The therapeutic results of this study concluded that paromomycin was much effective for cryptosporidiosis. we also done hematological studies on 40 sheep(n=30 sheep with cryptosporidiosis and n=10 healthy sheep) was included to see the effect of drugs on various blood parameters i.e PCV,TLC, The 5 ml blood were collected from each lamb directly from jugular vein, and were shifted into a sterilized plastic bottle coated with EDTA@1mg/ml were further analyzed through hematological analyzer . In disease condition the TLC and PCV was increased. The results showed the decrease number of TLC and PCV. One way ANOVA was used to analyze the data.
The outcome of this study would helped to control cryptosporidiosis in lambs and reduce their substantial losses rendered by cryptosporidium. It was concluded that paromomycin is much effective drug against cryptosporidiosis, as compared to Kalvanji oil.